Delayed Dinner, Exercise and Glucose Metabolism

April 4, 2023 updated by: Yung-Chih Chen, National Taiwan Normal University

Impact of Exercise on Metabolic Health Following Delayed Dinner Consumption in Healthy Adults

This study aims to investigate whether exercise can alleviate the impact of delayed dinner on metabolic health next morning in sedentary healthy adults

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Physical inactive males
  • Weight stable for more than 3 months (no change in weight +/- 3%)
  • Non-smoker
  • Able to walk comfortably on a treadmill
  • Dinner consumers with normal sleep pattern (cycles)

Exclusion Criteria:

  • Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
  • Taking medications that may influence lipid or carbohydrate metabolism or immune system function
  • Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Normal dinner consumption
Participants will have their dinner between 1800-1830pm
Behavioral: Normal dinner
Participants will consume breakfast at 0830-0855 am, lunch at 1230-1255 pm, followed by dinner at 1800-1825 pm. Snacks will be consumed at 2130-2140 pm.
Experimental: Delayed dinner consumption
Participants will have their dinner between 2200-2230pm
Behavioral: Delayed dinner consumption
Participants will consume breakfast at 08:30-08:55 am, lunch at 12:30-12:55 pm, followed by snacks at 18:00-18:10 pm. Dinner will be consumed at 21:30-21:55 pm.
Experimental: Exercise with delayed dinner consumption
Participants will exercise on a treadmill for 45 min followed by delayed dinner between 2200-2230pm
Behavioral: Exercise with delayed dinner consumption
Participants will consume breakfast at 08:30-08:55 am, lunch at 12:30-12:55 pm, followed by snacks at 18:00-18:10 pm. Participants will exercise for 45 min at moderate-intensity 45 min prior to the delayed dinner at 21:30-21:55 pm.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Metabolic health (Oral glucose tolerance test, OGTT)
Time Frame: 120 minutes
Fasting and postprandial blood glucose responses on next morning between trials
120 minutes
Metabolic health (Oral glucose tolerance test, OGTT)
Time Frame: 120 minutes
Fasting and postprandial blood insulin responses on next morning between trials
120 minutes

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Inflammation
Time Frame: Baseline
Fasting inflammatory biomarkers (IL-6, TNF-a, CRP) on next morning between trials
Baseline
Visual analogue scale (VSA)
Time Frame: 120 minutes
Changes in VAS from 0-100 mm (e.g., appetite & mood, etc.) on next morning between trials
120 minutes
Substate oxidation
Time Frame: 120 minutes
Lipid and carbohydrate oxidation during OGTT between trials
120 minutes
Blood pressure
Time Frame: 120 minutes
Changes in blood pressure (systolic and diastolic blood pressure) on next morning between trials
120 minutes
Appetite (lunch intake)
Time Frame: 30 minutes
Ab libitum energy intake on next morning by the end of trial
30 minutes
HRV
Time Frame: Baseline
Heart rate variability on next morning between trial
Baseline
Gut hormones
Time Frame: 120 minutes
Changes in blood gut hormones responses on next morning (e.g., GLP-1, PYY and GIP) between trials
120 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Taiwan Normal University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 15, 2022

Primary Completion (Anticipated)

August 15, 2023

Study Completion (Anticipated)

August 15, 2023

Study Registration Dates

First Submitted

March 21, 2023

First Submitted That Met QC Criteria

March 21, 2023

First Posted (Actual)

April 3, 2023

Study Record Updates

Last Update Posted (Actual)

April 7, 2023

Last Update Submitted That Met QC Criteria

April 4, 2023

Last Verified

April 1, 2023

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 202203HM008

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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