MIT Intensive Treatment Study (MITTXS)

January 9, 2024 updated by: Andre Lindsey, Nevada State University

Intensive MIT Paired With Video Feedback for Motor Speech Disorders and Aphasia

This study is examining the use of intensive melodic intonation therapy and video feedback as a means of aiding individuals with nonfluent aphasia and co-occurring motor speech impairments. Individuals with nonfluent aphasia have difficulty with language, particularly with word retrieval.

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

1

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Nevada
      • Henderson, Nevada, United States, 89002
        • Nevada State University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Fluent English speakers
  • Sustained a left-hemisphere stroke
  • Presents with language and motor speech impairments

Exclusion Criteria:

  • • History of learning disability prior to accident (per patient report)

    • Uncorrected auditory or visual impairments
    • Not meeting the criteria of stroke
    • Failure to provide evidence of stroke diagnosis (medical record history)
    • History of psychiatric disorder

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Intervention

20 sessions/4 weeks:

Video Feedback:

S1) Participant (P1) views recording of previous session with the clinician & judges whether the production is intelligible.

S2) S1 & the clinician identifies changes in motor movements that are influencing performance.

S3+S4) S1+S2 & given support from the clinician, P1 identifies techniques improving intelligibility & modifies behavior accordingly.

MIT:

Humming - Clinician introduces the target phrase by showing a visual cue, humming the phrase, then intoning (singing) the phrase while P1 taps left-hand.

Unison intoning - Clinician and P1 intone (sing) & tap the target phrase together.

Unison intoning with fading - Clinician & P1 begin to intone (sing) & tap the target phrase together. The clinician fades out, while P1 continues to sing the rest of the phrase accompanied by tapping.

Immediate repetition response to probe question - Following P1's successful repetition, the clinician intones a question and P1 intones the target.
Behavioral: Melodic Intonation Therapy
Melodic Intonation Therapy uses intonation and melody to aid individuals with aphasia with producing words.
Behavioral: Video Feedback Performance Review
Participant will view recording to judge correct and incorrect productions of trained words and to identify motor techniques increasing intelligibility

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Intelligibility
Time Frame: From enrollment to 4 weeks post treatment
Intelligibility as measured by percentage of consonants correct and by targets produced on trained and untrained stimuli. 20 trained and 20 untrained speech phrases that are relevant to the client (measured during reading and repetition tasks)
From enrollment to 4 weeks post treatment

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Apraxia Battery for Adults
Time Frame: Baseline and one week following the end of treatment
A test to measure the presence and severity of apraxia in adults
Baseline and one week following the end of treatment
Assessment of Intelligibility of Dysarthria Speech
Time Frame: Baseline and one week following the end of treatment
A tool for quantifying single-word intelligibility, sentence intelligibility, and speaking rate of adult speakers with dysarthria
Baseline and one week following the end of treatment
Longer Connected Speech Assessment
Time Frame: Baseline and one and four weeks following the end of treatment
Change in Performance on Rainbow Passage- A public domain paragraph frequently used by speech-language pathologists to gather a speech sample of all phonemes for American English
Baseline and one and four weeks following the end of treatment
Quality of Life with Dysarthria (QOLdys)
Time Frame: Baseline and four weeks following treatments.
A reliable and valid tool to assess quality of life for patients with dysarthria.
Baseline and four weeks following treatments.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Nevada State University

Investigators

  • Principal Investigator: Andre Lindsey, PhD, Nevada State University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 28, 2023

Primary Completion (Estimated)

February 1, 2024

Study Completion (Estimated)

June 1, 2024

Study Registration Dates

First Submitted

January 9, 2024

First Submitted That Met QC Criteria

January 9, 2024

First Posted (Actual)

January 19, 2024

Study Record Updates

Last Update Posted (Actual)

January 19, 2024

Last Update Submitted That Met QC Criteria

January 9, 2024

Last Verified

January 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2312-0370

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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