Advanced MRI Sequences in Multiple Sclerosis and Its Mimics (MS)
Role of Advanced MRI Sequences in Differentiating MS and Its Mimics
We aim to evaluate the role of conventional and advanced MRI sequences in:
- Establishing the diagnosis of multiple sclerosis and differentiate it from its mimics.
- Predict the prognosis and evaluate the treatment response in the first year of patients with multiple sclerosis.
Studieoversigt
Detaljeret beskrivelse
All patients in the study will be referred among those attend to Assuit university hospital with clinical symptoms suspicious of MS according to McDonald criteria 2017 with age range from (18-50 years old).
MRI study will be done for each patient. MRI study will be repeated for those already diagnosed as MS after starting the suitable treatment as decided by attending physician after one year to assess the efficacy of treatment and the patient prognosis.
MR imaging will be performed on a 1.5-T MR imaging unit (Siemens, Sembra medical system,German).
Prospectively completed data forms will be analyzed and compared. Statistical tests appropriate to the nature of the data will be used.
All patients will not be subjected to risk of any kind during this study. All patients' data will be confidentially kept. Approval of the ethical committee of Faculty of Medicine, Assiut University.
An informed consent will be taken from all patients included in this study.
- The research will be conducted only by scientifically qualified and trained personnel.
- The procedures included in this study have been already used in hospital and centers in and outside Egypt.
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- All patients in the study will be referred among those attend to Assuit university hospital with clinical symptoms suspicious of MS according to McDonald criteria 2017 with age range from (18-50 years old).
Exclusion Criteria:
o Any general contraindication of MRI in some cases as presence of paramagnetic substance as pacemakers or in patients with claustrophobia.
- Patient above 50 years old.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: Case-Control
- Tidsperspektiver: Fremadrettet
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
role of advanced MRI sequences in establishing the diagnosis of multiple sclerosis(MS)
Tidsramme: baseline
|
calculating the sensitivity,specificity and accuracy of diffusion tensor imaging (DTI) and dual inversion recovery(DIR) in differentiating MS from its mimics
|
baseline
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
follow up of MS patients after one year of treatment
Tidsramme: one year
|
assess the degree of brain atrophy after one year mainly in the white matter and cerebral cortex using 3DT1WI
|
one year
|
Samarbejdspartnere og efterforskere
Sponsor
Datoer for undersøgelser
Studer store datoer
Studiestart (Forventet)
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 17200227
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
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