- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT00295815
Enzastaurin Versus Lomustine i Glioblastom
10. september 2019 oppdatert av: Eli Lilly and Company
Randomisert fase 3 åpen undersøkelse - Enzastaurin vs. Lomustine i glioblastom
Denne protokollen vil teste aktiviteten til Enzastaurin vs. Lomustine i behandlingen av tilbakevendende hjernekreft (spesifikt intrakranielt glioblastoma multiforme).
Studieoversikt
Status
Fullført
Forhold
Intervensjon / Behandling
Studietype
Intervensjonell
Registrering (Faktiske)
397
Fase
- Fase 3
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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New South Wales
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Liverpool, New South Wales, Australia, 2170
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St Leonards, New South Wales, Australia, 2065
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Queensland
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Auchenflower, Queensland, Australia, 4066
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Victoria
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Heidelberg, Victoria, Australia, 3084
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Western Australia
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Nedlands, Western Australia, Australia, 6009
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Brussels, Belgia, 1200
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Leuven, Belgia, B-3000
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Liège, Belgia, 4000
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Ontario
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London, Ontario, Canada, N6A 4L6
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Ottawa, Ontario, Canada, K1H 1C4
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Toronto, Ontario, Canada, M5G 2M9
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Arizona
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Phoenix, Arizona, Forente stater, 85013
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Tucson, Arizona, Forente stater, 85724
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California
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Berkeley, California, Forente stater, 94704
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Los Angeles, California, Forente stater, 90048
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San Francisco, California, Forente stater, 94143
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Colorado
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Aurora, Colorado, Forente stater, 80010
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Delaware
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Newark, Delaware, Forente stater, 19718
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Florida
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Tampa, Florida, Forente stater, 33612
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Georgia
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Atlanta, Georgia, Forente stater, 30322
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Hawaii
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Honolulu, Hawaii, Forente stater, 96813
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Illinois
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Chicago, Illinois, Forente stater, 60611
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Peoria, Illinois, Forente stater, 61615
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Iowa
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Iowa City, Iowa, Forente stater, 52242
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Kansas
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Kansas City, Kansas, Forente stater, 66160
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Maryland
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Baltimore, Maryland, Forente stater, 21231
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Bethesda, Maryland, Forente stater, 20892
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Massachusetts
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Boston, Massachusetts, Forente stater, 02114
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Michigan
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Detroit, Michigan, Forente stater, 48202
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Minnesota
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Minneapolis, Minnesota, Forente stater, 55455
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Rochester, Minnesota, Forente stater, 55905
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Missouri
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Columbia, Missouri, Forente stater, 65203
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Saint Louis, Missouri, Forente stater, 63110
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Nebraska
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Omaha, Nebraska, Forente stater, 68114
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Nevada
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Las Vegas, Nevada, Forente stater, 89135
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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New Hampshire
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Lebanon, New Hampshire, Forente stater, 03756
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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New Mexico
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Albuquerque, New Mexico, Forente stater, 87106
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Santa Fe, New Mexico, Forente stater, 87505
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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New York
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Buffalo, New York, Forente stater, 14226
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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New York, New York, Forente stater, 10021
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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North Carolina
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Winston-Salem, North Carolina, Forente stater, 27157
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Ohio
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Columbus, Ohio, Forente stater, 43210
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Pennsylvania
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Pittsburgh, Pennsylvania, Forente stater, 15232
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Tennessee
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Memphis, Tennessee, Forente stater, 38138
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Nashville, Tennessee, Forente stater, 37203
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Texas
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Dallas, Texas, Forente stater, 75246
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Houston, Texas, Forente stater, 77030
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Lubbock, Texas, Forente stater, 79410
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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San Antonio, Texas, Forente stater, 78258
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Utah
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Salt Lake City, Utah, Forente stater, 84132
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Virginia
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Charlottesville, Virginia, Forente stater, 22908
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Washington
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Seattle, Washington, Forente stater, 98195
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Wisconsin
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Madison, Wisconsin, Forente stater, 53792
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Lyon, Frankrike, 69395
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Marseille, Frankrike, 13385
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Nancy, Frankrike, 54035
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Paris, Frankrike, 75013
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Poitiers, Frankrike, 86000
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Mumbai, India, 400 012
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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New Delhi, India, 110 029
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Vellore, India, 632 004
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Bologna, Italia, 40139
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Milano, Italia, 20133
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Napoli, Italia, 80131
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Roma, Italia, 00128
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Torino, Italia, 10126
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Ciudad Obregon, Mexico, 85100
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Guadalajara, Mexico, 44280
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Mexico City, Mexico, 11640
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Monterrey, Mexico, 64060
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Tijuana, Mexico, 22329
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Tlalpan, Mexico, 14269
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Toluca, Mexico, 52140
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Amsterdam, Nederland, 1105 AZ
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Den Haag, Nederland, 2512 VA
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Maastricht, Nederland, 6229 HX
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Rotterdam, Nederland, 3075 EA
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Lublin, Polen, 20-950
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Warsaw, Polen, 02-781
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Badalona, Spania, 08915
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Hospitalet Llobregat, Spania, 08907
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Madrid, Spania, 28040
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Oviedo, Spania, 33006
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Valencia, Spania, 46014
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Avon
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Bristol, Avon, Storbritannia, BS2 8ED
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Cambridgeshire
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Cambridge, Cambridgeshire, Storbritannia, CB2 2QQ
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Scotland
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Edinburgh, Scotland, Storbritannia, EH4 2XU
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Glasgow, Scotland, Storbritannia, G11 6NT
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Bonn, Tyskland, D-53105
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Dresden, Tyskland, 01307
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Freiburg, Tyskland, 79106
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Heidelberg, Tyskland, 69120
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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München, Tyskland, 81377
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Tübingen, Tyskland, 72076
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Graz, Østerrike, 8036
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Innsbruck, Østerrike, 5020
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Linz, Østerrike, A-4020
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Wien, Østerrike, A-1100
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år og eldre (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inklusjonskriterier:
- Pasienten har histologisk bekreftet diagnose av hjernekreft (spesifikt glioblastoma multiforme).
