A Study on the Outcome and Its Influencing Factors in Patients With Borderline Personality Disorder

An Ambispective Cohort Study on the Prognosis and Its Influencing Factors of Borderline Personality Disorder

Borderline personality disorder (BPD) is a difficult chronic mental illness. This diagnosis is common in Western countries. Our researchers want to study the outcome and its influencing factors of BPD for the first time in China. Patients with BPD who had been hospitalized in Wuhan Mental Health Center were selected as the subjects. The researchers retrospectively collected the most recent hospitalization data of these patients, and then prospectively follow up them for 2 years to see how their condition will change. By analyzing all data, researchers hope to know deeply about the development law of this illness, and to provide evidence for releasing these patients' suffering.

Study Overview

• Status: Active, not recruiting
• Conditions: Borderline Personality Disorder

Detailed Description

This study is an ambispective cohort study. The information collected in the retrospective part mainly included demographic data, comorbid psychiatric diagnosis, psychotherapeutive and pharmacotherapeutive data, times of hospitalization and patients' contact information. The above data were derived from electronic medical records. After informed consent, prospective follow-up was initiated primarily by telephone interviews and web-based questionnaires, or by in-person assessments at hospital return visits. Enrolled patients will be followed up at 6-month intervals after the first follow-up to assess psychiatric diagnosis, social function, and quality of life. The researchers are senior psychiatrists, all of whom received training on the use of questionnaires and inter-investigator consistency before the follow-up.

Cox Proportional Hazard Model is used to analyze the influencing factors of remission of BPD, and Generalized Estimating Equation Model is used to analyze the influencing factors of the patients' social function and quality of life.

• Study Type: Observational
• Enrollment (Estimated): 270

Contacts and Locations

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China, 430014
      • Wuhan Mental Health Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Inpatients at the Wuhan Mental Health Center

Description

Inclusion Criteria:

• Diagnosis of BPD based on ICD-10 (F60.3)

Exclusion Criteria:

• Comorbidity with severe physical disease
• Comorbidity with neurological diseases such as epilepsy
• Comorbidity with mental retardation

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
remission rate	The remission rate is calculated as the number of patients who no longer met the diagnostic criteria for BPD for at least 6 months divided by the total number of enrolled patients. The diagnostic tool is ICD-10 (F60.3).	After the first follow-up, patients will be followed up every 6 months, and the total follow-up time was 2 years.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
social disability	Social disability refers to the patient's occupation, family, social life, personal life and other aspects of functional deficits, using Social Disability Screening Schedule (SDSS) to assess.	After the first follow-up, patients will be followed up every 6 months, and the total follow-up time was 2 years.
quality of life	Someone's quality of life is the extent to which their life is comfortable or satisfying. The study used WHOQOL-BREF to assess patients' quality of life in the physical, psychological, social relationship, and environmental domains.	After the first follow-up, patients will be followed up every 6 months, and the total follow-up time was 2 years.

Collaborators and Investigators

• Sponsor: Wuhan Mental Health Centre
• Investigators: Study Director: Fan Yang, Master, Wuhan Mental Health Centre

Study record dates

Study Major Dates

• Study Start (Actual): October 22, 2021
• Primary Completion (Estimated): August 1, 2024
• Study Completion (Estimated): September 1, 2024

Study Registration Dates

• First Submitted: August 15, 2023
• First Submitted That Met QC Criteria: August 15, 2023
• First Posted (Actual): August 22, 2023

Study Record Updates

• Last Update Posted (Actual): August 22, 2023
• Last Update Submitted That Met QC Criteria: August 15, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Personality Disorders; Borderline Personality Disorder
• Other Study ID Numbers: KY2018.77

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No