- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06128707
Vestibulo-Ocular Reflex Function in Individuals With Chronic Motion Sensitivity Cross-Sectional Study
Chronic motion sensitivity refers to a sensation of unwellness caused by physical or discerned motion and has a prevalence of 28% in the general population and it is more common in women (27.3%) compared to men.
The investigators theorize that individuals with chronic motion sensitivity will have an impaired inner ear reflex and will be less physically active. Hence, the purpose of this study is to;
- Determine whether the function of an inner ear reflex is different between young adults with/without chronic motion sensitivity
- Assess relationships between reflex function and balance in young adults with/without CMS
- Assess relationships between physical activity and balance in young adults with/without CMS.
Study Overview
Status
Conditions
Detailed Description
Chronic motion sensitivity (CMS), also known as motion sickness, refers to a sensation of unwellness caused by physical or discerned motion. CMS has a prevalence of 28% in the general population and it is more common in women (27.3%) compared to men.
Based on established evidence that individuals with chronic motion sensitivity demonstrate impaired postural stability with vestibular system impairment adjudged to be an inciting stimulus for chronic motion sensitivity, and individuals who practiced more physical and sporting activities have less motion sickness susceptibility than individuals who did not, the investigators theorize that individuals with chronic motion sensitivity will have an impaired inner ear reflex, causing them to be more reliant on other sensory systems like their muscles and joints, and their vision, we also theorize that individuals who are physically active will be less susceptible to chronic motion sensitivity.
The purpose of this study is to;
- Determine whether the function of an inner ear reflex is different between young adults with/without chronic motion sensitivity
- Assess relationships between reflex function and balance in young adults with/without CMS
- Assess relationships between physical activity and balance in young adults with/without CMS.
Participants between the age of 20 and 40 with and without a self-reported history of chronic motion sensitivity (i.e, experiencing nauseousness and/or dizziness during while using various means of transportation such as, car, train, bus, boat, and airplane and/or, recreational fun-fair rides and/or when exposed to conflicting visual images). Participants will be excluded if they report a medical diagnosis of central nervous system disorder, impaired cervical spine range of motion, migraines, seizure disorder, vestibular dysfunction, or any musculoskeletal dysfunction that can limit their participation in the study.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Locations
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California
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Loma Linda, California, United States, 92350
- Recruiting
- Loma Linda University
-
Contact:
- Eric G Johnson, DSc
- Phone Number: 47471 909-558-4632
- Email: ejohnson@llu.edu
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Contact:
- Pabl0 Mleziva, DPT
- Phone Number: 85690 (909) 558-4632
- Email: pmleziva@llu.edu
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Age 20-40
- With and without a history of CMS
Exclusion Criteria:
- CNS disorder
- Impaired cervical spine ROM
- Migraines
- Seizures
- Vestibular dysfunction
- Musculoskeletal dysfunction
- Medications causing dizziness
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Chronic Motion sensitivity group
Participants with a self-reported history of chronic motion sensitivity and who scored greater than or equal to the 30th percentile on the Motion sickness susceptibility questionnaire short form.
|
Non-Chronic Motion sensitivity Group
Participants without a self-reported history of chronic motion sensitivity and who scored less than or equal to the 25th percentile on the Motion sickness susceptibility questionnaire short form.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Bertec vision advantage
Time Frame: 1 day
|
Scores on 4 parametters- Baseline visual acuity (Logarithm of the minimum angle of resolution LogMAR)- A measure of optotype size with lower values signifying smaller optotype size and better vision with the head static, Visual processing time (Mili seconds) this is the time taken to identify the size of the optotype, Dynamic visual acuity (Logarithm of the minimum angle of resolution LogMAR)-A measure of optotype size with lower values signifying smaller optotype size and better vision with the head dynamic, Gaze stability test (Degrees per second), this is the highest speed at which the participant can identify the optotype while the head is moving.
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1 day
|
Computerized dynamic posturography with immersion virtual reality
Time Frame: 1 day
|
Average scores under 2 conditions- Condition one- Eye open, Stable platform, Condition 2 Eye open, sway referenced platform.
Each condition measured gives a score known as the equillibrum score measured as age matched normative data with higher scores signifying stronger balance , and a lower scores signifying weaker balance
|
1 day
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
International Physical activity questionaire short form
Time Frame: 1 day
|
Questionaire to assess physical activity
|
1 day
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Motion sickness susceptibility questionnaire short form
Time Frame: 1 day
|
Questionnaire used to asses motion sickness susceptibility
|
1 day
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB# 5230167
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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