EuroSIDA - Klinisk og virologisk resultat av europeiske pasienter infisert med HIV (EuroSIDA)
10. april 2024 oppdatert av: Jens D Lundgren, MD, Rigshospitalet, Denmark
EuroSIDA prospektiv observasjonskohortstudie om kliniske og virologiske resultater av europeiske pasienter infisert med HIV
EuroSIDA-studien er en prospektiv observasjonskohortstudie av 23 000+ pasienter fulgt i 100+ klinikker i 35 europeiske land, Israel og Argentina. Studien er den største pan-europeiske kohortstudien og få studier med sammenlignbar design er tilgjengelig på global skala. EuroSIDA-studien er et pågående samarbeid og pasienter har blitt registrert i studien gjennom 11 kohorter siden 1994.
Hovedmålet med studien forblir det samme som i 1994: å prospektivt studere, kliniske, terapeutiske, demografiske, virologiske og laboratoriedata fra HIV-1 positive personer over hele Europa for å bestemme deres langsiktige virologiske, immunologiske og kliniske utfall.
Historisk har EuroSIDA vært avgjørende for å rapportere viktige endringer i HIV-epidemien, slik som de dramatiske endringene i sykelighet og dødelighet da antiretroviral kombinasjonsterapi (cART) først ble introdusert. Ettersom ny anti-HCV-behandling introduseres til HIV/HCV-infiserte pasienter, er det viktig for EuroSIDA å være i forkant med å undersøke behandlingsfordelene og bivirkninger.
Alle studiedokumenter, studiestatus, nyhetsbrev, vitenskapelige publikasjoner og presentasjoner er tilgjengelig online og oppdateres fortløpende på prosjektets hjemmeside.
Generelt sett er målet med EuroSIDA-studien å fortsette en langsiktig, prospektiv innsamling av kliniske, laboratorie- og terapeutiske data samt plasma på en stor kohort av påfølgende HIV-infiserte pasienter fra hele Europa for å (1) vurdere faktorene assosiert med det kliniske, immunologiske og virologiske forløpet av HIV-infeksjon og HIV-relaterte samtidige infeksjoner og komorbiditeter, og (2) fortsette å tilby og utvikle et overvåkingssystem for å beskrive tidsmessige endringer og regionale forskjeller i det kliniske forløpet til HIV og HIV-relaterte samtidige infeksjoner og komorbiditeter i Europa.
Studieoversikt
Status
Påmelding etter invitasjon
Detaljert beskrivelse
Sammendrag: Det er for tiden over 1½ million mennesker over hele Europa smittet med HIV. Epidemien fortsetter å forsterke seg i den østeuropeiske regionen hvor forekomsten av HIV vil fortsette å øke i årene som kommer. Det er betydelige problemer med håndteringen av denne folkehelsekrisen. Tilgjengelig antiretroviral terapi (ART) - selv om den er ekstremt effektiv - utrydder ikke HIV og må derfor fortsettes livet ut. Andre begrensninger er utvikling av resistens, uønskede effekter av behandlingen og kravet om streng etterlevelse. Til tross for disse begrensningene har den utbredte bruken av potent ART resultert i en dramatisk nedgang i HIV-relatert dødelighet over hele Europa. Ettersom forekomsten av AIDS har gått ned, har den relative betydningen av komorbiditeter og samtidige infeksjoner, som kronisk viral hepatitt og tuberkulose (TB), økt. Rundt en tredjedel av alle EuroSIDA-pasienter er samtidig infisert med hepatitt C-virus (HCV), og leverrelatert død er nå den nest vanligste dødsårsaken etter AIDS. Med introduksjonen av nye mer potente og bedre tolererte orale direktevirkende antivirale midler (DAA) mot HCV, forventes det store endringer i håndteringen og utfallet av HCV-koinfeksjon i de kommende årene. På grunn av de høye kostnadene ved DAA kan imidlertid tilgang til ny behandling variere betydelig i Europa.
Over 23 000 fortløpende registrerte HIV-1-positive pasienter fra over 100 kliniske sentre i 35 europeiske land, Israel og Argentina - en fjerdedel fra den østlige regionen - er for tiden registrert i EuroSIDA. Nye pasientkohorter registreres normalt hvert 2.-3. år for å sikre at alle regioner i Europa der epidemien er utbredt er representert, slik at studien vil gi rettidig informasjon om den kliniske presentasjonen og utfallet av europeiske HIV-1-positive pasienter. I 2012 ble ytterligere 2500 pasienter registrert i EuroSIDA-kohort IX. For å være i forkant av å undersøke fordeler og bivirkninger av ny HCV-behandling hos pasienter med samtidig infeksjon, besto EuroSIDA-kohorten X som ble registrert i 2014, av 4000 HIV-1-pasienter som var positive for antistoffer mot HCV. Neste kohort som skal registreres (kohort XI) i 2019 vil bestå av 1500 HIV-1 positive pasienter.
EuroSIDA-studiegruppen har nå jobbet med EuroSIDA-studien siden 1994 og har flere bemerkelsesverdige prestasjoner til dags dato, inkludert publisering av mer enn 200 artikler i fagfellevurderte tidsskrifter (inkludert New England Journal of Medicine og Lancet blant andre). Fokuset til EuroSIDA har naturlig nok endret seg i løpet av denne perioden, noe som viser en iver etter å være fleksibel, dynamisk og fokusere på moderne problemstillinger, og studiegruppen er forpliktet til å fortsette å jobbe med slike prinsipper.
EuroSIDA har de siste årene, i tillegg til de vitenskapelige publikasjonene, prioritert kapasitetsbygging i Øst-Europa med HIV-seminarer, vertskap for klinikere fra Øst-Europa som European AIDS Clinical Society (EACS)-studenter på kontoret til Copenhagen HIV Program og sponsing av 2-3 unge leger fra Øst-Europa til å delta på et statistisk kurs i London hvert år.
Mesteparten av dataene er samlet inn fra klinikkene som en del av rutinemessig behandling. I tillegg vil det sentrale plasmadepotet bli brukt til å utvide tidligere studier av virusepidemiologien til HIV (resistens og undertyper).
Primært studiemål: Å prospektivt studere kliniske, terapeutiske, demografiske, virologiske og laboratoriedata fra HIV-1-positive personer over hele Europa for å bestemme det langsiktige virologiske, immunologiske og kliniske resultatet. De spesifikke målene, som faller inn i fire hovedkategorier, er som følger:
- Å undersøke effekten av ART og faktorer som begrenser dette
- For å oppdage aktuelle eller nye uønskede hendelser med sent utbrudd blant pasienter på ART
- Å fortsette overvåking av HIV i klinikker rundt om i Europa for å beskrive tidsmessige endringer og regionale forskjeller
- Å overvåke opptaket og resultatet av HCV-behandling og utvikling av direktevirkende antivirale midler og sammenligne forskjeller mellom EuroSIDA-regioner
Studiebesøk: Registrering + oppfølging Datainnsamling: For alle HIV-1 positive pasienter som er registrert og under oppfølging, samles det inn laboratoriedata, terapeutiske og kliniske data om HIV, viral hepatitt og alvorlige ikke-AIDS kliniske hendelser, samt demografiske data og mulige data om graviditet og HIV-statusen til den nyfødte babyen. Pasientene blir sett på sine klinikker etter behov og i henhold til deres lokale lege. EuroSIDA innebærer ikke pasientintervjuer eller studiebesøk, informasjonen samles inn fra pasientnotater to ganger i året frem til 2017 heretter en gang i året.
Studietype
Observasjonsmessig
Registrering (Antatt)
23000
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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Buenos Aires, Argentina
- Hospital JM Ramos Mejia
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Antwerp, Belgia
- Institute of Tropical Medicine
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Brussels, Belgia
- CHU Saint-Pierre
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Gent, Belgia
- University Ziekenhuis Gent
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Sarajevo, Bosnia og Herzegovina
- Klinicki centar Univerziteta Sarajevo (KCUS)
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Copenhagen, Danmark
- Rigshospitalet
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Hillerød, Danmark
- Hilleroed Sygehus
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Hvidovre, Danmark
- Hvidovre Universitets Hospital
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Odense, Danmark
- Odense Universitetshospital
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Roskilde, Danmark
- Roskilde Sygehus
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Skejby, Danmark
- Aarhus Universitetshospital Skejby
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Kaliningrad, Den russiske føderasjonen
- Centre for HIV/AIDS & and infectious diseases
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Nizhny Novgorod, Den russiske føderasjonen
- Nizhny Novgorod Scientific and Research Institute
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St Petersburg, Den russiske føderasjonen
- St Petersburgs AIDS Centre
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Veliky Novgorod, Den russiske føderasjonen
- Novgorod Centre for AIDS prevention and control
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Kohtla-Järve, Estland
- Narva AIDS Centre
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Tallinn, Estland
- West-Tallinn Central Hospital
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Helsinki, Finland
- Helsinki University Central Hospital
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Bordeaux, Frankrike
- INSERM, Université Bordeaux Segalen
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Lyon, Frankrike
- Hôpital Edouard Herriot
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Lyon, Frankrike
- Hospital de la Croix Rousse
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Nice, Frankrike
- CHU Nice Hopital de l' Archet 1
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Paris, Frankrike
- Hôpital Necker-Enfants Malades
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Paris, Frankrike
- Hospital Saint Antoine
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Paris, Frankrike
- Hôpital de la Pitié-Salpétière
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Paris, Frankrike
- Hôtel-Dieu Hospital
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Tbilisi, Georgia
- Georgian AIDS and Clinical Immunology Research Center
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Athens, Hellas
- Ippokration General Hospital
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Athens, Hellas
- 1st I.K.A Hospital of Athens
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Athens, Hellas
- The General Hospital of Athens "G. Gennimatas"
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Gomel, Hviterussland
- GOCGEIOZ - Gomel Regional Centre for Hygiene
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Gomel, Hviterussland
- Gomel State Medical University
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Minsk, Hviterussland
- Belarus State Medical University
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Dublin, Irland
- St. James' Hospital
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Reykjavik, Island
- Landspitali University Hospital
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Haifa, Israel
- Rambam Health Care Campus
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Jerusalem, Israel
- Hadassah Hospital
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Rehovot, Israel
- Kaplan Medical Center, AIDS Center Neve Or
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Tel Aviv, Israel
- Ichilov Hospital
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Bergamo, Italia
- Ospedale Riuniti, Divisione Malattie Infettive
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Milano, Italia
- Ospedale L. Sacco
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Milano, Italia
- Ospedale San Raffaele
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Milano, Italia
- Ospedale San Paulo
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Modena, Italia
- Università degli Studi di Modena
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Napoli, Italia
- Ospedale Cotugno, III Divisione Malattie Infettive
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Rome, Italia
- National Institute for Infectious Diseases
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Rome, Italia
- Poloclinico Umberto 1
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Zagreb, Kroatia
- University Hospital of Infectious Diseases
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Riga, Latvia
- Infectology Center of Latvia
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Vilnius, Litauen
- Vilnius University Hospital Santariskiu Klinikos
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Vilnius, Litauen
- Infectious Diseases and Tuberculosis Hospital, Vilnius University Hospital branch
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Luxembourg, Luxembourg
- Centre Hospitalier de Luxembourg
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Amsterdam, Nederland
- Academisch Ziekenhuis bij de Universiteit van Amsterdam
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Oslo, Norge
- Oslo Universitetssykehus
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Bialystok, Polen
- Uniwersytecki Szpital Kliniczny
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Chorzow, Polen
- Szpital Specjalistyczny, Osrodek Diagnostyki i Terapii AIDS
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Gdansk, Polen
- Medical University Gdansk
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Lodz, Polen
- Wojewodzki Szpital Specjalistyczny im. WI. Bieganskiego
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Poznan, Polen
- Poznan University of Medical Sciences
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Szczecin, Polen
- Pomeramian Academy of Medicine (PAM)
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Warszawa, Polen
- Wojewodzki Szpital Zakazny
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Wroclaw, Polen
- EMC Instytut Medyczny SA
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Lisbon, Portugal
- Hospital Santa Maria
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Lisbon, Portugal
- Hospital Curry Cabral
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Lisbon, Portugal
- Hospital de Egas Moniz
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Bucuresti, Romania
- Dr. Victor Babes Hospital
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Belgrade, Serbia
- The Institute for Infectious and Tropical Diseases
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Bratislava, Slovakia
- Slovak Medical University
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Ljubljana, Slovenia
- University Clinical Centre Ljubljana
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Badalona, Spania
- Hospital Universitari Germans Trias i Pujol
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Barcelona, Spania
- Hospital de La Santa Creu I Sant Pau
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Barcelona, Spania
- Hospital Clinic, University of Barcelona
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Madrid, Spania
- Hospital Ramon y Cajal
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Madrid, Spania
- Hospital La Paz
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Madrid, Spania
- Hospital Carlos III, Departamento de Enfermedades Infecciosas
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Valencia, Spania
- Consorcio Hospital General Universitario Valencia
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Vitoria-Gasteiz, Spania
- Hospital Universitario de Alava
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Brighton, Storbritannia
- Royal Sussex County Hospital
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Edinburgh, Storbritannia
- Western General Hospital
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London, Storbritannia
- University College London
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London, Storbritannia
- St. Mary's Hospital
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London, Storbritannia
- Royal London Hospital
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London, Storbritannia
- University College London, Mortimer Market Centre
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Basel, Sveits
- University Hospital Basel
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Bern, Sveits
- University Hospital Bern
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Genève, Sveits
- Hopital Cantonal Universitaire Geneve
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Lausanne, Sveits
- Centre Hospitalier Universitaire Vaudois
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St.Gallen, Sveits
- Kantonsspital St. Gallen
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Zürich, Sveits
- University Hospital Zürich
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Malmö, Sverige
- Skåne University Hospital
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Stockholm, Sverige
- Sodersjukhuset
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Stockholm, Sverige
- Karolinska University Hospital Huddinge
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Plzeň, Tsjekkia
- Charles University Hospital Plzeň
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Prague, Tsjekkia
- Faculty Hospital Bulovka
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Bonn, Tyskland
- University Hospital Bonn
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Cologne, Tyskland
- University Hospital Cologne
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Eppendorf, Tyskland
- University Clinic Hamburg Eppendorf
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Frankfurt am Main, Tyskland
- J.W.Goethe University Hospital
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Hamburg, Tyskland
- ICH Study Center
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Hamburg, Tyskland
- Bernhard Nocht Institut für Tropenmedizin
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Hannover, Tyskland
- Mediziniche Hochschule Hannover
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München, Tyskland
- Ludwig-Maximilians-Universität, Medizinische Poliklinik
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Kharkiv, Ukraina
- Kharkiv State Medical University
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Luhansk, Ukraina
- Luhansk AIDS Center
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Lviv, Ukraina
- Lviv Regional HIV/AIDS Prevention and Control CTR
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Odessa, Ukraina
- Odessa Region AIDS Center
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Simferopol, Ukraina
- Crimean Republican AIDS centre
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Budapest, Ungarn
- Szent László Hospital
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Innsbruck, Østerrike
- Medical University Insbruck
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Vienna, Østerrike
- Otto Wagner Spital
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
16 år og eldre (Barn, Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Prøvetakingsmetode
Ikke-sannsynlighetsprøve
Studiepopulasjon
EuroSIDA-studien rekrutterer HIV-1-positive pasienter over 16 år i de proporsjonene de er representert i de deltakende klinikkene, noe som sikrer at kvinner er proporsjonalt representert i studien.
Omtrent 26 % av pasientene er kvinner.
Studien griper ikke inn i den kliniske behandlingen av pasientene som følges, men samler kun inn informasjon basert på leverandør-pasientintervjuer, fra pasientjournaler og fra innsamlede plasmaprøver.
Gravide kvinner kan delta i studien, da ingen forstyrrelse av deres behandling eller graviditet på noen måte vil finne sted.
Data om frekvens og utfall av graviditet samles inn i studien en gang i året.
Beskrivelse
Inklusjonskriterier:
- HIV-1-infiserte pasienter uavhengig av CD4-celletall og ART-status
- Må være positiv for antistoffer mot HCV uavhengig av HCV-RNA-status, fibrosestadium og tidligere HCV-behandling
Ekskluderingskriterier:
- Pasienter under 16 år
- Allerede registrert i EuroSIDA gjennom tidligere kohort
- Forhåndsdefinert antall pasienter er nådd
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
Kohorter og intervensjoner
Gruppe / Kohort |
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Kohort I
Påmeldt fra august 1994.
Pasienter som skulle inkluderes var de som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet).
For pasienter inkludert i studien fra 1994-1997 ble det bedt om at pasientene hadde en cluster of differentiation 4 (CD4) telling < 500 celler/µL i løpet av de siste 5 månedene før inklusjon.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort II
Påmeldt fra januar 1996.
Pasienter som skulle inkluderes var de som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet).
For pasienter inkludert i studien fra 1994-1997 ble det bedt om at pasientene hadde en cluster of differentiation 4 (CD4) telling < 500 celler/µL i løpet av de siste 5 månedene før inklusjon.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort III
Påmeldt fra februar 1997.
Pasienter som skulle inkluderes var de som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet).
