Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Dexmedetomidine in Children Having Transthoracic Echocardiography

28. juli 2017 opdateret af: Children's Hospital Medical Center, Cincinnati

A Qualitative Comparison of Oral Chloral Hydrate vs 2.0 or 3.0 mcg/kg Nasal Dexmedetomidine in Children Undergoing Transthoracic Echocardiography

Sedation Techniques for children undergoing transthoracic echocardiography (TTE).

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

The goal in this study is to determine if there is a significant difference in the quality of sedation between two standard sedation techniques and between two doses of dexmedetomidine for children undergoing (TTE).

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

279

Fase

  • Fase 4

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Kina
      • Shanghai, Kina
        • Shanghai Children's Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

3 måneder til 3 år (Barn)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Outpatients scheduled to receive sedation for transthoracic echocardiography
  • Subject must be a candidate for both types of anesthetic and both doses of dexmedetomidine
  • Must be 3 months to 36 months of age

Exclusion Criteria:

  • The subject has a history of cardiac conduction system disease (e.g. 1st or 2nd degree AV block) or channelopathy (e.g. long QT).
  • The subject is taking digoxin, alpha-adrenergic or beta-adrenergic agonist or antagonist (e.g., clonidine, propranolol, albuterol), anti-arrhythmic medications, or vasodilators (e.g. ACE inhibitors)
  • The subject has received a dose of any other sedative within 48 hours.
  • The subject has life-threatening, medical conditions (American Society of Anesthesiologists Physical Status 4, 5). The American Society of Anesthesiologists (ASA) classification scale is a measure of physical status or how healthy the patient is. For our study, we will focus on children which are defined as ASA I, II or III which means a healthy child (ASA I), a child with a systemic disease that is mild and well controlled (ASA II) or a child with systemic disease that is severe and controlled (ASA III).
  • The subject is allergic to or has a contraindication to any of the drugs used in the study.
  • The subject has previously been treated under this protocol.
  • The subject has severe coarctation of the aorta (risk of exaggerated vasoconstriction)
  • The subject has Moyamoya disease (risk of recurrent stroke)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Chloral Hydrate + placebo
Oral chloral hydrate sedation in flavored syrup plus nasal saline placebo
Medicin: Chloral Hydrate
70mg/kg chloral hydrate
Medicin: Placebo
Flavored placebo syrup
Aktiv komparator: Dexmedetomidine 2mcg/kg + placebo
Nasal dexmedetomidine sedation 2 mcg/kg plus oral flavored syrup placebo
Medicin: Placebo
Flavored placebo syrup
Medicin: Dexmedetomidine
2mcg/kg
Medicin: Dexmedetomidine
3mcg/kg
Aktiv komparator: Dexmedetomidine 3mcg/kg + placebo
Nasal dexmedetomidine sedation 3 mcg/kg plus oral flavored syrup placebo
Medicin: Placebo
Flavored placebo syrup
Medicin: Dexmedetomidine
2mcg/kg
Medicin: Dexmedetomidine
3mcg/kg

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Time to sedation
Tidsramme: 30 minutes
Achieve Ramsay sedation >3 within 30 minutes of administration of drug
30 minutes

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Duration of sedation level >3
Tidsramme: Patients will be followed for the duration of the procedure, average of 1 hour
Patients will be followed for the duration of the procedure, average of 1 hour
The number of sonographer pauses
Tidsramme: Participants will be followed for the duration of the procedure, average of 1 hour
The number of sonographer pauses over 2 minutes due to patient movement or medical interventions will be counted
Participants will be followed for the duration of the procedure, average of 1 hour
Need for rescue dexmedetomidine
Tidsramme: Participants will be followed for the duration of the procedure, average of 1 hour
The incidence of need for rescue nasal dexmedetomidine, due to patient arousal or movement prior to completion of TTE.
Participants will be followed for the duration of the procedure, average of 1 hour
Incidence of respiratory complications
Tidsramme: Participants will be followed for the duration of the hospital stay, average of 2 hours
Documentation of the incidence of respiratory complications
Participants will be followed for the duration of the hospital stay, average of 2 hours
Vital sign deviations of more than 30% from baseline
Tidsramme: Participants will be followed for the duration of the hospital stay, average of 2 hours
Documentation of the incidence of blood pressure or heart rate deviations of more than 30% from baseline. Baseline will be measured prior to sedative administration.
Participants will be followed for the duration of the hospital stay, average of 2 hours
Post anesthesia drowsiness
Tidsramme: Participants will be followed for the duration of the post procedure stay, average of 1 hour
Documentation of the incidence of post anesthesia drowsiness
Participants will be followed for the duration of the post procedure stay, average of 1 hour
Duration of Post Anesthesia Care Unit phase
Tidsramme: Participants will be followed for the duration of the post procedure stay, average of 1 hour
Documentation of the stay in Post Anesthesia Care Unit in minutes
Participants will be followed for the duration of the post procedure stay, average of 1 hour
Time to oral fluid intake
Tidsramme: Participants will be followed for the duration of the post procedure stay, average of 1 hour
Documentation of the time (in minutes) to oral fluid intake during the PACU phase
Participants will be followed for the duration of the post procedure stay, average of 1 hour
Time to discharge
Tidsramme: Participants will be followed for the duration of the post procedure stay, average of 1 hour
Documentation of the hospital stay after completion of the TTE.
Participants will be followed for the duration of the post procedure stay, average of 1 hour
Satisfaction of parents
Tidsramme: Up to 3 days
The satisfaction of the sedation technique will be completed by the parents by asking a series of questions during a follow-up phone call the next business day after the TTE.
Up to 3 days
Severity of respiratory complications
Tidsramme: Participants will be followed for the duration of the hospital stay, average of 2 hours
Documentation of the severity of respiratory complications
Participants will be followed for the duration of the hospital stay, average of 2 hours
Post anesthesia agitation
Tidsramme: Participants will be followed for the duration of the post procedure stay, average of 1 hour
Documentation of the incidence of post anesthesia agitation
Participants will be followed for the duration of the post procedure stay, average of 1 hour

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Children's Hospital Medical Center, Cincinnati

Efterforskere

  • Ledende efterforsker: Jeffrey Miller, MD, Children's Hospital Medical Center, Cincinnati

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. september 2014

Primær færdiggørelse (Faktiske)

1. maj 2017

Studieafslutning (Faktiske)

1. maj 2017

Datoer for studieregistrering

Først indsendt

27. juli 2015

Først indsendt, der opfyldte QC-kriterier

13. august 2015

Først opslået (Skøn)

14. august 2015

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

31. juli 2017

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. juli 2017

Sidst verificeret

1. juli 2017

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • SCMCIRB-K2014057

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Hjerte sygdom

Kliniske forsøg med Chloral Hydrate

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Spain

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner