A Physiological Profile of Recovery From Resistance, Endurance, and Mixed Exercise Types

A Physiological Profile of Recovery From Mechanical, Metabolic, and Mixed Exercise Stressors

Patrocinadores

Patrocinador principal: GlaxoSmithKline

Fuente GlaxoSmithKline
Resumen breve

The aim of this study to increase understanding of physiological and functional perturbations following a continuum of exercise stressors.

Descripción detallada

This study utilised a between groups design, with a within-groups control. This allowed the within-subject profiling of recovery during both a control and exercise week. This design also allowed each group to perform an ecologically valid exercise session as well as having markers of recovery tailored to the areas of interest specific to each cohort. By having each group perform a non-exercise control week, this gives valuable information on the reliability and smallest worthwhile change for a range of both novel and commonly used recovery markers.

Estado general Completed
Fecha de inicio January 1, 2016
Fecha de Terminación July 29, 2016
Fecha de finalización primaria July 29, 2016
Fase N/A
Tipo de estudio Interventional
Resultado primario
Medida Periodo de tiempo
Maximal isometric volume contraction (MIVC) Up to Day 26
Rate of force development (RFD) Up to Day 26
Countermovement jump (CMJ) Up to Day 26
20 meter (m) sprint assessment (Group 1 and 3 only) Up to Day 26
Cycling Time-Trial performance assessment (Group 2 only) Up to Day 26
Resultado secundario
Medida Periodo de tiempo
Sleep efficiency Up to Day 26
Sleep latency Up to Day 26
Time in bed Up to Day 26
Time asleep Up to Day 26
Perceived muscle soreness Up to Day 26
Perceived recovery measured by the daily analyses of life demands for athletes (DALDA) questionnaire Up to Day 26
Interleukin 10 (IL-10) Up to Day 26
Interleukin 6 (IL-6) Up to Day 26
C-reactive protein Up to Day 26
Neutrophils Up to Day 26
Creatine kinase Up to Day 26
F2-isoprostanes Up to Day 26
Protein carbonyls Up to Day 26
Fast myosin Up to Day 26
Slow myosin Up to Day 26
Matrix metalloproteinase-9 Up to Day 26
Limb Girth Up to Day 26
Range of motion (ROM) assessment Up to Day 26
Inscripción 24
Condición
Intervención

Tipo de intervención: Other

Nombre de intervención: Resistance exercise weight training session

Descripción: A resistance exercise session was performed. Following a warm-up that consisted of five-minutes cycling at a self-selected intensity, as well as three progressive lifts at 50, 75, and 90% 6 rep max (RM), participants performed four sets of six repetitions at 100% of 6RM (as determined by the maximal weight lifted during the maximal strength assessment) of the following lifts; back squat, front squat, good mornings, and Bulgarian split-squat. Two minutes rest was afforded between sets and exercises.

Etiqueta de grupo de brazo: Group1 (Resistance trained individuals)

Tipo de intervención: Other

Nombre de intervención: High-Intensity stochastic cycling session

Descripción: A high-intensity stochastic cycling session was performed. The cycling protocol was performed using a magnetically-braked cycle ergometer (Velotron, RacerMate). Following a 10 minute standardised warm-up including 3 × 3s sprints, participants completed a simulated road-race, consisting of sprints of varied length, differing work to rest ratios and short time-trials.

Etiqueta de grupo de brazo: Group 2 (Trained cyclists)

Tipo de intervención: Other

Nombre de intervención: Simulated Team sport protocol

Descripción: A simulated team sport protocol was performed. Participants performed a standardised warm-up consisting of performing three laps of the circuit jogging, and three laps at 50, 75, and 90% of perceived maximal speed. Participants were then afforded five minutes to perform self-selected stretching prior to commencing the session. Participants performed two sets of 45 minutes of the simulated team sport protocol, separated by 15 minutes rest. Each 45 minute period consisted of a one minute circuit repeated 45 times that replicates typical movement patterns observed during team sports and includes walking, jogging, jumping, sprinting, agility, and decelerations. Each circuit was initiated on the minute, therefore enabling participants to rest following the completion of each circuit. Pilot testing showed participants completes each circuit in approximately 48-55 seconds (sec) therefore enabling 5-12sec rest after each circuit.

Etiqueta de grupo de brazo: Group 3 (Team sports players)

Elegibilidad

Criterios:

Inclusion Criteria:

- Demonstrates understanding of the study procedures, restrictions and willingness to participate as evidenced by voluntary written informed consent (see Appendices 2-4) and has received a signed and dated copy of the informed consent form.

- Participant is male

- Good general and mental health as assessed by a health questionnaire and with, in the opinion of the investigator or medically qualified designee ,no clinically significant and relevant abnormalities in medical history or upon oral examination. As well as absence of any condition that would impact on the participant's safety or wellbeing or affect the individual's ability to understand and follow study procedures and requirements.

- Participants will be fully briefed prior to agreeing to participate in the study and the research team will confirm that they are willing, able, and likely to comply with all procedures and complete the study.

- Only the following individuals will be recruited as participants for the study:

Group 1: Resistance trained individuals (≥3 sessions per week for ≥2 years with a minimum of 1 session per week including leg-based exercises).

Group 2: Trained cyclists (competing at a minimum of Category 3 roadracing/ estimated 10 mile TT of <25 minutes and a training history of ≥5 hours per week for ≥2 years).

Group 3: Team sports players (minimum of University 1st team level e.g. soccer, rugby union, rugby league, hockey, and basketball, playing competitively ≥1x per week for ≥2 years).

Exclusion Criteria:

- Individuals that do not fit the training status inclusion criteria.

- Current use of any non-steroidal anti-inflammatory drugs (NSAID's) or other analgesics for pain relief.

- Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit.

- Previous participation in this study.

- Recent history (within the last 1 year) of alcohol or other substance abuse.

- An employee of the sponsor or the study site or members of their immediate family.

- Have a heart or any other medical condition that may contra-indicate participants from taking part in high intensity or exhaustive physical activity.

Género: Male

Edad mínima: 18 Years

Edad máxima: 35 Years

Voluntarios Saludables: Accepts Healthy Volunteers

Oficial general
Apellido Papel Afiliación
GSK Clinical Trials Study Director GlaxoSmithKline
Ubicación
Instalaciones: GSK Investigational Site
Ubicacion Paises

United Kingdom

Fecha de verificación

July 2017

Fiesta responsable

Tipo: Sponsor

Tiene acceso ampliado No
Número de brazos 3
Grupo de brazo

Etiqueta: Group1 (Resistance trained individuals)

Tipo: Other

Descripción: Resistance trained individuals (>3 sessions per weeks for ≥2 years with a minimum of 1 session per week including leg-based exercises)

Etiqueta: Group 2 (Trained cyclists)

Tipo: Other

Descripción: Trained cyclists (competing at a minimum of Category 3 road racing/estimated 10 mile TT of <25 minutes and a training history of ≥5 hours per week for ≥2 years)

Etiqueta: Group 3 (Team sports players)

Tipo: Other

Descripción: Team sports players (minimum of University 1st team level e.g. soccer, rugby union, rugby league, hockey and basketball, playing competitively ≥1x per week for ≥2 years)

Datos del paciente No
Información de diseño del estudio

Asignación: Non-Randomized

Modelo de intervención: Parallel Assignment

Propósito primario: Basic Science

Enmascaramiento: None (Open Label)

Fuente: ClinicalTrials.gov