For pasienter inkludert i studien fra 1994-1997 ble det bedt om at pasientene hadde en cluster of differentiation 4 (CD4) telling < 500 celler/µL i løpet av de siste 5 månedene før inklusjon.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort IV
Påmeldt fra mars 1999.
Pasienter som skulle inkluderes var de som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet).
Kvalifikasjonskriteriene for en klynge av differensiering 4 (CD4) teller < 500 celler/µL i løpet av de siste 5 månedene før inkludering er fjernet for pasienter som ble med i studien i 1999 og utover, siden intensjonen med studien er å inkludere de fleste kvalifiserte pasientene for antiretroviral terapi.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort V
Pasienter som skulle inkluderes var de i alderen 16 år eller eldre som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet), uavhengig av cluster of differentiation 4 (CD4) celletall.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort VI
Pasienter som skulle inkluderes var de i alderen 16 år eller eldre som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet), uavhengig av cluster of differentiation 4 (CD4) celletall.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort VII
Pasienter som skulle inkluderes var de i alderen 16 år eller eldre som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet), uavhengig av cluster of differentiation 4 (CD4) celletall.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort VIII
Pasienter som skulle inkluderes var de i alderen 16 år eller eldre som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet), uavhengig av cluster of differentiation 4 (CD4) celletall.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort IX
Påmeldt fra desember 2011.
Pasienter som skulle inkluderes var de i alderen 16 år eller eldre som besøkte poliklinikken for et planlagt besøk (dvs.
avtale mer enn 2 uker før besøkstidspunktet), uavhengig av cluster of differentiation 4 (CD4) celletall.
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort X
Alle pasienter bør være påfølgende pasienter (unntatt de som allerede er registrert i EuroSIDA), eller pasienter som hadde et planlagt besøk (dvs.
de som bestilte time >2 uker før besøket) i poliklinikken uavhengig av cluster of differentiation 4 (CD4) celletall og ART-status).
Registrer pasienter på 16 år eller eldre og positive for antistoffer mot hepatitt C-virus (uavhengig av HCV-RNA-status, fibrosestadium og tidligere behandling mot hepatitt C).
For alle HIV-pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske og kliniske data inn to ganger årlig.
Demografiske data, dato for graviditet og serologiske bevis for infeksjon med hepatitt B-virus (HBV) og hepatitt C-virus (HCV) samles inn én gang årlig.
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Kohort XI
HIV-1-positive personer ≥18 år, som ikke allerede er registrert i EuroSIDA, er kvalifisert for inkludering. Deltakere bør registreres fortløpende i en av følgende to grupper:
For alle pasienter som er registrert og under oppfølging, samles laboratoriedata, terapeutiske, kliniske og demografiske data, dato for graviditet og data om hepatitt B-virus (HBV) og hepatitt C-virus (HCV) inn én gang årlig. |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
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Forekomst av langsiktige virologiske, immunologiske og sykelighets- og dødelighetsutfall på tvers av ulike regioner i Europa; og demografiske, kliniske, terapeutiske og virale faktorer assosiert med disse resultatene
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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EuroSIDA er en ikke-intervensjonell epidemiologisk kohortstudie som samler inn strukturerte data.
Data samles ikke inn i sanntid, men i intervaller på 6 måneder.
De kliniske dataene er sentrert på innsamling av laboratorievariabler og påvisning av forhåndsdefinerte meningsfulle kliniske hendelser samt årsaker til å endre og/eller stoppe behandlingsregimer.
Konseptet med observasjonskohortstudier betyr at EuroSIDA ikke samler inn bivirkninger, bivirkninger, alvorlige bivirkninger eller mistenkte uventede alvorlige bivirkninger som definert av legemiddelovervåkingskrav for innehavere av markedsføringstillatelser.
Imidlertid analyserer og rapporterer EuroSIDA ofte spesifikke kliniske hendelser av interesse, noen ganger knyttet til legemiddelklasser, men mer regelmessig med fokus på regionale forskjeller i behandling og omsorg.
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
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Antall pasienter som opplever HIV-relaterte hendelser over tid
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Antall deltakere som opplever hiv-relaterte hendelser etter region
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Andel HCV-infiserte pasienter som starter behandling med direktevirkende antiretrovirale midler
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Frekvens for vedvarende virologisk respons 12 (SVR12) hos HCV-infiserte pasienter
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Andel pasienter med uoppdagbar viral belastning 12 uker etter avsluttet behandling rettet mot HCV-infeksjon
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Forekomst av leverrelaterte kliniske utfall hos HCV-infiserte pasienter som får HCV-behandling
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Forekomst av ikke-leverrelaterte kliniske utfall hos HCV-infiserte pasienter som får HCV-behandling
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Forekomst av leverrelaterte kliniske utfall hos HCV-infiserte pasienter som ikke får HCV-behandling
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Forekomst av ikke-leverrelaterte kliniske utfall hos HCV-infiserte pasienter som ikke får HCV-behandling
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Forekomst av toksisitet relatert til direkte virkende antivirale midler etter regioner
Tidsramme: Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Fra innmeldingsdato til progresjonsdato, tapt til oppfølging eller død, avhengig av hva som kom først, vurdert opp til 5 år
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Samarbeidspartnere
Etterforskere
- Studiestol: Gilles Wandeler, Dr. med., University of Bern, Switzerland.
Publikasjoner og nyttige lenker
Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.
Generelle publikasjoner
- Antiretroviral Therapy Cohort Collaboration. Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies. Clin Infect Dis. 2010 May 15;50(10):1387-96. doi: 10.1086/652283.
- Ledergerber B, Mocroft A, Reiss P, Furrer H, Kirk O, Bickel M, Uberti-Foppa C, Pradier C, D'Arminio Monforte A, Schneider MM, Lundgren JD; Eight European Study Groups. Discontinuation of secondary prophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection who have a response to antiretroviral therapy. Eight European Study Groups. N Engl J Med. 2001 Jan 18;344(3):168-74. doi: 10.1056/NEJM200101183440302.
- Weverling GJ, Mocroft A, Ledergerber B, Kirk O, Gonzales-Lahoz J, d'Arminio Monforte A, Proenca R, Phillips AN, Lundgren JD, Reiss P. Discontinuation of Pneumocystis carinii pneumonia prophylaxis after start of highly active antiretroviral therapy in HIV-1 infection. EuroSIDA Study Group. Lancet. 1999 Apr 17;353(9161):1293-8. doi: 10.1016/s0140-6736(99)03287-0.
- Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study Group; Sabin CA, Smith CJ, d'Arminio Monforte A, Battegay M, Gabiano C, Galli L, Geelen S, Gibb D, Guiguet M, Judd A, Leport C, Dabis F, Pantazis N, Porter K, Raffi F, Thorne C, Torti C, Walker S, Warszawski J, Wintergerst U, Chene G, Lundgren J. Response to combination antiretroviral therapy: variation by age. AIDS. 2008 Jul 31;22(12):1463-73. doi: 10.1097/QAD.0b013e3282f88d02.
- Hill A, Grossman H, Cohen C, Nadler J, Peeters M. Modelling-based prediction of clinical benefits from etravirine in the TMC125-C223 trial. HIV Clin Trials. 2007 Mar-Apr;8(2):68-76. doi: 10.1310/hct0802-68.
- Carter M. EuroSIDA cohort: 9% coinfected with HIV/HBV. IAPAC Mon. 2005 Apr;11(4):110. No abstract available.
- Podlekareva D, Grint D, Karpov I, Rakmanova A, Mansinho K, Chentsova N, Zeltina I, Losso M, Parczewski M, Lundgren JD, Mocroft A, Kirk O; EuroSIDA in EuroCoord. Changing utilization of Stavudine (d4T) in HIV-positive people in 2006-2013 in the EuroSIDA study. HIV Med. 2015 Oct;16(9):533-43. doi: 10.1111/hiv.12254. Epub 2015 May 18.
- Shepherd L, Borges AH, Ravn L, Harvey R, Jean-Paul V, Bower M, Grulich A, Silverberg M, De Wit S, Kirk O, Lundgren J, Mocroft A; EuroSIDA in Eurocoord. Predictive value of prostate-specific antigen for prostate cancer: a nested case-control study in EuroSIDA. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19510. doi: 10.7448/IAS.17.4.19510. eCollection 2014.
- Laut KG, Mocroft A, Lazarus J, Reiss P, Rockstroh J, Karpov I, Rakhmanova A, Knysz B, Moreno S, Gargalianos P, Lundgren J, Kirk O; Eurosida in Eurocoord. Regional differences in self-reported HIV care and management in the EuroSIDA study. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19504. doi: 10.7448/IAS.17.4.19504. eCollection 2014.