- Kreften din har kommet tilbake etter behandling.
- Pasienten kan ha gjennomgått tidligere operasjon for å fjerne kreft.
- Pasienten må kunne ta vare på seg selv.
Ekskluderingskriterier:
- Har en annen type kreft (bortsett fra tilstrekkelig behandlet basalcellekarsinom i huden). Pasient som har hatt en annen kreftsykdom tidligere, må være fri for kreft i mer enn 2 år.
- Har mottatt behandling innen de siste 30 dagene med et legemiddel som ikke har fått myndighetsgodkjenning for noen indikasjon ved innreise.
- Pasienter som får medisiner for anfall må avbryte behandlingen 14 dager før påmelding.
- Kan ikke gå på blodfortynnende medisiner ved studieopptak.
- Kan ikke gå på andre medisiner for å forebygge kreft ved studieopptak.
- Pasienter får ikke delta i studien hvis de tidligere har tatt Enzastaurin, Lomustine og/eller Bevacizumab.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
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Aktiv komparator: B
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100-130 mg/m2, oral en gang, hver 6. uke frem til PD
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Eksperimentell: EN
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1125 mg startdose deretter 500 mg, oral, daglig, 6 ukers sykluser frem til PD
Andre navn:
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Hovedmålet er å sammenligne Enzastaurin versus Lomustine hos pasienter som for andre gang har hjernekreft (spesielt intrakranielt glioblastom) for å se hvilken effekt medisinene har på å hindre sykdommen i å utvikle seg (forverres).
Tidsramme: baseline til målt progressiv sykdom (PD)
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baseline til målt progressiv sykdom (PD)
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Sekundære resultatmål
Resultatmål |
Tidsramme |
---|---|
Å måle overlevelse for å se hvordan svulsten reagerte på behandlingen og hvor lenge responsen varte ved bruk av MR (en skanningsteknikk).
Tidsramme: tidspunkt for respons på progressiv sykdom
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tidspunkt for respons på progressiv sykdom
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For å måle endringer i pasientens evne til å ta vare på seg selv (dette vil bli bestemt gjennom en standardundersøkelse).
Tidsramme: over hele studiet
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over hele studiet
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For å måle endringer fra baseline og en nevrologisk undersøkelse.
Tidsramme: baseline, hver syklus
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baseline, hver syklus
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Å gjennomgå alle dårlige reaksjoner rapportert av pasienten og oppdaget i blodprøver.
Tidsramme: hver syklus
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hver syklus
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Å gjennomgå effekten av kreften på pasientens evne til å ta vare på seg selv og på deres generelle helsetilstand.
Tidsramme: over hele studiet
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over hele studiet
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For å bestemme gjennom blodprøver hvor lenge medisinen er i pasientens kropp.
Tidsramme: syklus 1, syklus 4
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syklus 1, syklus 4
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Å gjennomgå gjennom testing av svulst- og blodprøver for å se om det er grunner til at noen pasienter responderte bedre på medisinene enn andre pasienter.
Tidsramme: baseline, syklus 2, studieslutt
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baseline, syklus 2, studieslutt
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. januar 2006
Primær fullføring (Faktiske)
1. august 2007
Studiet fullført (Faktiske)
1. mai 2014
Datoer for studieregistrering
Først innsendt
22. februar 2006
Først innsendt som oppfylte QC-kriteriene
22. februar 2006
Først lagt ut (Anslag)
24. februar 2006
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
12. september 2019
Siste oppdatering sendt inn som oppfylte QC-kriteriene
10. september 2019
Sist bekreftet
1. september 2019
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Neoplasmer etter histologisk type
- Neoplasmer
- Neoplasmer, kjertel og epitel
- Astrocytom
- Glioma
- Neoplasmer, Neuroepithelial
- Nevroektodermale svulster
- Neoplasmer, kjønnsceller og embryonale
- Neoplasmer, nervevev
- Glioblastom
- Molekylære mekanismer for farmakologisk virkning
- Antineoplastiske midler
- Antineoplastiske midler, Alkylering
- Alkyleringsmidler
- Lomustine
Andre studie-ID-numre
- 9817
- H6Q-MC-JCBF (Annen identifikator: Eli Lilly and Company)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
Ja
IPD-planbeskrivelse
Anonymiserte individuelle pasientnivådata vil bli gitt i et sikkert tilgangsmiljø ved godkjenning av et forskningsforslag og en signert datadelingsavtale.
