Effect of Hepatic Impairment on LDE225..

Inclusion Criteria (all groups):

• Male and sterile or postmenopausal female age ≥18 to ≤70 years old.
• Normal Vital signs

Inclusion (group mild, moderate and severe hepatic impairment):

-Subjects with confirmed cirrhosis

Exclusion (all groups):

• Woman of childbearing potential and pregnant or lactating females or male not using condom
• Risk factors for torsades de pointes
• Clinically significant cardio-vascular disease
• severe or uncontrolled medical conditions
• Smokers consuming greater than 10 cigarettes or equivalent nicotine containing products per day.
• Use of investigational drugs (i.e. participation in any clinical investigation)

Exclusion for moderate, mild and severe groups:

• Symptoms or history of encephalopathy
• Clinical evidence of severe ascites

Exclusion Criteria:

-