- Peters L, Mocroft A, Lundgren J, Grint D, Kirk O, Rockstroh J. HIV and hepatitis C co-infection in Europe, Israel and Argentina: a EuroSIDA perspective. BMC Infect Dis. 2014;14 Suppl 6(Suppl 6):S13. doi: 10.1186/1471-2334-14-S6-S13. Epub 2014 Sep 19. No abstract available.
- Grint D, Peters L, Schwarze-Zander C, Beniowski M, Pradier C, Battegay M, Jevtovic D, Soriano V, Lundgren JD, Rockstroh JK, Kirk O, Mocroft A; EuroSIDA in EuroCoord. Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA. HIV Med. 2013 Nov;14(10):614-23. doi: 10.1111/hiv.12068. Epub 2013 Jul 19.
- Podlekareva DN, Reekie J, Mocroft A, Losso M, Rakhmanova AG, Bakowska E, Karpov IA, Lazarus JV, Gatell J, Lundgren JD, Kirk O; EuroSIDA study in EuroCoord. Benchmarking HIV health care: from individual patient care to health care evaluation. An example from the EuroSIDA study. BMC Infect Dis. 2012 Sep 25;12:229. doi: 10.1186/1471-2334-12-229.
- Reekie J, Kowalska JD, Karpov I, Rockstroh J, Karlsson A, Rakhmanova A, Horban A, Kirk O, Lundgren JD, Mocroft A; EuroSIDA in EuroCoord. Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina: the EuroSIDA study. PLoS One. 2012;7(7):e41673. doi: 10.1371/journal.pone.0041673. Epub 2012 Jul 23.
- Fox ZV, Cozzi-Lepri A, D'Arminio Monforte A, Karlsson A, Phillips AN, Kronborg G, Kjaer J, Clotet B, Lundgren JD; EuroSIDA. Predictors of having a resistance test following confirmed virological failure of combination antiretroviral therapy: data from EuroSIDA. Antivir Ther. 2011;16(5):781-5. doi: 10.3851/IMP1801.
- Viard JP, Souberbielle JC, Kirk O, Reekie J, Knysz B, Losso M, Gatell J, Pedersen C, Bogner JR, Lundgren JD, Mocroft A; EuroSIDA Study Group. Vitamin D and clinical disease progression in HIV infection: results from the EuroSIDA study. AIDS. 2011 Jun 19;25(10):1305-15. doi: 10.1097/QAD.0b013e328347f6f7.
- Kowalska JD, Mocroft A, Ledergerber B, Florence E, Ristola M, Begovac J, Sambatakou H, Pedersen C, Lundgren JD, Kirk O; Eurosida Study Group. A standardized algorithm for determining the underlying cause of death in HIV infection as AIDS or non-AIDS related: results from the EuroSIDA study. HIV Clin Trials. 2011 Mar-Apr;12(2):109-17. doi: 10.1310/hct1202-109.
- Reekie J, Reiss P, Ledergerber B, Sedlacek D, Parczewski M, Gatell J, Katlama C, Fatkenheuer G, Lundgren JD, Mocroft A; EuroSIDA study group. A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study. HIV Med. 2011 May;12(5):259-68. doi: 10.1111/j.1468-1293.2010.00877.x. Epub 2010 Aug 31.
- van Luin M, Bannister WP, Mocroft A, Reiss P, Di Perri G, Peytavin G, Molto J, Karlson A, Castagna A, Beniowski M, Lundgren JD, Burger DM; EuroSIDA Study Group. Absence of a relation between efavirenz plasma concentrations and toxicity-driven efavirenz discontinuations in the EuroSIDA study. Antivir Ther. 2009;14(1):75-83.
- Podlekareva D, Bannister W, Mocroft A, Abrosimova L, Karpov I, Lundgren JD, Kirk O; EuroSIDA Study Group. The EuroSIDA study: Regional differences in the HIV-1 epidemic and treatment response to antiretroviral therapy among HIV-infected patients across Europe--a review of published results. Cent Eur J Public Health. 2008 Sep;16(3):99-105. doi: 10.21101/cejph.a3490.
- Bannister WP, Friis-Moller N, Mocroft A, Viard JP, van Lunzen J, Kirk O, Gargalianos P, Banhegyi D, Chiesi A, Lundgren JD; EuroSIDA Study Group. Incidence of abacavir hypersensitivity reactions in euroSIDA. Antivir Ther. 2008;13(5):687-96.
- Bannister WP, Cozzi-Lepri A, Clotet B, Mocroft A, Kjaer J, Reiss P, von Wyl V, Lazzarin A, Katlama C, Phillips AN, Ruiz L, Lundgren JD; EuroSIDA study group. Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination antiretroviral therapy in the EuroSIDA Study. J Acquir Immune Defic Syndr. 2008 Jul 1;48(3):324-33. doi: 10.1097/QAI.0b013e31817ae5c0.
- Bannister WP, Ruiz L, Cozzi-Lepri A, Mocroft A, Kirk O, Staszewski S, Loveday C, Karlsson A, Monforte Ad, Clotet B, Lundgren JD; EuroSIDA study group. Comparison of genotypic resistance profiles and virological response between patients starting nevirapine and efavirenz in EuroSIDA. AIDS. 2008 Jan 30;22(3):367-76. doi: 10.1097/QAD.0b013e3282f3cc35.
- Fessel J, Hurley LB. Incidence of pancreatitis in HIV-infected patients: comment on findings in EuroSIDA cohort. AIDS. 2008 Jan 2;22(1):145-7. doi: 10.1097/QAD.0b013e3282f030a9. No abstract available.
- Smith CJ, Olsen CH, Mocroft A, Viard JP, Staszewski S, Panos G, Staub T, Blaxhult A, Vetter N, Lundgren JD. The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study. AIDS. 2008 Jan 2;22(1):47-56. doi: 10.1097/QAD.0b013e3282f03094.
- Mocroft A, Ledergerber B, Zilmer K, Kirk O, Hirschel B, Viard JP, Reiss P, Francioli P, Lazzarin A, Machala L, Phillips AN, Lundgren JD; EuroSIDA study group and the Swiss HIV Cohort Study. Short-term clinical disease progression in HIV-1-positive patients taking combination antiretroviral therapy: the EuroSIDA risk-score. AIDS. 2007 Sep 12;21(14):1867-75. doi: 10.1097/QAD.0b013e328270b877.
- Podlekareva D, Mocroft A, Dragsted UB, Ledergerber B, Beniowski M, Lazzarin A, Weber J, Clumeck N, Vetter N, Phillips A, Lundgren JD; EuroSIDA study group. Factors associated with the development of opportunistic infections in HIV-1-infected adults with high CD4+ cell counts: a EuroSIDA study. J Infect Dis. 2006 Sep 1;194(5):633-41. doi: 10.1086/506366. Epub 2006 Jul 24.
- Konopnicki D, Mocroft A, de Wit S, Antunes F, Ledergerber B, Katlama C, Zilmer K, Vella S, Kirk O, Lundgren JD; EuroSIDA Group. Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort. AIDS. 2005 Mar 24;19(6):593-601. doi: 10.1097/01.aids.0000163936.99401.fe.
- Mocroft A, Monforte Ad, Kirk O, Johnson MA, Friis-Moller N, Banhegyi D, Blaxhult A, Mulcahy F, Gatell JM, Lundgren JD; EuroSIDA study group. Changes in hospital admissions across Europe: 1995-2003. Results from the EuroSIDA study. HIV Med. 2004 Nov;5(6):437-47. doi: 10.1111/j.1468-1293.2004.00250.x.
- Cabrera C, Cozzi-Lepri A, Phillips AN, Loveday C, Kirk O, Ait-Khaled M, Reiss P, Kjaer J, Ledergerber B, Lundgren JD, Clotet B, Ruiz L; EuroSIDA Study Group. Baseline resistance and virological outcome in patients with virological failure who start a regimen containing abacavir: EuroSIDA study. Antivir Ther. 2004 Oct;9(5):787-800.
- Mocroft A, Ledergerber B, Viard JP, Staszewski S, Murphy M, Chiesi A, Horban A, Hansen AB, Phillips AN, Lundgren JD; EuroSIDA Study Group. Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: results from the EuroSIDA study group. J Infect Dis. 2004 Dec 1;190(11):1947-56. doi: 10.1086/425424. Epub 2004 Oct 28.
- Kirk O, Mocroft A, Lundgren JD; EuroSIDA-studiet. [Decline in AIDS and death rates in the EuroSIDA study. An observational study]. Ugeskr Laeger. 2004 Jun 21;166(26-31):2572-6. No abstract available. Danish.
