- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00843804
Surveillance for Nosocomial Infections in Pediatric Cancer Patients (Oncoped2006)
25. juni 2010 opdateret af: University Hospital, Bonn
Prospective Surveillance for Nosocomial Infections and Catheter-related Thrombotic Events in Pediatric Patients
The Oncoped 2006 study implements a multicenter prospective surveillance module for nosocomial infections in pediatric cancer patients.
Studieoversigt
Status
Ukendt
Detaljeret beskrivelse
Type of study:
Prospective multicenter surveillance study referring to file data collected routinely during the management of infectious and thrombotic complications in high risk pediatric cancer patients.
Primary aims of the Oncoped 2006 Study
- To describe the epidemiology of selected nosocomial infections in pediatric cancer patients as well on the unit level as in a reference database of cumulative data from a prospective multicenter surveillance perspective.
To allow the participating institution
- to compare its own results with other centers and with the reference database (median and 75. percentile).
- to reduce the incidence density of nosocomial infections and the incidence rate of catheter-associated infections in pediatric cancer patients.
- To promote patient's safety by means of quality assurance and a reduction of nosocomial infections.
- To describe objective outcome variables related to the documented NI events (mortality, duration of hospitalization, need for intensive care, need for surgical interventions)
- To intensify the practical collaboration of the health care team with infection control personnel and infectious disease specialists in this clinical context.
- To describe the distribution of bacterial pathogens of blood stream infections and to determine the sensitivity (minimal inhibitory concentration) of bacterial pathogens detected in blood cultures to first and second line antimicrobial agents in this high risk population with a standardized method (central reference laboratory).
- To detect bacterial isolates with emerging types of antimicrobial resistance.
- To describe the therapeutic use of antibacterial and antifungal agents in pediatric cancer patients related to nosocomial infections.
- To describe the incidence and incidence density of invasive Aspergillosis in pediatric cancer patients.
- To describe the clinical impact of common and emerging viral respiratory pathogens (RSV, Influenza, hMPV, hCoV, hBoV) in pediatric cancer patients with nosocomial lower respiratory tract infection (central reference laboratory for emerging viral pathogens).
- What is the incidence and incidence rate (per 1000 catheter utilization days) of thrombotic events in pediatric cancer patients and in patients with hemophilia, who have a CVAD in use?
- How many of the children with an event do have congenital risk factors (thrombophilia)?
- What are the objective outcome parameters in this population considering antithrombotic treatment (at the discretion of the attending physicians)?
Undersøgelsestype
Observationel
Tilmelding (Forventet)
50
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Arne Simon, MD
- Telefonnummer: 004922828733254
- E-mail: asimon@ukb.uni-bonn.de
Undersøgelse Kontakt Backup
- Navn: Udo Bode, MD
- Telefonnummer: 004922828733310
- E-mail: udo.bode@ukb.uni-bonn.de
Studiesteder
-
-
-
Bern, Schweiz, CH 3010
- Rekruttering
- Children's Hospital, Pediatric Oncology UNit
-
Kontakt:
- Roland Ammann, MD
- Telefonnummer: 0041316329315
- E-mail: rolan.ammann@insel.ch
-
Ledende efterforsker:
- Roland Ammann, MD
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
Ikke ældre end 21 år (Barn, Voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
Pediatric patients with cancer during intensive induction / reinduction treatment (including conventional chemotherapy, radiotherapy and stem cell transplantation).
Beskrivelse
Inclusion Criteria:
- pediatric cancer patients receiving inpatient treatment with chemotherapy, -
- radiotherapy or stem cell transplantation
Exclusion Criteria:
- no informed consent
- no inpatient treatment
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: Kohorte
- Tidsperspektiver: Fremadrettet
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Arne Simon, MD, Children's Hospital Medical Center, University of Bonn, Germany
- Studieleder: Roland Ammann, MD, Children's Hosptial, Bern, Switzerland
- Studiestol: Hans-Jürgen Lawas, MD, Children's Hospital Medical Center, Düsseldorf, Germany
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Simon A, Fleischhack G, Hasan C, Bode U, Engelhart S, Kramer MH. Surveillance for nosocomial and central line-related infections among pediatric hematology-oncology patients. Infect Control Hosp Epidemiol. 2000 Sep;21(9):592-6. doi: 10.1086/501809.
- Simon A, Bode U, Fleischhack G, Kramer M. Surveillance of nosocomial infections in pediatric cancer patients. Am J Infect Control. 2005 Dec;33(10):611. doi: 10.1016/j.ajic.2005.09.005. No abstract available.
- Simon A, Fleischhack G, Wiszniewsky G, Hasan C, Bode U, Kramer MH. Influence of prolonged use of intravenous administration sets in paediatric cancer patients on CVAD-related bloodstream infection rates and hospital resources. Infection. 2006 Oct;34(5):258-63. doi: 10.1007/s15010-006-5646-y.
- Simon A, Groger N, Wilkesmann A, Hasan C, Wiszniewsky G, Engelhart S, Kramer MH, Bode U, Ammann RA, Fleischhack G. Restricted use of glycopeptides in paediatric cancer patients with fever and neutropenia. Int J Antimicrob Agents. 2006 Nov;28(5):417-22. doi: 10.1016/j.ijantimicag.2006.08.007. Epub 2006 Oct 12.
- Simon A, Besuden M, Vezmar S, Hasan C, Lampe D, Kreutzberg S, Glasmacher A, Bode U, Fleischhack G. Itraconazole prophylaxis in pediatric cancer patients receiving conventional chemotherapy or autologous stem cell transplants. Support Care Cancer. 2007 Feb;15(2):213-20. doi: 10.1007/s00520-006-0125-7. Epub 2006 Aug 30.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. marts 2007
Studieafslutning (Forventet)
1. juni 2010
Datoer for studieregistrering
Først indsendt
12. februar 2009
Først indsendt, der opfyldte QC-kriterier
12. februar 2009
Først opslået (Skøn)
13. februar 2009
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
28. juni 2010
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
25. juni 2010
Sidst verificeret
1. februar 2009
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 03/07
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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