Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy Young Individuals

July 12, 2023 updated by: California Baptist University

Effects of Acute Grape Seed Extract Supplementation on Muscle Metaboreflex in Healthy

The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Riverside, California, United States, 92504
        • California Baptist University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Healthy volunteers (SBP < 120 mmHg, DBP < 80 mmHg)

Exclusion Criteria:

  • cardiovascular and/or pulmonary disease,
  • musculoskeletal disorders
  • medications that prevent the safe completion of the exercise protocol

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Randomized double blind grape seed extract design
Grape seed extract
Dietary supplement: Grape seed extract
Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.
Placebo Comparator: Control
Placebo (starch)
Dietary supplement: Grape seed extract
Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Systolic blood pressure (mmHg) by sphygmomanometer
Time Frame: 24 hours
Measured from the brachial artery
24 hours
Diastolic blood pressure (mmHg) by sphygmomanometer
Time Frame: 24 hours
Measured from the brachial artery
24 hours
Mean arterial pressure (mmHg)
Time Frame: 24 hours
calculated (MAP = (SBP-DBP)/3 + DBP
24 hours
Heart rate (bpm)
Time Frame: 24 hours
measured using Physio Flow (non-invasive device)
24 hours
Stroke volume (ml)
Time Frame: 24 hours
measured using Physio Flow (non-invasive device)
24 hours
Cardiac output (l/min)
Time Frame: 24 hours
calculated: HR (bpm) x SV (ml)
24 hours
Total peripheral resistance (mmHg/l/min)
Time Frame: 24 hours
calculated: MAP (mmHg) / CO (l/min)
24 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

California Baptist University

Investigators

  • Principal Investigator: Jong-Kyung Kim, California Baptist University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2022

Primary Completion (Actual)

August 31, 2022

Study Completion (Actual)

August 31, 2022

Study Registration Dates

First Submitted

July 3, 2023

First Submitted That Met QC Criteria

July 12, 2023

First Posted (Actual)

July 14, 2023

Study Record Updates

Last Update Posted (Actual)

July 14, 2023

Last Update Submitted That Met QC Criteria

July 12, 2023

Last Verified

July 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 107-2122-EXP

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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