Role of MSCT Volumetry in Assessment of Brain Atrophy in Septic Patients

Role of Semi-automatic MSCT Volumetry in Assessment of Rapidly Progressive Brain Atrophy in Septic ICU Patients.

assessment of brain atrophy associated with septic ICU patients by using MSCT Volumetry

Study Overview

• Status: Not yet recruiting
• Conditions: Sepsis-Associated Encephalopathy
• Intervention / Treatment: Device: MSCT

Detailed Description

Sepsis is the leading cause of admission to ICU , the number of patients who survive and discharge from ICU has also increased due to technological advances in ICU however quality of life of these patients after ICU discharge is lower than that of healthy people of a similar age, in particular Sepsis associated encephalopathy associated with brain dysfunction.

We hypothesized that brain damage including brain volume reduction that ocurre in acute phase of Sepsis using CT scan and there finding " relationship to risk factor and outcome".

We compared head CT finding at time of admission with those obtained during the course of the treatment

• Study Type: Observational
• Enrollment (Estimated): 55

Contacts and Locations

• Study Contact: Name: Nada mohamed abdelmoneim; Phone Number: 01097151396; Email: abdelmoneimnada44@gmail.com
• Study Contact Backup: Name: sherif mohamed abdelaal; Phone Number: 01003691110; Email: sherifabdelal@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

All the patients will be included within ehs inclusion criteria after giving informed consent from patients or from the hospital board to review patients' medical records, it will include:

• Full history taking.
• Clinically provisinal diagnosis .
• Blood and bacterial culture was performed at the time of admission for all patients .
• Firstly All studies were performed by using a CT device. CT scans measuring brain volume using BCR which is the width between anterior horn of the bilateral lateral ventricle divided by that of the cerebrum at the same height at the caudate nucleus that measuring in particular frontal lobe volume .
• Also using Evan index which is the width between anterior horn of the bilateral lateral ventricles divided by cranial lumen at the same height .
• When increase BCR and EI ,decrease in brain volume ocurr.

Description

Inclusion Criteria:

• patients >16years old with sepsis associated with disturbance in conscious level admitted to ICU

Exclusion Criteria:

• Age< 16y Brain death Hematological disease Malignant disease Hypoxemia Error in automatic tissue classification Motion artifac

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
cohort; patients >16y with sepsis associated with disturbance in conscious level, the first braun CT scan will be routinely performed on admission, the second further brain CT Scan will be obtained whenever prolonged disturbance of consciousness will be detected.	Device: MSCT; Using Semi-automatic MSCT Volumetry in assessment of brain atrophy associated with septic ICU patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
- Correlation between sepsis and brain volume reduction . - Determine the role of the CT scan in assess brain volume in acute phase of sepsis and it,s influences in improvement activities of daily living.	- Determine the role of the CT scan in assess brain volume in acute phase of sepsis and it,s influences in improvement activities of daily living after discharge from ICU.	follow up through 10 days after admission in ICU

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Principal Investigator: Nada mohamed abdelmoneim, Assiut University; Study Director: sherif mohamed abdelaal, Assiut University; Study Director: samy abdelaziz, Assiut University

Publications and helpful links

General Publications

• Nakae R, Sekine T, Tagami T, Murai Y, Kodani E, Warnock G, Sato H, Morita A, Yokota H, Yokobori S. Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry. Crit Care. 2021 Nov 29;25(1):411. doi: 10.1186/s13054-021-03828-7.

Helpful Links

• retrospective study using semi automatic volumetry

Study record dates

Study Major Dates

• Study Start (Estimated): November 1, 2023
• Primary Completion (Estimated): November 1, 2024
• Study Completion (Estimated): December 30, 2024

Study Registration Dates

• First Submitted: October 27, 2023
• First Submitted That Met QC Criteria: October 27, 2023
• First Posted (Actual): November 1, 2023

Study Record Updates

• Last Update Posted (Actual): November 1, 2023
• Last Update Submitted That Met QC Criteria: October 27, 2023
• Last Verified: October 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Pathological Conditions, Anatomical; Brain Diseases; Atrophy; Sepsis-Associated Encephalopathy
• Other Study ID Numbers: sepsis and brain atrophy

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: Yes