진행성 거세 저항성 전립선암(CRPC) 치료를 위해 LHRH 작용제에서 황체 형성 호르몬 방출 호르몬(LHRH) 길항제로 전환하는 효능 연구

Inclusion Criteria:

• histologically confirmed adenocarcinoma of the prostate
• currently receiving LHRH agonist
• Anti-androgen oral therapy is permitted but will be discontinued upon enrollment
• PSA > 2 ng/ml
• rising PSA despite LHRH agonist
• patients may or may not have clinical evidence off metastases. If metastases are present, they must be asymptomatic and in bone or lymph node only
• Prior chemotherapy allowed
• ECOG performance status 0-1

Exclusion Criteria:

• Patients with a history of other active malignancies, except: adequately treated non-melanoma skin cancer, superficial bladder cancer, or other solid tumours curatively treated with no evidence of disease for ≥ 3 years.
• Other serious illness, psychiatric or medical condition that would not permit the patient to be managed according to the protocol including: i)Significant cardiovascular condition including but not limited to: uncontrolled hypertension, unstable angina, significant congestive heart failure or myocardial infarction, deep venous thrombosis, pulmonary embolus or cerebrovascular attack within the last 6 months. ii) History of significant neurological disorder that would impair the ability to obtain consent