IPD-delingstidsramme
Data er tilgjengelig 6 måneder etter den primære publisering og godkjenning av indikasjonen studert i USA og EU, avhengig av hva som er senere.
Data vil være tilgjengelig på ubestemt tid for forespørsel.
Tilgangskriterier for IPD-deling
Et forskningsforslag må godkjennes av et uavhengig granskningspanel og forskere må signere en datadelingsavtale.
IPD-deling Støtteinformasjonstype
- Studieprotokoll
- Statistisk analyseplan (SAP)
- Klinisk studierapport (CSR)
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
Kliniske studier på Glioblastom
-
Celldex TherapeuticsFullførtGlioblastom | Gliosarkom | Tilbakevendende glioblastom | Småcellet glioblastom | Kjempecelleglioblastom | Glioblastom med oligodendroglial komponent | Tilbakefallende glioblastomForente stater
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Northwestern UniversityNational Cancer Institute (NCI)RekrutteringGlioblastom | Astrocytom | Tilbakevendende glioblastom | MGMT-Umetylert glioblastom | Glioblastom, IDH-villtypeForente stater
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Istituto Oncologico Veneto IRCCSBayer S.p.ARekrutteringGlioblastom, IDH-villtype | MGMT-metylert glioblastomItalia
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Northwestern UniversityNational Cancer Institute (NCI); Moleculin Biotech, Inc.Har ikke rekruttert ennåMGMT-Umetylert glioblastom | Glioblastom, IDH-villtypeForente stater
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Massachusetts General HospitalHar ikke rekruttert ennåGlioblastom tilbakevendende, EGFR vIII mutant | Nydiagnostisert glioblastom, EGFRvIII-mutant | Tilbakevendende glioblastom, EGFR vIII negativForente stater
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City of Hope Medical CenterNational Cancer Institute (NCI)RekrutteringTilbakevendende glioblastom | Ildfast glioblastomForente stater
-
National Cancer Institute (NCI)SuspendertTilbakevendende glioblastom, IDH-Wildtype | MGMT-metylert glioblastom | Tilbakevendende MGMT-metylert glioblastomForente stater
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Northwestern UniversityAgenus Inc.; CarTheraRekrutteringGlioblastoma Multiforme | Gliosarkom | Nylig diagnostisert glioblastom | Glioblastom, isositrisk dehydrogenase (IDH)-villtypeForente stater
-
Celldex TherapeuticsFullførtGlioblastom | Gliosarkom | Småcellet glioblastom | Kjempecelleglioblastom | Glioblastom med oligodendroglial komponentForente stater, Canada, Australia, Israel, Taiwan, Storbritannia, Belgia, Frankrike, Spania, Tyskland, Østerrike, Brasil, Colombia, Tsjekkia, Hellas, Ungarn, India, Italia, Mexico, Nederland, New Zealand, Peru, Sveits, Thailand
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Hideho Okada, MD, PhDNational Cancer Institute (NCI); California Institute for Regenerative...RekrutteringGlioblastom | Tilbakevendende glioblastom | EGFR-genmutasjon | MGMT-Umetylert glioblastomForente stater
Kliniske studier på enzastaurin
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Eli Lilly and CompanyFullført
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Eli Lilly and CompanyFullførtLymfom, ondartet | Solid svulstKina
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Eli Lilly and CompanyFullførtT-celle lymfom | B-celle lymfomMexico, Forente stater, Australia, Brasil, Peru
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Eli Lilly and CompanyFullførtMantelcellelymfomAustralia, Frankrike, Tyskland, Nederland
-
Eli Lilly and CompanyFullført
-
Eli Lilly and CompanyFullførtLymfom, follikulærForente stater, Tyskland
-
Eli Lilly and CompanyFullførtLungekreftForente stater
-
Eli Lilly and CompanyFullførtPRELUDE: Studie for å undersøke forebygging av tilbakefall ved lymfom ved bruk av daglig enzastaurinNon Hodgkin lymfomForente stater, Kina, Spania, Polen, Taiwan, Belgia, Japan, Tyskland, Puerto Rico, Australia, Frankrike, Sverige, Hellas, Italia, India, Tsjekkia, Storbritannia, Canada, Korea, Republikken, Mexico, Danmark, Portugal, Finland, Brasil, Ungarn
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Aytu BioPharma, Inc.ParexelSuspendertVaskulært Ehlers-Danlos syndromForente stater
-
Eli Lilly and CompanyFullført