- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06185517
Validation of Questionnaire in Retinal Degeneration (VQDR)
French Translation and Validation of the Michigan Retinal Degeneration Questionnaire and the Michigan Vision-Related Anxiety Questionnaire in a Cohort of People With Hereditary Retinal Degeneration.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Interventional research of category 2 with minimal risks and constraints. This is a prospective, monocentric, longitudinal, non-randomized study to validate the translation of questionnaires to assess abilities in daily living tasks and the potential psychological repercussions of visual impairment in various hereditary retinal dystrophies.
The research will be conducted in two distinct phases:
Comprehension phase and validation phase
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Nabil BROUK
- Phone Number: +331 40 02 11 26
- Email: nbrouk@15-20.fr
Study Contact Backup
- Name: Hayet SERHANE
- Phone Number: +331 40 02 11 44
- Email: hserhane@15-20.fr
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Male or female
- Age: 18 to 80
- Sufficient knowledge of the French language to ensure understanding of the tasks to be performed and the instructions received.
- Signed consent after being informed by the investigator.
- Affiliation with health insurance.
- Affected by one of the following rare pathologies, with different levels of visual field, acuity and contrast sensitivity impairment:
- Non-syndromic rod-cone dystrophy (retinopathy pigmentosa, RP): diagnosis confirmed by a specialist.
- Non-syndromic rod-cone dystrophy: diagnosis confirmed by a specialist.
- Non-syndromic Stargardt's disease: diagnosis confirmed by a specialist.
- Non-syndromic congenital night blindness: diagnosis confirmed by a specialist.
- Non-syndromic achromatopsia: diagnosis confirmed by a specialist.
Exclusion Criteria:
- Pregnancy
- Inability to give informed consent.
- Cataract surgery within 3 months of inclusion.
- Hearing impairment that may interfere with comprehension during the interview.
- Functional amblyopia.
- Inability to comply with instructions to perform study tasks or study visits.
- Drug treatment that may cause motor, visual or cognitive impairment (PSAs, neuroleptics, etc.) or that may interfere with study assessments.
- Other uncontrolled ophthalmic conditions that may interfere with evaluation.
- Participation in another clinical trial that may interfere with the present study.
- Patient under guardianship, curatorship or legal protection
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Comprehension Phase
After an initial translation of the questionnaires into French, the aim of this phase is to ascertain the level of understanding of each questionnaire item and any suggestions, during a telephone or face-to-face interview.
|
Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-Related Anxiety Questionnaire (MVAQ).
Validation of a French translation
|
Experimental: Validation Phase
The aim is to validate the French translation of the Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-Related Anxiety Questionnaire (MVAQ).
|
Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-Related Anxiety Questionnaire (MVAQ).
Validation of a French translation
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Reliability
Time Frame: 2 months
|
will be assessed using intra-class correlations (ICC) between questionnaire measures in test-retest.
|
2 months
|
Acceptability
Time Frame: 2 months
|
will be assessed by analyzing a comprehension questionnaire administered to participants.
|
2 months
|
Internal validity,
Time Frame: 2 months
|
Internal validity is crucial to ensure that the questionnaire questions correctly measure the concept under study.
It is assessed by examining the correlations between similar questions.
High correlations indicate good internal validity, which means that the questionnaire is reliable and accurate for assessing the target concept.
|
2 months
|
Construct validity
Time Frame: 2 months
|
Will be assessed by examining the relationships between questionnaire scores and other theoretically related measures.
High correlations with similar measures and low correlations with unrelated measures indicate good construct validity.
|
2 months
|
Sensitivity
Time Frame: 2 months
|
Will be assessed by analysing the questionnaire's ability to detect significant differences between groups of participants with different levels of disease severity.
A sensitive questionnaire will make it possible to identify subtle differences between groups and will therefore be more useful for assessing the impact of the disease on patients' quality of life.
|
2 months
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Isabelle AUDO, Centre Hospitalier National d'Ophtalmologie
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- P22-07
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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