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Infrared Imaging in Septic Illness

10. februar 2020 opdateret af: University Hospitals, Leicester

The Application of Infrared Thermal Imaging in the Diagnosis and Prognostication of Septic Illness in Adults

The application of infrared thermal imaging in the diagnosis and prognostication of septic illness in adults.

During times of severe infection (sepsis), the small blood vessels supplying oxygen and nutrients to the skin and other organs (called the microcirculation), become abnormal and do not function as they normally would in health. Monitoring these small blood vessels is difficult to do clinically and the investigators want to investigate a new way of doing this.

The aim of this study is to validate a novel method of assessing the function of the microcirculation in healthy volunteers and patients with sepsis, by measuring the skin temperature profile of the leg and face with a thermal imaging camera. Thermal imaging cameras measure the heat given off by all objects and represents this as a picture, with colour used to represent the different temperatures.

Patients will be recruited from the Emergency Department and Intensive Care Units at University Hospitals of Leicester in to one of two groups based on their illness severity; uncomplicated sepsis and severe sepsis. Healthy volunteers will be recruited in to a third group. Recruitment will take place over a 6-month period with follow-up lasting for 12-months following recruitment. 105 participants will be recruited in total.

Temperature patterns seen on the face and leg will be investigated between the different groups. Changes in these temperature patterns as patients recover from sepsis (or indeed become worse), will also be investigated. Information from the thermal images will be correlated to routinely measured markers of infection, including clinical measurements (blood pressure, pulse, etc) and routine blood investigations.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

112

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Det Forenede Kongerige
    • Leicestershire
      • Leicester, Leicestershire, Det Forenede Kongerige, LE1 5WW
        • University Hospitals of Leicester

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

This study will involve the recruitment of acutely unwell patients from the Emergency Department and Intensive Care Unit areas of the hospital, alongside healthy volunteers.

Beskrivelse

Inclusion Criteria:

  1. Male or Female, aged 18 years or above.
  2. Healthy volunteers - free from acute illness; will include staff and students at the University of Leicester and UHL, and patient relatives.
  3. Patient with septic illness will be recruited in to one of two groups depending on their disease severity - Sepsis (without evidence of organ dysfunction) or severe sepsis (with organ dysfunction).
  4. Able (in the Investigators opinion) and willing to comply with all study requirements.

Exclusion Criteria:

  1. Patient refusal
  2. Inability to gain appropriate assent/consent
  3. Children
  4. Prisoners or in police custody
  5. Skin marking likely to preclude image analysis (such as extensive tattoos).

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Observationsmodeller: Kohorte
  • Tidsperspektiver: Fremadrettet

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Sunde frivillige
Enhed: Infrared thermal imaging
Patients in all groups will undergo infrared thermal imaging of the face and anterior leg (centered on the knee)
Sepsis
Enhed: Infrared thermal imaging
Patients in all groups will undergo infrared thermal imaging of the face and anterior leg (centered on the knee)
Severe sepsis/septic shock
Enhed: Infrared thermal imaging
Patients in all groups will undergo infrared thermal imaging of the face and anterior leg (centered on the knee)

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Measure the extent of thermally apparent mottling of the anterior knee using a previously described mottling score.
Tidsramme: 18 months
Measure the extent of mottling (graded from 1 to 5) using the mottling score described by Ait-Oufella et al.
18 months
Measure core-peripheral temperature difference by means of a facial thermal image (Thermal Core-Peripheral Temperature Difference - TCPTD).
Tidsramme: 18 months
Thermal core-peripheral temperature difference (TCPTD) will be assessed using temperature at the medial canthus (core) and nasal (peripheral) in degrees centigrade.
18 months

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Association between the severity of thermally derived mottling score and the Sequential Organ Failure Assessment (SOFA) score.
Tidsramme: 18 months
Association between mottling score (graded 1-5) and illness severity as determined by the SOFA score (0-24).
18 months
Association between the severity of thermally derived mottling score and the APACHE II score.
Tidsramme: 18 months
Association between mottling score (1-5) and illness severity as determined by the APACHE II score (0-71).
18 months
Association between the extent of Thermal Core Peripheral Temperature Difference (TCPTD) and the SOFA score.
Tidsramme: 18 months
Associations between TCPTD (degrees centigrade) and illness severity as determined by the SOFA score (0-24).
18 months
Association between the extent of Thermal Core Peripheral Temperature Difference (TCPTD) and the APACHE II score.
Tidsramme: 18 months
Associations between TCPTD (degrees centigrade) and illness severity as determined by the APACHE II score (0-71).
18 months
Mortality at 30 days and 1 year from the point of enrollment.
Tidsramme: 18 months
Mortality information will be collected at 30 days and 1 year from the point of patient enrollment (0-6 months) and correlated to the thermally derived mottling score and thermal core-peripheral temperature difference to assess for potential prognostic value of the above investigations.
18 months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University Hospitals, Leicester

Samarbejdspartnere

Association of Anaesthetists of Great Britain and Ireland

Efterforskere

  • Ledende efterforsker: Jonathan Thompson, MB ChB, BSc, MD, University Hospitals, Leicester

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. juli 2016

Primær færdiggørelse (Faktiske)

1. februar 2019

Studieafslutning (Faktiske)

1. februar 2019

Datoer for studieregistrering

Først indsendt

20. juni 2016

Først indsendt, der opfyldte QC-kriterier

3. august 2016

Først opslået (Skøn)

4. august 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

11. februar 2020

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

10. februar 2020

Sidst verificeret

1. februar 2020

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • UHL 11486

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

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Kliniske forsøg med Sepsis

Kliniske forsøg med Infrared thermal imaging

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Sponsorer og samarbejdspartnere

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Betingelser

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Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

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