- Yust I, Fox Z, Burke M, Johnson A, Turner D, Mocroft A, Katlama C, Ledergerber B, Reiss P, Kirk O; EuroSIDA. Retinal and extraocular cytomegalovirus end-organ disease in HIV-infected patients in Europe: a EuroSIDA study, 1994-2001. Eur J Clin Microbiol Infect Dis. 2004 Jul;23(7):550-9. doi: 10.1007/s10096-004-1160-2. Epub 2004 Jun 30.
- Mocroft A, Kirk O, Clumeck N, Gargalianos-Kakolyris P, Trocha H, Chentsova N, Antunes F, Stellbrink HJ, Phillips AN, Lundgren JD. The changing pattern of Kaposi sarcoma in patients with HIV, 1994-2003: the EuroSIDA Study. Cancer. 2004 Jun 15;100(12):2644-54. doi: 10.1002/cncr.20309.
- Dragsted UB, Mocroft A, Vella S, Viard JP, Hansen AB, Panos G, Mercey D, Machala L, Horban A, Lundgren JD; EuroSIDA study group. Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: a EuroSIDA study. J Infect Dis. 2004 Jul 1;190(1):148-55. doi: 10.1086/420786. Epub 2004 Jun 9.
- d'Arminio Monforte A, Cinque P, Mocroft A, Goebel FD, Antunes F, Katlama C, Justesen US, Vella S, Kirk O, Lundgren J; EuroSIDA Study Group. Changing incidence of central nervous system diseases in the EuroSIDA cohort. Ann Neurol. 2004 Mar;55(3):320-8. doi: 10.1002/ana.10827.
- Blasko M. [EuroSIDA Study: downward trend of AIDS cases and AIDS mortality]. Dtsch Med Wochenschr. 2003 Sep 5;128(36):1814. No abstract available. German.
- Florence E, Lundgren J, Dreezen C, Fisher M, Kirk O, Blaxhult A, Panos G, Katlama C, Vella S, Phillips A; EuroSIDA Study Group. Factors associated with a reduced CD4 lymphocyte count response to HAART despite full viral suppression in the EuroSIDA study. HIV Med. 2003 Jul;4(3):255-62. doi: 10.1046/j.1468-1293.2003.00156.x.
- Mocroft A, Ledergerber B, Katlama C, Kirk O, Reiss P, d'Arminio Monforte A, Knysz B, Dietrich M, Phillips AN, Lundgren JD; EuroSIDA study group. Decline in the AIDS and death rates in the EuroSIDA study: an observational study. Lancet. 2003 Jul 5;362(9377):22-9. doi: 10.1016/s0140-6736(03)13802-0.
- Mocroft A, Brettle R, Kirk O, Blaxhult A, Parkin JM, Antunes F, Francioli P, D'Arminio Monforte A, Fox Z, Lundgren JD; EuroSIDA study group. Changes in the cause of death among HIV positive subjects across Europe: results from the EuroSIDA study. AIDS. 2002 Aug 16;16(12):1663-71. doi: 10.1097/00002030-200208160-00012.
- Mocroft A, Phillips AN, Friis-Moller N, Colebunders R, Johnson AM, Hirschel B, Saint-Marc T, Staub T, Clotet B, Lundgren JD; EuroSIDA study group. Response to antiretroviral therapy among patients exposed to three classes of antiretrovirals: results from the EuroSIDA study. Antivir Ther. 2002 Mar;7(1):21-30.
- Lundgren JD, Mocroft A, Gatell JM, Ledergerber B, D'Arminio Monforte A, Hermans P, Goebel FD, Blaxhult A, Kirk O, Phillips AN; EuroSIDA Study Group. A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: results from the EuroSIDA study. J Infect Dis. 2002 Jan 15;185(2):178-87. doi: 10.1086/338267. Epub 2002 Jan 3. Erratum In: J Infect Dis 2002 Jul 1;186(1):145.
- Blaxhult A, Mocroft A, Phillips A, van Lunzen J, Bentwich Z, Stergiou G, Colebunders R, Benfield TL, Mulcahy F, Lundgren JD. Does European or non-European origin influence health care and prognosis for HIV patients in Europe? The EuroSIDA Study Group. HIV Med. 1999 Oct;1(1):2-9. doi: 10.1046/j.1468-1293.1999.00002.x.
- Viard JP, Mocroft A, Chiesi A, Kirk O, Roge B, Panos G, Vetter N, Bruun JN, Johnson M, Lundgren JD; EuroSIDA Study Group. Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: evidence from the EuroSIDA study. J Infect Dis. 2001 Apr 15;183(8):1290-4. doi: 10.1086/319678. Epub 2001 Mar 26.
- Mocroft A, Phillips AN, Miller V, Gatell J, van Lunzen J, Parkin JM, Weber R, Roge B, Lazzarin A, Lundgren JD; EuroSIDA study group. The use of and response to second-line protease inhibitor regimens: results from the EuroSIDA study. AIDS. 2001 Jan 26;15(2):201-9. doi: 10.1097/00002030-200101260-00009.
- Mocroft A, Katlama C, Johnson AM, Pradier C, Antunes F, Mulcahy F, Chiesi A, Phillips AN, Kirk O, Lundgren JD. AIDS across Europe, 1994-98: the EuroSIDA study. Lancet. 2000 Jul 22;356(9226):291-6. doi: 10.1016/s0140-6736(00)02504-6.
- Kirk O, Gatell JM, Mocroft A, Pedersen C, Proenca R, Brettle RP, Barton SE, Sudre P, Phillips AN. Infections with Mycobacterium tuberculosis and Mycobacterium avium among HIV-infected patients after the introduction of highly active antiretroviral therapy. EuroSIDA Study Group JD. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):865-72. doi: 10.1164/ajrccm.162.3.9908018. Erratum In: Am J Respir Crit Care Med. 2003 Jun 15;167(12):1719.
- Mocroft A, Miller V, Chiesi A, Blaxhult A, Katlama C, Clotet B, Barton S, Lundgren JD. Virological failure among patients on HAART from across Europe: results from the EuroSIDA study. Antivir Ther. 2000 Jun;5(2):107-12.
- Paredes R, Mocroft A, Kirk O, Lazzarin A, Barton SE, van Lunzen J, Katzenstein TL, Antunes F, Lundgren JD, Clotet B. Predictors of virological success and ensuing failure in HIV-positive patients starting highly active antiretroviral therapy in Europe: results from the EuroSIDA study. Arch Intern Med. 2000 Apr 24;160(8):1123-32. doi: 10.1001/archinte.160.8.1123.
- Mocroft A, Madge S, Johnson AM, Lazzarin A, Clumeck N, Goebel FD, Viard JP, Gatell J, Blaxhult A, Lundgren JD. A comparison of exposure groups in the EuroSIDA study: starting highly active antiretroviral therapy (HAART), response to HAART, and survival. J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):369-78. doi: 10.1097/00126334-199912010-00008.
- Chiesi A, Mocroft A, Dally LG, Miller V, Katlama C, Ledergerber B, Pedersen C, Phillips AN, Arcieri R, Lundgren JD. Regional survival differences across Europe in HIV-positive people: the EuroSIDA study. AIDS. 1999 Nov 12;13(16):2281-8. doi: 10.1097/00002030-199911120-00010.
- Phillips AN, Grabar S, Tassie JM, Costagliola D, Lundgren JD, Egger M. Use of observational databases to evaluate the effectiveness of antiretroviral therapy for HIV infection: comparison of cohort studies with randomized trials. EuroSIDA, the French Hospital Database on HIV and the Swiss HIV Cohort Study Groups. AIDS. 1999 Oct 22;13(15):2075-82. doi: 10.1097/00002030-199910220-00010.
- Mocroft A, Kirk O, Barton SE, Dietrich M, Proenca R, Colebunders R, Pradier C, dArminio Monforte A, Ledergerber B, Lundgren JD. Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. EuroSIDA study group. AIDS. 1999 May 28;13(8):943-50. doi: 10.1097/00002030-199905280-00010.
- Miller V, Mocroft A, Reiss P, Katlama C, Papadopoulos AI, Katzenstein T, van Lunzen J, Antunes F, Phillips AN, Lundgren JD. Relations among CD4 lymphocyte count nadir, antiretroviral therapy, and HIV-1 disease progression: results from the EuroSIDA study. Ann Intern Med. 1999 Apr 6;130(7):570-7. doi: 10.7326/0003-4819-130-7-199904060-00005.
- Mocroft A, Vella S, Benfield TL, Chiesi A, Miller V, Gargalianos P, d'Arminio Monforte A, Yust I, Bruun JN, Phillips AN, Lundgren JD. Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group. Lancet. 1998 Nov 28;352(9142):1725-30. doi: 10.1016/s0140-6736(98)03201-2.
