- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05760950
A Cohort Study of Patients With Intracranial Hemorrhage
China Cohort of Patients With Intracranial Hemorrhage
As one of the most serious forms of acute stroke, the early mortality rate of intracerebral hemorrhage(ICH) can be as high as 30-40%. The incidence of intracerebral hemorrhage increases with the increase of age. Under the circumstance of the aggravation of aging in China, intracerebral hemorrhage brings a certain burden to families and society.
The results of several studies in recent years have failed to provide new therapeutic approaches for the treatment of cerebral hemorrhage. Therefore, novel therapeutic approaches is urgently needed for ICH. Primary and secondary prevention, acute inpatient care, and poststroke rehabilitation are all critical. The objective of this cohort study is to explore factors that might influence the long-term prognosis of patients with ICH and to further identify new potential targets for intervention.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Xunming Ji
- Phone Number: 010-83199430
- Email: jixm@ccmu.edu.cn
Study Contact Backup
- Name: Mengke Zhang
- Email: zwzmk985@126.com
Study Locations
-
-
Beijing
-
Beijing, Beijing, China, 100069
- Recruiting
- Xuan Wu Hospital,Capital Medical University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Primary intracerebral hemorrhage
- Over 18 year-old
Exclusion Criteria:
- Secondary intracerebral hemorrhage, such as aneurysmal, hemorrhagic transformation of ischemic stroke, cavernomas, arterio-venous malformations, central venous thrombosis, trauma-related, or tumor.
- Pregnant patients.
- Any condition which, in the judgment of the investigator, might increase the risk to the patient.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Functional outcome
Time Frame: 90-day
|
evaluated by modified Rankin Scale
|
90-day
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Neurological deterioration
Time Frame: 14-day
|
evaluated by NIHSS or GCS
|
14-day
|
Functional outcome
Time Frame: 1-year
|
evaluated by modified Rankin Scale
|
1-year
|
Cerebrovascular disease event
Time Frame: 2-year
|
ischemic and hemorrhagic events
|
2-year
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Xunming Ji, Study Principal Investigator Xuanwu Hospital, Beijing
Publications and helpful links
General Publications
- Jolink WM, Klijn CJ, Brouwers PJ, Kappelle LJ, Vaartjes I. Time trends in incidence, case fatality, and mortality of intracerebral hemorrhage. Neurology. 2015 Oct 13;85(15):1318-24. doi: 10.1212/WNL.0000000000002015. Epub 2015 Sep 16.
- Greenberg SM, Ziai WC, Cordonnier C, Dowlatshahi D, Francis B, Goldstein JN, Hemphill JC 3rd, Johnson R, Keigher KM, Mack WJ, Mocco J, Newton EJ, Ruff IM, Sansing LH, Schulman S, Selim MH, Sheth KN, Sprigg N, Sunnerhagen KS; American Heart Association/American Stroke Association. 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2022 Jul;53(7):e282-e361. doi: 10.1161/STR.0000000000000407. Epub 2022 May 17. No abstract available.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Cohort Study for ICH
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Intracerebral Hemorrhage
-
Wake Forest University Health SciencesActive, not recruitingStroke Hemorrhagic | Intracerebral Hemorrhage | Cerebral Edema | Intracerebral Hemorrhage, Hypertensive | Intracerebral Hemorrhage IntraparenchymalUnited States
-
Beijing Tiantan HospitalBeijing Friendship Hospital; RenJi Hospital; Qilu Hospital of Shandong University and other collaboratorsRecruitingSpontaneous Intracerebral HemorrhageChina
-
University Hospital, Basel, SwitzerlandSwiss Heart FoundationActive, not recruitingIntracerebral Hemorrhage (ICH)Switzerland
-
University of Erlangen-Nürnberg Medical SchoolCompleted
-
AegisCN LLCCompletedIntracerebral Hemorrhage (ICH)United States
-
Tongji HospitalUnknown
-
Huazhong University of Science and TechnologyUnknownHypertensive Intracerebral HemorrhageChina
-
Huazhong University of Science and TechnologyUnknownHypertensive Intracerebral HemorrhageChina
-
CellMed AG, a subsidiary of BTG plc.TerminatedIntracerebral Hemorrhage (ICH)Germany
-
Tang-Du HospitalRecruitingIntracerebral Hemorrhage;Circulating ExosomesChina
Clinical Trials on Routine clinical treatment
-
Capital Medical UniversityRecruiting
-
Shanghai Mental Health CenterCompleted
-
Xuanwu Hospital, BeijingBeijing Tiantan Hospital; West China Hospital; Second Affiliated Hospital of... and other collaboratorsRecruiting
-
Shanghai Mental Health CenterNational Natural Science Foundation of China; Ministry of Science and Technology... and other collaboratorsUnknownClinical High-riskChina
-
University of LeicesterUniversity Hospitals, LeicesterNot yet recruitingAchilles Tendon Rupture
-
Southern Medical University, ChinaRecruiting
-
Hoffmann-La RocheCompleted
-
Ferring PharmaceuticalsCompleted
-
University of AberdeenQueen's University, BelfastCompleted
-
University of LeicesterUniversity Hospitals, LeicesterRecruitingAchilles Tendon RuptureUnited Kingdom