- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06142214
Relationship Between Pan Immune Inflammatory Index and Endometriosis
Pan İmmun İnflamatuar İndeks (PIV) Ile Endometriosiz Arasındaki İlişki
Study Overview
Status
Detailed Description
Endometrosis is a common estrogen-dependent chronic inflammatory disease that causes pelvic pain and infertility. Its etiology is complex and multifactorial and several theories have been proposed to explain its pathogenesis, which are not fully understood. Endometrial cells are characterized by extensive endometrial implants outside the uterus, especially in the ovaries, ligaments and peritoneal surfaces. These implants lead to inflammation resulting in scar tissue banding, also called endometrial adhesions in advanced stages (III and IV). Endometriosis affects 10-15% of reproductive women and is associated with different symptoms such as infertility, chronic pelvic pain, dyspareunia, dysmenorrhea and abnormal uterine bleeding. The American Society for Reproductive Medicine (ASRM) categorizes it into four stages according to the size of endometriotic implants in the ovaries, peritoneum and fallopian tubes and the severity of adhesion.
Stage I: This is also known as minimal endometriosis. In stage I, superficial implants and mild adhesions may grow outside the uterus. The score for minimal endometriosis is between one and five.
Stage II: This is also known as mild endometriosis. With stage II, implants may be superficial or deep with mild adhesions. In stage II, endometriosis may be widespread and deep implants may be present. Score six to 15 for mild endometriosis between Stage III: This is also known as moderate endometriosis. With stage III deep implants are available. Adhesions may also be thin and dense. As a result, endometriosis is more common than in Stage II. The score for moderate endometriosis is between 16 and 40.
Stage IV: This is also known as severe endometriosis. With stage IV, deep implants and dense adhesions are present. There may be superficial endometriosis and thin adhesions, but the disease is more widespread than in Stage III. Any score greater than 40 indicates severe endometriosis.
The pan-immune inflammatory index (neutrophil count X monocyte count X platelet count/lymphocyte count) is a scoring system of immune inflammatory cells in peripheral blood. Although this index was first studied in malignant diseases, it has been found to be associated with non-malignant diseases in subsequent studies.
In the light of the literature, we aimed to determine the relationship between pan immune inflammatory index and endometriosis and endometriosis stages.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Locations
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Yenimahalle
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Ankara, Yenimahalle, Turkey, 06000
- Ankara Etlik City Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Being between the ages of 18-45
- Patients with suspected endometrosis on ultrasonography or MRI or CT
- Patients with a postoperative pathologic diagnosis of endometrioma
- Patients without pelvic pathology operated for bilateral tubal ligation
Exclusion Criteria:
- Diagnosis or evidence of systemic inflammatory disease
- Having an adnexal mass other than endometriosis
- presence of infectious disease
- Mobite obesity
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Endometriosis- Case group
Patients between the ages of 18-45, who applied to the Gynecology outpatient clinic of Etlik City Hospital and were followed up in our hospital, who were suspected of endometriosis on ultrasound or MRI or CT, and who were operated and whose postoperative pathology was compatible with endometriosis will be included in the study.
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Healthy patients-Control
Patients who underwent bilateral tubal ligation in our Gynecology Clinic and who did not have any pelvic pathology will be included as the control group.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Diagnosis of endometriosis -Pan Immune Inflammatory Index
Time Frame: Pre-operative
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neutrophil count x monocyte count x platelet count/lymphocyte count
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Pre-operative
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Stage of endometriosis -Pan Immune Inflammatory Index
Time Frame: Pre-operative
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neutrophil count x monocyte count x platelet count/lymphocyte count
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Pre-operative
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Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AESH-EK1-2023-449
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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Clinical Trials on Relationship Between Pan Immune Inflammatory Index and Endometriosis and Endometriosis Stages
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iSpecimen IncWithdrawnAutoimmune Diseases | Healthy | Cancer | Pregnancy Related | Nephritis | Neuro-Degenerative Disease | Women's Health: Endometriosis | Gastro-Intestinal Disorder | Cardio-Respiratory DistressUnited States
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Jiangsu HengRui Medicine Co., Ltd.CompletedEndometriosis, Uterine Fibroids, Male Hormone-sensitive Prostate Cancer, Assisted ReproductionChina
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Jagiellonian UniversityCompleted
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University of AarhusCompletedIrritable Bowel Syndrome | Endometriosis | Visceral Syndrome | Visceral HypersensitivityDenmark
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University of Texas Southwestern Medical CenterCompletedEndometriosis | Pelvic Pain | Adenomyosis | Metrorrhagia | Pelvic Inflammatory Disease | Leiomyoma | MenorrhagiaUnited States
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novoGIUnknownLymphoma | Colorectal Neoplasms | Endometriosis | Crohn Disease | Colitis, Ulcerative | Intestinal Polyposis | Ileostomy - Stoma | Intestinal Volvulus | Colostomy | Diverticulum, Colon | Rectal ProlapseUnited States