- Kirk O, Mocroft A, Katzenstein TL, Lazzarin A, Antunes F, Francioli P, Brettle RP, Parkin JM, Gonzales-Lahoz J, Lundgren JD. Changes in use of antiretroviral therapy in regions of Europe over time. EuroSIDA Study Group. AIDS. 1998 Oct 22;12(15):2031-9. doi: 10.1097/00002030-199815000-00015.
- Phillips AN, Katlama C, Barton S, Vella S, Blaxhult A, Clotet B, Goebel FD, Hirschel B, Pedersen C, Lundgren JD. Survival in 2367 zidovudine-treated patients according to use of other nucleoside analogue drugs. The EuroSIDA Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Mar 1;17(3):239-44. doi: 10.1097/00042560-199803010-00009.
- Lundgren JD, Phillips AN, Vella S, Katlama C, Ledergerber B, Johnson AM, Reiss P, Gatell J, Clumeck N, Dietrich M, Benfield TL, Nielsen JO, Pedersen C. Regional differences in use of antiretroviral agents and primary prophylaxis in 3122 European HIV-infected patients. EuroSIDA Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Nov 1;16(3):153-60. doi: 10.1097/00042560-199711010-00003.
- Vingerhoets J, Calvez V, Flandre P, Marcelin AG, Ceccherini-Silberstein F, Perno CF, Mercedes Santoro M, Bateson R, Nelson M, Cozzi-Lepri A, Grarup J, Lundgren J, Incardona F, Kaiser R, Sonnerborg A, Clotet B, Paredes R, Gunthard HF, Ledergerber B, Hoogstoel A, Nijs S, Tambuyzer L, Lavreys L, Opsomer M; Etravirine Cohort Study Group. Efficacy of etravirine combined with darunavir or other ritonavir-boosted protease inhibitors in HIV-1-infected patients: an observational study using pooled European cohort data. HIV Med. 2015 May;16(5):297-306. doi: 10.1111/hiv.12218. Epub 2015 Jan 14.
- Marzolini C, Sabin C, Raffi F, Siccardi M, Mussini C, Launay O, Burger D, Roca B, Fehr J, Bonora S, Mocroft A, Obel N, Dauchy FA, Zangerle R, Gogos C, Gianotti N, Ammassari A, Torti C, Ghosn J, Chene G, Grarup J, Battegay M; Efavirenz, Obesity Project Team on behalf of Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults. AIDS. 2015 Jan 14;29(2):193-200. doi: 10.1097/QAD.0000000000000530.
- Antiretroviral Therapy Cohort Collaboration (ART-CC); Vandenhende MA, Ingle S, May M, Chene G, Zangerle R, Van Sighem A, Gill MJ, Schwarze-Zander C, Hernandez-Novoa B, Obel N, Kirk O, Abgrall S, Guest J, Samji H, D'Arminio Monforte A, Llibre JM, Smith C, Cavassini M, Burkholder GA, Shepherd B, Crane HM, Sterne J, Morlat P. Impact of low-level viremia on clinical and virological outcomes in treated HIV-1-infected patients. AIDS. 2015 Jan 28;29(3):373-83. doi: 10.1097/QAD.0000000000000544. Erratum In: AIDS. 2015 Sep 10;29(14):1907.
- Boesecke C, Grint D, Soriano V, Lundgren JD, d'Arminio Monforte A, Mitsura VM, Chentsova N, Hadziosmanovic V, Kirk O, Mocroft A, Peters L, Rockstroh JK; EuroSIDA in EuroCoord. Hepatitis C seroconversions in HIV infection across Europe: which regions and patient groups are affected? Liver Int. 2015 Nov;35(11):2384-91. doi: 10.1111/liv.12848. Epub 2015 Apr 29.
- Bruyand M, Ryom L, Shepherd L, Fatkenheuer G, Grulich A, Reiss P, de Wit S, D Arminio Monforte A, Furrer H, Pradier C, Lundgren J, Sabin C; D:A:D study group. Cancer risk and use of protease inhibitor or nonnucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy: the D: A: D study. J Acquir Immune Defic Syndr. 2015 Apr 15;68(5):568-77. doi: 10.1097/QAI.0000000000000523.
- Mocroft A, Lundgren JD, Ross M, Law M, Reiss P, Kirk O, Smith C, Wentworth D, Neuhaus J, Fux CA, Moranne O, Morlat P, Johnson MA, Ryom L; D:A:D study group; Royal Free Hospital Clinic Cohort; INSIGHT study group; SMART study group; ESPRIT study group. Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study. PLoS Med. 2015 Mar 31;12(3):e1001809. doi: 10.1371/journal.pmed.1001809. eCollection 2015 Mar.
- Friis-Moller N, Ryom L, Smith C, Weber R, Reiss P, Dabis F, De Wit S, Monforte AD, Kirk O, Fontas E, Sabin C, Phillips A, Lundgren J, Law M; D:A:D study group. An updated prediction model of the global risk of cardiovascular disease in HIV-positive persons: The Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) study. Eur J Prev Cardiol. 2016 Jan;23(2):214-23. doi: 10.1177/2047487315579291. Epub 2015 Apr 16.
- Mansfeld M, Skrahina A, Shepherd L, Schultze A, Panteleev AM, Miller RF, Miro JM, Zeltina I, Tetradov S, Furrer H, Kirk O, Grzeszczuk A, Bolokadze N, Matteelli A, Post FA, Lundgren JD, Mocroft A, Efsen A, Podlekareva DN; TB:HIV study group in EuroCoord. Major differences in organization and availability of health care and medicines for HIV/TB coinfected patients across Europe. HIV Med. 2015 Oct;16(9):544-52. doi: 10.1111/hiv.12256. Epub 2015 May 11.
- Schultze A, Phillips AN, Paredes R, Battegay M, Rockstroh JK, Machala L, Tomazic J, Girard PM, Januskevica I, Gronborg-Laut K, Lundgren JD, Cozzi-Lepri A; EuroSIDA in EuroCOORD. HIV resistance testing and detected drug resistance in Europe. AIDS. 2015 Jul 17;29(11):1379-89. doi: 10.1097/QAD.0000000000000708.
- Achhra AC, Mocroft A, Reiss P, Sabin C, Ryom L, de Wit S, Smith CJ, d'Arminio Monforte A, Phillips A, Weber R, Lundgren J, Law MG; D:A:D Study Group. Short-term weight gain after antiretroviral therapy initiation and subsequent risk of cardiovascular disease and diabetes: the D:A:D study. HIV Med. 2016 Apr;17(4):255-68. doi: 10.1111/hiv.12294. Epub 2015 Jul 28.
- Grint D, Peters L, Rockstroh JK, Rakmanova A, Trofimova T, Lacombe K, Karpov I, Galli M, Domingo P, Kirk O, Lundgren JD, Mocroft A; EuroSIDA in EuroCoord. Liver-related death among HIV/hepatitis C virus-co-infected individuals: implications for the era of directly acting antivirals. AIDS. 2015 Jun 19;29(10):1205-15. doi: 10.1097/QAD.0000000000000674.
- Podlekareva DN, Panteleev AM, Grint D, Post FA, Miro JM, Bruyand M, Furrer H, Obel N, Girardi E, Vasilenko A, Losso MH, Arenas-Pinto A, Cayla J, Rakhmanova A, Zeltina I, Werlinrud AM, Lundgren JD, Mocroft A, Kirk O; HIV/TB study group. Short- and long-term mortality and causes of death in HIV/tuberculosis patients in Europe. Eur Respir J. 2014 Jan;43(1):166-77. doi: 10.1183/09031936.00138712. Epub 2013 Jun 13.
- Ryom L, Mocroft A, Kirk O, Ross M, Reiss P, Fux CA, Morlat P, Moranne O, Smith C, El-Sadr W, Law M, Lundgren JD. Predictors of advanced chronic kidney disease and end-stage renal disease in HIV-positive persons. AIDS. 2014 Jan 14;28(2):187-99. doi: 10.1097/QAD.0000000000000042.
- Zoufaly A, Cozzi-Lepri A, Reekie J, Kirk O, Lundgren J, Reiss P, Jevtovic D, Machala L, Zangerle R, Mocroft A, Van Lunzen J; EuroSIDA in EuroCoord. Immuno-virological discordance and the risk of non-AIDS and AIDS events in a large observational cohort of HIV-patients in Europe. PLoS One. 2014 Jan 31;9(1):e87160. doi: 10.1371/journal.pone.0087160. eCollection 2014.
