Salivary Minerals in Patients With Peri-implantitis (mineral-perio)

June 1, 2023 updated by: Ivana Sutej, University of Zagreb

Analysis of Salivary Minerals Level Variations in Patients With Peri-implantitis

Patients included in the study will be recruited after arriving at the Faculty of Dentistry of the University of Zagreb. During the clinical examination, the patient's periodontal status (bleeding during probing, and the depth of the pockets around the implant) and a control x-ray will be taken to check bone loss. Saliva sampling will occur at 3-time points, when establishing the diagnosis of periimplantitis, before the start of therapy, and at the first control after treatment.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

Work protocol Through the Department of Oral Surgery and the Department of Periodontology, patients with symptoms of peri-implantitis are admitted for a planned intervention or radiological diagnostic-therapeutic procedure within the same day. The number of patients planned for inclusion in this research on changes in the level of salivary minerals in peri-implantitis is 25.

The treatment of peri-implantitis depends on the clinical symptoms, intra- and post-therapeutic complications are not expected, and a control examination is mandatory.

Patient screening Patient selection is based on social and medical criteria. Social criteria - the patient must understand the planned procedure and the postoperative course, agree to the procedure and giving a saliva sample.

Medical criteria - at the time of departure for the planned procedure, the patient's health must be in optimally stable condition if the patient suffers from chronic diseases.

The main clinical parameters are: 1. presence of plaque, 2. presence of BOP, 3. presence of pus, 4. increased probing depth, 5. loss of alveolar bone.

Preparation for the procedure On the day of the examination, the patient comes to the Institute at the agreed time, after which there is a short preparation and, in a pre-established order after a conversation with the researcher, a saliva sample is taken and a dental clinical examination is performed.

Before giving a saliva sample, patients should not eat, smoke or brush their teeth for at least 2 hours before.

Saliva sampling: Just giving a saliva sample is easy. The patient is placed in a quiet place, the method of spontaneous collection of unstimulated saliva is explained to him. Before the very beginning, he rinses his mouth with plain water, and a 5-minute stopwatch is started during which the patient spits the saliva that is produced in his mouth into a previously weighed polystyrene cup. After 5 minutes, the cup with saliva is placed in the freezer until further biochemical analysis, and the patient is referred for a clinical examination. Biochemical analysis: For the salivary minerals determination, a total of 200 μl of unstimulated saliva sample will be mixed with 40 μl of 5% lanthanum oxide and diluted with deionized water to 2.5 ml for atomic absorption spectrophotometry. Due to the strong affinity of calcium to form complexes with salivary proteins, non-centrifuged whole saliva containing both protein-bound and soluble calcium will be used for the assay. The measurements of salivary calcium will be performed by an atomic absorption spectrophotometer.

Clinical examination: the clinical examination will be performed with the help of a graduated periodontal probe. The clinical parameters that will be recorded are:

  • Plaque index
  • Bleeding after probing with a plastic probe (BOP)
  • Supuration, secretion
  • Probing depth greater than 3 mm
  • Bone loss visible on X-ray.
  • Clinical test of stability and mobility.
  • The presence of swelling and redness of the mucous membrane
  • foetor ex ore
  • pain on percussion The treatment of periimplantitis depends on the state of the disease itself. Non-surgical therapy is indicated for peri-implant mucositis, while in the case of further progression of the disease and the appearance of pre-implantitis, non-surgical therapy is only an introduction to treatment, where surgical therapy is the main stage of treatment. For smaller bone defects, the method of choice for treatment is resective surgery, while for larger bone defects, regenerative surgical therapy is indicated.

A control examination is usually scheduled after six weeks. If the bleeding has stopped or decreased and if the probing depths (the depth of the "pockets" around the implant measured with a periodontal probe) have also decreased, the next control is scheduled as needed.

Study Type

Observational

Enrollment (Estimated)

25

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

•Patients who come for examination and treatment of the inflammatory process of a dental implant, peri-implantitis at School of dental medicine University in Zagreb. In order to confirm the diagnosis of peri-implantitis, the clinical criteria are as follows: • bleeding and/or suppuration during light probing; • probing depth of ≥ 3 mm; • loss of bone level ≥ 1 mm apical from the most coronary part of the intraosseous part of the implant.

Description

Inclusion Criteria:

  • diagnosed peri-implantitis

Exclusion Criteria:

  • uncooperative patient
  • younger then 18 years old

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
peri-implant patient
Patients with diagnosed peri-implantitis

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in levels of salivary minerals with disease progression/regression
Time Frame: one year
If it is shown that the minerals of bone metabolism change according to the direction of recovery, it is possible to use salivary minerals (calcium, magnesium and phosphates) as an aid in the prognosis of the course of recovery and reduce the time needed to make a decision on the type and intensity of therapy, as well as the loss itself and implant replacement
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Zagreb

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

October 1, 2023

Primary Completion (Estimated)

October 20, 2025

Study Completion (Estimated)

September 1, 2026

Study Registration Dates

First Submitted

June 1, 2023

First Submitted That Met QC Criteria

June 1, 2023

First Posted (Actual)

June 9, 2023

Study Record Updates

Last Update Posted (Actual)

June 9, 2023

Last Update Submitted That Met QC Criteria

June 1, 2023

Last Verified

June 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1-Mineral-Peri-Imp

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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