- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06055582
To Study the Effects of Mango Ingestion in T2DM and Non-diabetic Subjects.
A Randomized Controlled Study to Compare Effects of Mango Ingestion on Glycemia (Glycemic Response, Continuous Glucose Monitoring and Fructosamine) Insulin Resistance and Body Composition in Patients With T2DM and Non-diabetic Subjects.
T2DM patient will be recruited from endocrine OPD
Clinical History and Examination:
General Physical Examination:
- Height (cm)
- weight (kg)
- BMI (kg/m2)
- Blood Pressure (mmHg)
Anthropometry: Circumferences and skinfold thickness will be recorded for the patients in the following manner.
Circumferences:
- Waist circumference (cm)
- Hip circumference (cm)
- Mid-arm circumference (cm)
- Mid-thigh circumference (cm)
Skin fold thickness: Skin fold thickness will be measured by using (LANGE skin fold calipers) (to nearest of 1 mm) at the following sites
- Biceps (mm)
- Triceps (mm)
- Thigh (mm)
- Calf (mm)
- Sub scapular (mm)
- Supra-iliac (mm)
- Anterior axillary fold. (mm)
Biochemical Test: The biochemical analysis will be done using ELISA kit or commercially available kits
- Blood glucose (mg/dL)
- HbA1c (%)
- Serum insulin (μIU/mL)
- Total Cholestrol (mg/dl)
- Triglyceride (mg/dl)
- Fructosamine (umol/L)
- Adiponectin (µg/ml) -- HOMA-IR
- Body Composition Analysis (TANITA)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Phase I: Exploratory Acute Phase- Stratified randomized study
- Study population: 2 groups; patients with T2DM and non-diabetic subjects n=45 (20 T2DM subject, 25 non-diabetic subjects).
- Study groups: 3 groups; OGTT (n=5), mango (n=30), bread (n=10) Subjects in mango group will be further randomized into three different groups. Each group will be tested on a different variety of mango.
Procedure for Phase I:
After measuring baseline glucose level on empty stomach, three groups will be given their respective standardized food item and blood samples will be drawn every half an hour upto 2 hours of ingestion at (minutes): 0, 30, 60, 90 and 120. Fingertip capillary blood will be used for the estimation of blood glucose using a glucometer of contour brand.
Phase II: Exploratory Sub-Acute Phase- Two randomized cross over study
- Study population: 2 groups; patients with T2DM and non-diabetic subjects, n=50 (25 in each study population group)
- Study groups: 2 groups; mango (n=30), bread (n=20) Subjects in mango group will be further randomized into three different groups. Each group will be tested on a different variety of mango.
Procedure for Phase II:
- Continuous glucose monitoring system (CGMS): It will be affixed for 3 days.
- The research team will be contacting the study subjects every day for any discomfort due to CGMS device or diet.
- On day 4 study subjects will be called to the study site and CGMS will be removed and data will be transferred to the study records.
- Study subjects will be asked to maintain a food diary and record the foods consumed during the entire period of 3 days.
- The subjects will also be asked to fill questionnaire of dietary assessment on Day 1 and Day 4 for per schedule of assessments.
Phase III: Confirmatory Chronic Phase- Randomized controlled parallel arm study
- Study population: patients with T2DM, n=35
- Study groups: 2 groups; mango (n=20), bread (n=15) Subjects in mango group will be further randomized into two different groups. Each group will be tested on a different variety of mango.
Procedure for Phase III:
Subjects will be given glucometers and will be asked to monitor blood glucose at fasting state and after standard breakfast meal at baseline, at day 30 and day 60 in both the study groups. The intermediate term effect of mango consumption and bread consumption will be assessed at baseline and at day 60 in terms of following investigations:
- Dietary assessment
- Physical activity (PA) assessment (GPAQ)
- Blood pressure
- Anthropometry measures
- Body composition
- Biochemical investigations
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Delhi
-
New Delhi, Delhi, India, 110048
- Fortis CDOC Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
-For patients with diabetes: Stable glycemic control on metformin or sulfonylurea for past 3 months and without any major complications and HbA1C less than 8%
Exclusion Criteria:
- Acute infections and advanced end-organ damage
- History of hepatitis or pancreatitis, abnormal liver and renal functions
- Recent (<3 months) changes in weight
- Any known allergy to mangoes and bread
- Subjects with hypothyroidism
- On any drug causing weight gain or weight loss.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Treatment - Mango
Subjects in mango group will be further randomized into three different groups.
Each group will be tested on a different variety of mango.
|
250g of mango pulp of each mango variety was given to the subjects.
Other Names:
|
Other: Controlled- Bread
Subjects in bread group were given 81g (3 slices) harvest gold white bread as standard food in raw form.
|
81g (3 slices) harvest gold white bread as standard food.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Outcome for all the phases will be as follows
Time Frame: Baseline, after six months of intervention
|
Fasting glucose (mg/dL)
|
Baseline, after six months of intervention
|
Postprandial blood glucose (mg/dL)
Time Frame: Baseline, after six months of intervention
|
Baseline, after six months of intervention
|
|
Glycemic indices as per Continuous glucose monitoring system (CGMS) & HbA1c (%)
Time Frame: Baseline, after six months of intervention
|
Baseline, after six months of intervention
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Anoop Misra, MD, Fortis CDOC Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 5/9/1309/2020-Nut
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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