Efficacy of i-PRF Usage in Vestibular Socket Therapy

A Novel Method for Evaluating i-PRF Usage in Vestibular Socket Therapy for Immediate Implant in Defective Fresh Extraction Site

This study aims for evaluation of A novel method for evaluating i-PRF usage in vestibular socket therapy for immediate implant in defective fresh extraction site.

Study Overview

• Status: Active, not recruiting
• Conditions: Esthetic Zone
• Intervention / Treatment: Procedure: Immediate implant with VST; Procedure: Immediate implant with VST and i-prf

Detailed Description

The ultimate objective of implant treatment is providing long-lasting, healthy hard and soft tissue architecture while minimizing intraoperative surgical trauma and postoperative complications. Reducing treatment duration and providing a predictable esthetic outcome are fundamental. Immediate implant placement in fresh extraction sockets is an appealing treatment option satisfying many of these requirements. However, a major concern with immediate implant placement is the possible resorption of the facial bone plate as indicated in multiple studies. This, in turn, results in loss of proper soft tissue support, thus compromising the final esthetic outcome of the implant- supported restoration. Furthermore, post extraction bone resorption would be compounded by the presence of a thin or preexisting facial bone defect and/or a thin gingival phenotype. Multiple approaches were suggested to prevent facial bone resorption and optimize the final esthetic outcome after immediate implant placement in sockets with intact facial bone and soft tissue. These approaches include simple ones like applying a graft in the gap between the implant and the facial socket wall and more sophisticated approaches such as the socket shield technique . The presence of bone and/or soft tissue defects after tooth extraction is not an uncommon finding, further complicating immediate implant placement. Several classifications for fresh extraction sockets were proposed to facilitate the selection of optimum treatment for individual cases.

Currently, a serious of studies has shown that iPRF can produce significantly greater concentrations of platelets and leukocytes when compared to the L-PRF and A-PRF.

• Study Type: Interventional
• Enrollment (Actual): 24
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Nasr City
    • Cairo, Nasr City, Egypt, 11371
      • AlAzharU

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Patients has one hopeless tooth in the maxillary anterior region with TYPE II according to Elian classification of sockets (10) and sufficient bone apically and palatally.
• The presence of a natural contralateral tooth for the tooth being replaced.

Exclusion Criteria:

• Extraction sockets were grade III.
• Acute infection related to hopeless tooth.
• Allergy to any material or medication used in the study.
• Medically compromised patients according to modified Cornell Medical Index.
• Heavy smokers.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: deficient facial plate of bone management VST only; Sockets with deficient facial plate of bone and intact soft tissue will receive VST only.	Procedure: Immediate implant with VST; Preoperative procedure: cone beam computed tomography (CBCT) scan will be used for diagnosis and treatment planning. Nonsurgical periodontal treatment including scaling and root planning will be performed as needed. Under local anesthesia sulcular incisions will be made, and then hopeless teeth will be extracted atraumatically using periotomes. Socket lavage and curettage will be done thoroughly, and dental implants will be inserted.
Active Comparator: deficient facial plate of bone management with VST and iPRF.; Sockets with deficient facial plate of bone and intact soft tissue will receive VST and iPRF.	Procedure: Immediate implant with VST and i-prf; Preoperative procedure: cone beam computed tomography (CBCT) scan will be used for diagnosis and treatment planning. Nonsurgical periodontal treatment including scaling and root planning will be performed as needed. Under local anesthesia sulcular incisions will be made, and then hopeless teeth will be extracted atraumatically using periotomes. Socket lavage and curettage will be done thoroughly, and dental implants will be inserted with i-prf.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
assessment of pink aesthetic score of the gingiva	Assessment of clinical and aesthetic parameters after the newly proposed immediate implant placement technique. using pik aesthetic score of gingiva, The Pink Esthetic Score (PES) is a dental assessment tool scoring gingival aesthetics around implants, evaluating mesial/distal papillae, tissue level/contour/color/texture, and alveolar deficiency. Scoring System 0 (Poor): Marked deficiency or abnormality.; (Fair): Slight change or minor discrepancy.; (Excellent): Healthy, normal, ideal appearance.	6 and 9 months.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Facial bone thickness	Assessment of radiographic parameters after the newly proposed immediate implant placement technique.will be assessed from implant surface to outer surface of bone will be recorded using cone beam CT, at base line, 6 and 9 months. and will be recorded in millimeters.	base line, 6 and 9 months.

Collaborators and Investigators

• Sponsor: Al-Azhar University
• Investigators: Principal Investigator: abdullah el-shamy, MSC, Al-Azhar University

Study record dates

Study Major Dates

• Study Start (Actual): November 21, 2023
• Primary Completion (Estimated): January 21, 2026
• Study Completion (Estimated): March 21, 2026

Study Registration Dates

• First Submitted: July 31, 2024
• First Submitted That Met QC Criteria: December 12, 2025
• First Posted (Actual): December 26, 2025

Study Record Updates

• Last Update Posted (Actual): December 26, 2025
• Last Update Submitted That Met QC Criteria: December 12, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: proliferation regulatory factors, human urine
• Other Study ID Numbers: 921/1704

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: Yes