The Interaction Between Resting Metabolic Rate, Physical Activity and Thyroid Hormone in Females

This Study is focused on the interaction between resting metabolic rate (RMR), physical activity (PA), and thyroid hormones (TH). TH controls almost all the cell activities of the body so, it is known as one of the major regulatory hormones. This is the reason for individuals who suffer from thyroid disorders show abnormal metabolism. Recently it was suggested that interindividual variations in thyroid hormone levels also influence daily physical activity.

Study Overview

• Status: Not yet recruiting
• Conditions: Thyroid; Resting Energy Expenditure; Physical Activities

Detailed Description

In this study, investigators will recruit adult females with a BMI ≥18.5. After the screening process, eligible volunteers will undergo certain measurements including body composition, resting metabolism daily physical activity, thyroid hormone levels, and total energy expenditure. The investigators will access the changes in resting metabolism and daily physical activities with the differences in thyroid hormone levels.

• Study Type: Observational
• Enrollment (Estimated): 50

Contacts and Locations

• Study Contact: Name: John R Speakman, PhD; Phone Number: +86 15810868669; Email: j.speakman@abdn.ac.uk
• Study Contact Backup: Name: Sanduni S De Alwis, Bachelor; Phone Number: +86 19065020853; Email: alwis@siat.ac.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

The study participants are adult healthy females.

Description

Inclusion Criteria:

• Female age ≥18;
• BMI≥18.5

Exclusion Criteria:

• Intended weight change exceeding 2kg within the past three months;
• Having any special medical diets or having eating disorders;
• Pregnant women or breastfeeding women;
• People who have metal implants in their bodies;
• Patients with metabolic diseases, infectious diseases, and genetic disorders such as hypothyroidism, and hyperthyroidism;
• Patients with a personal or family history of medullary thyroid carcinoma (MTC), or patients with rare type 2 multiple endocrine tumor syndrome (MEN2); People with a fear of needles (Trypanophobia), claustrophobia; People who are fear of blood (Hemophobia) or pathological hypotension;

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Body weight	Subjects will be asked to fast overnight and weight will be measured using a calibrated Seca body weight scale first thing in the morning on subjects wearing light clothes and no shoes.	Measurements will take at the first day of the visit
Height	Measured by seca 217 stable stadiometer. Subjects wearing no shoes.	Measurements will take at the first day of the visit
Waist and Hip circumferences	Waist and Hip circumferences will be measured using a whole body laser scanner.	Measurements will take at the first day of the visit
Fat mass	Fat mass will be measured by Magnetic Resonance Imaging (Shanghai united imaging, uMR 790 ).	Measurements will take at the first day of the visit
Far free mass	Fat free mass will be measured by Bioimpedance Analysis (Tanita, MC-980).	Measurements will take at the first day of the visit
Bone mass	Bone mass will be measured by DEXA (Hologic).	Measurements will take at the first day of the visit
Resting Metabolism	Resting energy expenditure will be measured using indirect calorimetry via a respiratory hood system (Cosmed). The subject attends the lab after an overnight fast. The person lies down on a flatbed and the hood is placed over their head. Metabolic rates (oxygen consumption and CO2 production) are monitored for 30 minutes. Calorimeters will be assessed with a turbine test to ensure the accuracy of measurements. Validation via an alcohol burn will be performed monthly.	Measurements will take at the first day of the visit.
Physical activity	Physical activity of the participants will be recorded using GT3X accelerometer worn near the hip for a consecutive period of 7 days. The monitor should not be worn while bathing or swimming. The first day is discarded along with any day where the wear time is less than 12 hours. For a valid measure, the goal is to get 2 weekday and 2 weekend days.	Measurements last for 14 days
Thyroid hormone	Nurses will collect the blood samples on day 1. Levels of circulating thyroid hormones will be measured using radio immune assay.	Blood samples will collect at the first day of the visit.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Total energy expenditure	Total energy expenditure (TEE) will be measured using the DLW method. Urine samples from all participants in the DLW subset will be stored at -20 oC and analyzed in the laboratory of Dr. John Speakman at the Shenzhen Institute of Advanced Technology, Chinese Academy of sciences. Isotopes will be measured in a benchtop near-infrared isotope gas analyzer, and mean CO2 production will be calculated from isotope ratios using the recently derived equation (Speakman et al 2021: Cell reports medicine). TEE will then be calculated using mean CO2 production using the Weir equation.	Measurements take for 14 days

Collaborators and Investigators

• Sponsor: Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
• Investigators: Study Chair: John R Speakman, PhD, Shenzhen Institute of Advanced Technology, CAS

Study record dates

Study Major Dates

• Study Start (Estimated): May 1, 2024
• Primary Completion (Estimated): July 31, 2024
• Study Completion (Estimated): October 31, 2024

Study Registration Dates

• First Submitted: April 17, 2024
• First Submitted That Met QC Criteria: April 17, 2024
• First Posted (Actual): April 22, 2024

Study Record Updates

• Last Update Posted (Estimated): May 2, 2024
• Last Update Submitted That Met QC Criteria: April 30, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Endocrine System Diseases; Thyroid Diseases
• Other Study ID Numbers: SIAT-IRB-240415-H0718

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No