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Anti-BK Virus Immune Response and Kidney Transplantation (BKv)

13. september 2021 opdateret af: Nantes University Hospital

Role of Specific Immune Cellular Response in the Control of BK Virus Infection: Prospective Study, Monocentric and Longitudinal During the First Nine Months After a Kidney Transplantation

BK virus infections are very frequent during months following a kidney transplantation: a viral reactivation is observed for almost 50% of patients during first year. This reactivation leads to a viremia for 10 to 15% of patient during this same period. The most frequent complication is interstitial nephritis for 2 to 8% of patients (27 patients representing 2.7% during 6 years in Nantes).

An intensive et persisting viral replication, assessed by detection of high blood viral load, could evolved to a viral nephropathy which lead to a very pejorative functional issue for the graft.

Biological follow-up of these infections lay on the measures of viral load. Their positivity must alert the physician and lead him to modulate immunosuppressive treatment.

Actually, there is no real consensus about the modalities of pharmacological immunosuppression decrease (decrease dose or change of molecule).

Specific lymphocytic anti-BKv evaluated on several cohorts of patients permit to prove:

  • weakness of immune cellular response for patient with high viremia
  • increase of this response when viral load decrease These studies laid on detection of INFg synthesis by Elispot after stimulation with viral antigens and in vitro cellular expansion.

New prospective and longitudinal data comparing the immune cellular response (systematic and early) after graft between patients controlling or not BKv infection are necessary to improve the comprehension of illness natural history.

The investigators propose to enlarge the investigation of anti-BKv immune cellular response to other functions than IFNg synthesis in the aim of detecting the eventual role of polyfunctional lymphocytes for infection control. Furthermore, the investigators propose to identify better diagnostic and prognostic makers.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

158

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Frankrig
      • Nantes, Frankrig, 44000
        • Nantes' Univeristy hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Kidney-transplanted person

Beskrivelse

Inclusion Criteria:

  • Kidney-transplanted patient, since less than 30 days
  • Older than 18 years old
  • Treatment with tacrolimus and mycophénolate mofetil

Exclusion Criteria:

  • No informed consent
  • Pregnant women
  • Patient under legal guardianship
  • Treated by ciclosporin or mTOR-inhibitor

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
kidney-transplanted patients
Andet: biological parameters
blood sample at M1, M2, M3; M4; M5, M6, M7, M8 and M9 after kidney transplantation

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Comparison of the level of response between patient with a "non-controlled infection" and patients for who the blood viral load is under 103 copBKv/ml.
Tidsramme: at 1month, 2months, 3months, 4, 5, 6, 7, 8 and 9 months after kidney transplantation
Analyse the role of T-lymphocytes response in the control of BKv infection
at 1month, 2months, 3months, 4, 5, 6, 7, 8 and 9 months after kidney transplantation

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Analyse of the other causes that could influence the occurence of a viremia higher than 103 copBKv/ml
Tidsramme: at 1month, 2months, 3months, 4, 5, 6, 7, 8 and 9 months after kidney transplantation
Other causes for abnormal viremia
at 1month, 2months, 3months, 4, 5, 6, 7, 8 and 9 months after kidney transplantation
Measurement of histological consequences of a BKv non-controlled infection during the first year post-graft
Tidsramme: at 12 months after kidney transplantation
Determine the frequence of occurence of nephropathy due to BKv for the population with a non-controlled infection
at 12 months after kidney transplantation
Measurement of increase of immune response due to modifications of immunosuppressive treatment for patient with a non-controlled infection
Tidsramme: at 1, 3 et 6 months after modification of immunosuppressive treatment
Comparision between the level of immune response and the time when the first viremia is higher than 103 copBKv/ml and 1, 3 et 6 months after modification of immunosuppressive treatment.
at 1, 3 et 6 months after modification of immunosuppressive treatment

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Nantes University Hospital

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

30. november 2010

Primær færdiggørelse (Faktiske)

26. august 2014

Studieafslutning (Faktiske)

1. september 2015

Datoer for studieregistrering

Først indsendt

21. april 2010

Først indsendt, der opfyldte QC-kriterier

22. april 2010

Først opslået (Skøn)

23. april 2010

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

17. september 2021

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

13. september 2021

Sidst verificeret

1. september 2021

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • BRD/10/03-ZF

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Nyretransplantation

Kliniske forsøg med biological parameters

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Sponsor / samarbejdspartnere

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