- Grint D, Peters L, Rockstroh JK, de Wit S, Mitsura VM, Knysz B, Pedersen C, Kirk O, Lundgren JD, Mocroft A; EuroSIDA in EuroCoord. Increased incidence of antiretroviral drug discontinuation among patients with viremic hepatitis C virus coinfection and high hyaluronic acid, a marker of liver fibrosis. AIDS. 2014 Feb 20;28(4):577-87. doi: 10.1097/QAD.0000000000000069.
- Mocroft A, Ryom L, Reiss P, Furrer H, D'Arminio Monforte A, Gatell J, de Wit S, Beniowski M, Lundgren JD, Kirk O; EuroSIDA in EuroCOORD. A comparison of estimated glomerular filtration rates using Cockcroft-Gault and the Chronic Kidney Disease Epidemiology Collaboration estimating equations in HIV infection. HIV Med. 2014 Mar;15(3):144-52. doi: 10.1111/hiv.12095. Epub 2013 Oct 3.
- Shepherd L, Souberbielle JC, Bastard JP, Fellahi S, Capeau J, Reekie J, Reiss P, Blaxhult A, Bickel M, Leen C, Kirk O, Lundgren JD, Mocroft A, Viard JP; EuroSIDA in EuroCOORD. Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. J Infect Dis. 2014 Jul 15;210(2):234-43. doi: 10.1093/infdis/jiu074. Epub 2014 Feb 3.
- Mocroft A, Ryom L, Begovac J, Monforte AD, Vassilenko A, Gatell J, Florence E, Ormaasen V, Kirk O, Lundgren JD; EuroSIDA in EuroCOORD. Deteriorating renal function and clinical outcomes in HIV-positive persons. AIDS. 2014 Mar 13;28(5):727-37. doi: 10.1097/QAD.0000000000000134.
- Kamara DA, Ryom L, Ross M, Kirk O, Reiss P, Morlat P, Moranne O, Fux CA, Mocroft A, Sabin C, Lundgren JD, Smith CJ; D:A:D study Group. Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study. BMC Nephrol. 2014 Mar 25;15:51. doi: 10.1186/1471-2369-15-51.
- Engsig FN, Zangerle R, Katsarou O, Dabis F, Reiss P, Gill J, Porter K, Sabin C, Riordan A, Fatkenheuer G, Gutierrez F, Raffi F, Kirk O, Mary-Krause M, Stephan C, de Olalla PG, Guest J, Samji H, Castagna A, d'Arminio Monforte A, Skaletz-Rorowski A, Ramos J, Lapadula G, Mussini C, Force L, Meyer L, Lampe F, Boufassa F, Bucher HC, De Wit S, Burkholder GA, Teira R, Justice AC, Sterling TR, M Crane H, Gerstoft J, Grarup J, May M, Chene G, Ingle SM, Sterne J, Obel N; Antiretroviral Therapy Cohort Collaboration (ART-CC) and the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery. Clin Infect Dis. 2014 May;58(9):1312-21. doi: 10.1093/cid/ciu038. Epub 2014 Jan 22.
- Petoumenos K, Reiss P, Ryom L, Rickenbach M, Sabin CA, El-Sadr W, d'Arminio Monforte A, Phillips AN, De Wit S, Kirk O, Dabis F, Pradier C, Lundgren JD, Law MG; D:A:D study group. Increased risk of cardiovascular disease (CVD) with age in HIV-positive men: a comparison of the D:A:D CVD risk equation and general population CVD risk equations. HIV Med. 2014 Nov;15(10):595-603. doi: 10.1111/hiv.12162. Epub 2014 May 19.
- Peters L, Mocroft A, Soriano V, Rockstroh JK, Kirkby N, Reiss P, Katlama C, Zakharova N, Flisiak R, Lundgren JD; EuroSIDA in EuroCoord. High rate of hepatitis C virus (HCV) recurrence in HIV-infected individuals with spontaneous HCV RNA clearance. HIV Med. 2014 Nov;15(10):615-20. doi: 10.1111/hiv.12160. Epub 2014 May 11.
- Natural History Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. Factors associated with short-term changes in HIV viral load and CD4(+) cell count in antiretroviral-naive individuals. AIDS. 2014 Jun 1;28(9):1351-6. doi: 10.1097/QAD.0000000000000224.
- Ingle SM, May MT, Gill MJ, Mugavero MJ, Lewden C, Abgrall S, Fatkenheuer G, Reiss P, Saag MS, Manzardo C, Grabar S, Bruyand M, Moore D, Mocroft A, Sterling TR, D'Arminio Monforte A, Hernando V, Teira R, Guest J, Cavassini M, Crane HM, Sterne JA; Antiretroviral Therapy Cohort Collaboration. Impact of risk factors for specific causes of death in the first and subsequent years of antiretroviral therapy among HIV-infected patients. Clin Infect Dis. 2014 Jul 15;59(2):287-97. doi: 10.1093/cid/ciu261. Epub 2014 Apr 24.
- Smith CJ, Ryom L, Weber R, Morlat P, Pradier C, Reiss P, Kowalska JD, de Wit S, Law M, el Sadr W, Kirk O, Friis-Moller N, Monforte Ad, Phillips AN, Sabin CA, Lundgren JD; D:A:D Study Group. Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet. 2014 Jul 19;384(9939):241-8. doi: 10.1016/S0140-6736(14)60604-8.
- Mocroft A, Reiss P, Rakhmanova A, Banhegyi D, Phillips AN, De Wit S, Ristola M, Lundgren JD, Grarup J, Kirk O; EuroSIDA in EuroCOORD. A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe. Infection. 2014 Aug;42(4):757-62. doi: 10.1007/s15010-014-0630-4. Epub 2014 Jun 6.
- Socio-economic Inequalities and HIV Writing Group for Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord; Lodi S, Dray-Spira R, Touloumi G, Braun D, Teira R, D'Arminio Monforte A, Gallois A, Zangerle R, Spire B, Dabis F, Stahelin C, Termote M, Kirk O, Chene G, Egger M, del Amo J. Delayed HIV diagnosis and initiation of antiretroviral therapy: inequalities by educational level, COHERE in EuroCoord. AIDS. 2014 Sep 24;28(15):2297-306. doi: 10.1097/QAD.0000000000000410.
- Klein MB, Young J, Dunn D, Ledergerber B, Sabin C, Cozzi-Lepri A, Dabis F, Harrigan R, Tan DH, Walmsley S, Gill J, Cooper C, Scherrer AU, Mocroft A, Hogg RS, Smaill F; Canadian-European Clade Collaboration. The effects of HIV-1 subtype and ethnicity on the rate of CD4 cell count decline in patients naive to antiretroviral therapy: a Canadian-European collaborative retrospective cohort study. CMAJ Open. 2014 Oct 1;2(4):E318-29. doi: 10.9778/cmajo.20140017. eCollection 2014 Oct.
- Borges AH, Lundgren JD, Ridolfo A, Katlama C, Antunes F, Grzeszczuk A, Blaxhult A, Mitsura VM, Doroana M, Battegay M, Gargalianos P, Mocroft A; EuroSIDA in EuroCOORD. Thrombocytopenia is associated with an increased risk of cancer during treated HIV disease. AIDS. 2014 Nov 13;28(17):2565-71. doi: 10.1097/QAD.0000000000000433.
- Cozzi-Lepri A, Noguera-Julian M, Di Giallonardo F, Schuurman R, Daumer M, Aitken S, Ceccherini-Silberstein F, D'Arminio Monforte A, Geretti AM, Booth CL, Kaiser R, Michalik C, Jansen K, Masquelier B, Bellecave P, Kouyos RD, Castro E, Furrer H, Schultze A, Gunthard HF, Brun-Vezinet F, Paredes R, Metzner KJ; CHAIN Minority HIV-1 Variants Working Group. Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing. J Antimicrob Chemother. 2015 Mar;70(3):930-40. doi: 10.1093/jac/dku426. Epub 2014 Oct 21.
- Sogaard OS, Reekie J, Ristola M, Jevtovic D, Karpov I, Beniowski M, Servitskiy S, Domingo P, Reiss P, Mocroft A, Kirk O. Severe bacterial non-aids infections in HIV-positive persons: incidence rates and risk factors. J Infect. 2013 May;66(5):439-46. doi: 10.1016/j.jinf.2012.12.012. Epub 2013 Jan 24.
- Monforte Ad, Reiss P, Ryom L, El-Sadr W, Dabis F, De Wit S, Worm SW, Law MG, Weber R, Kirk O, Pradier C, Phillips AN, Lundgren JD, Sabin CA. Atazanavir is not associated with an increased risk of cardio- or cerebrovascular disease events. AIDS. 2013 Jan 28;27(3):407-15. doi: 10.1097/QAD.0b013e32835b2ef1.
- Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, Nattermann J, Lampe FC, Bucher HC, Sterling TR, Crane HM, Kitahata MM, May M, Sterne JA. An internationally generalizable risk index for mortality after one year of antiretroviral therapy. AIDS. 2013 Feb 20;27(4):563-72. doi: 10.1097/QAD.0b013e32835b8c7f.
- Podlekareva DN, Grint D, Post FA, Mocroft A, Panteleev AM, Miller RF, Miro JM, Bruyand M, Furrer H, Riekstina V, Girardi E, Losso MH, Cayla JA, Malashenkov EA, Obel N, Skrahina AM, Lundgren JD, Kirk O; HIV-TB Study Group. Health care index score and risk of death following tuberculosis diagnosis in HIV-positive patients. Int J Tuberc Lung Dis. 2013 Feb;17(2):198-206. doi: 10.5588/ijtld.12.0224.
- Pursuing Later Treatment Option II (PLATO II) Project Team of the Collaboration of Observational HIV Epidemiological Research Europe (COHERE); Costagliola D, Ledergerber B, Torti C, van Sighem A, Podzamczer D, Mocroft A, Dorrucci M, Masquelier B, de Luca A, Jansen K, De Wit S, Obel N, Fatkenheuer G, Touloumi G, Mussini C, Castagna A, Stephan C, Garcia F, Zangerle R, Duval X, Perez-Hoyos S, Meyer L, Ghosn J, Fabre-Colin C, Kjaer J, Chene G, Grarup J, Phillips A, Lodwick R, Torti C, Dorrucci M, Gunthard HF, Michalik C, Chrysos G, Castagna A. Predictors of CD4(+) T-cell counts of HIV type 1-infected persons after virologic failure of all 3 original antiretroviral drug classes. J Infect Dis. 2013 Mar 1;207(5):759-67. doi: 10.1093/infdis/jis752. Epub 2012 Dec 7.
- Abgrall S, Ingle SM, May MT, Costagliola D, Mercie P, Cavassini M, Reekie J, Samji H, Gill MJ, Crane HM, Tate J, Sterling TR, Antinori A, Reiss P, Saag MS, Mugavero MJ, Phillips A, Manzardo C, Wasmuth JC, Stephan C, Guest JL, Gomez Sirvent JL, Sterne JA; Antiretroviral Therapy Cohort Collaboration (ART-CC). Durability of first ART regimen and risk factors for modification, interruption or death in HIV-positive patients starting ART in Europe and North America 2002-2009. AIDS. 2013 Mar 13;27(5):803-13. doi: 10.1097/QAD.0b013e32835cb997. Erratum In: AIDS. 2014 Jul 31;28(12):1853.
- Sabin CA, Ryom L, Kovari H, Kirk O, de Wit S, Law M, Reiss P, Dabis F, Pradier C, El-Sadr W, Monforte Ad, Kamara D, Phillips AN, Lundgren JD. Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals: the D: A: D study. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):456-63. doi: 10.1097/QAI.0b013e318291cd29.
- Grint D, Peters L, Reekie J, Soriano V, Kirk O, Knysz B, Suetnov O, Lazzarin A, Ledergerber B, Rockstroh JK, Mocroft A; EuroSIDA in EuroCoord (European Coordinating Committee for the Integration of Ongoing Coordination Actions Related to Clinical and Epidemiological HIV Research). Stability of hepatitis C virus (HCV) RNA levels among interferon-naive HIV/HCV-coinfected individuals treated with combination antiretroviral therapy. HIV Med. 2013 Jul;14(6):370-8. doi: 10.1111/hiv.12033. Epub 2013 Mar 27.
- Mocroft A, Phillips AN, Gatell J, Horban A, Ledergerber B, Zilmer K, Jevtovic D, Maltez F, Podlekareva D, Lundgren JD; EuroSIDA study in EuroCOORD. CD4 cell count and viral load-specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use. AIDS. 2013 Mar 27;27(6):907-918. doi: 10.1097/QAD.0b013e32835cb766.
- Rockstroh JK, Peters L, Grint D, Soriano V, Reiss P, Monforte Ad, Beniowski M, Losso MH, Kirk O, Kupfer B, Mocroft A; EuroSIDA in EuroCoord. Does hepatitis C viremia or genotype predict the risk of mortality in individuals co-infected with HIV? J Hepatol. 2013 Aug;59(2):213-20. doi: 10.1016/j.jhep.2013.04.005. Epub 2013 Apr 11.
- Ryom L, Kirk O, Lundgren JD, Reiss P, Pedersen C, De Wit S, Buzunova S, Gasiorowski J, Gatell JM, Mocroft A; EuroSIDA in EuroCoord. Advanced chronic kidney disease, end-stage renal disease and renal death among HIV-positive individuals in Europe. HIV Med. 2013 Sep;14(8):503-8. doi: 10.1111/hiv.12038. Epub 2013 Apr 16.
- Ryom L, Mocroft A, Kirk O, Worm SW, Kamara DA, Reiss P, Ross M, Fux CA, Morlat P, Moranne O, Smith C, Lundgren JD; D:A:D Study Group. Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study. J Infect Dis. 2013 May 1;207(9):1359-69. doi: 10.1093/infdis/jit043. Epub 2013 Feb 4.
- Peters L, Mocroft A, Soriano V, Rockstroh J, Rauch A, Karlsson A, Knysz B, Pradier C, Zilmer K, Lundgren JD; for EuroSIDA in EuroCoord. Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients. PLoS One. 2013 May 27;8(5):e64283. doi: 10.1371/journal.pone.0064283. Print 2013.
- Kovari H, Sabin CA, Ledergerber B, Ryom L, Worm SW, Smith C, Phillips A, Reiss P, Fontas E, Petoumenos K, De Wit S, Morlat P, Lundgren JD, Weber R. Antiretroviral drug-related liver mortality among HIV-positive persons in the absence of hepatitis B or C virus coinfection: the data collection on adverse events of anti-HIV drugs study. Clin Infect Dis. 2013 Mar;56(6):870-9. doi: 10.1093/cid/cis919. Epub 2012 Oct 22.
- Mocroft A, Lundgren JD, Sabin ML, Monforte Ad, Brockmeyer N, Casabona J, Castagna A, Costagliola D, Dabis F, De Wit S, Fatkenheuer G, Furrer H, Johnson AM, Lazanas MK, Leport C, Moreno S, Obel N, Post FA, Reekie J, Reiss P, Sabin C, Skaletz-Rorowski A, Suarez-Lozano I, Torti C, Warszawski J, Zangerle R, Fabre-Colin C, Kjaer J, Chene G, Grarup J, Kirk O; Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in EuroCoord. Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE). PLoS Med. 2013;10(9):e1001510. doi: 10.1371/journal.pmed.1001510. Epub 2013 Sep 3.
- Kaulich-Bartz J, Dam W, May MT, Lederberger B, Widmer U, Phillips AN, Grabar S, Mocroft A, Vilaro J, van Sighem A, Moreno S, Dabis F, Monforte AD, Teira R, Ingle SM, Sterne JA; Writing Committee for the Antiretroviral Therapy Cohort Collaboration. Insurability of HIV-positive people treated with antiretroviral therapy in Europe: collaborative analysis of HIV cohort studies. AIDS. 2013 Jun 19;27(10):1641-55. doi: 10.1097/QAD.0b013e3283601199.
- Mocroft A, Furrer HJ, Miro JM, Reiss P, Mussini C, Kirk O, Abgrall S, Ayayi S, Bartmeyer B, Braun D, Castagna A, d'Arminio Monforte A, Gazzard B, Gutierrez F, Hurtado I, Jansen K, Meyer L, Munoz P, Obel N, Soler-Palacin P, Papadopoulos A, Raffi F, Ramos JT, Rockstroh JK, Salmon D, Torti C, Warszawski J, de Wit S, Zangerle R, Fabre-Colin C, Kjaer J, Chene G, Grarup J, Lundgren JD; Opportunistic Infections Working Group on behalf of the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in EuroCOORD. The incidence of AIDS-defining illnesses at a current CD4 count >/= 200 cells/muL in the post-combination antiretroviral therapy era. Clin Infect Dis. 2013 Oct;57(7):1038-47. doi: 10.1093/cid/cit423. Epub 2013 Aug 6.
- Worm SW, Bower M, Reiss P, Bonnet F, Law M, Fatkenheuer G, d'Arminio Monforte A, Abrams DI, Grulich A, Fontas E, Kirk O, Furrer H, De Wit S, Phillips A, Lundgren JD, Sabin CA; D:A:D Study Group. Non-AIDS defining cancers in the D:A:D Study--time trends and predictors of survival: a cohort study. BMC Infect Dis. 2013 Oct 9;13:471. doi: 10.1186/1471-2334-13-471.
- May MT, Ingle SM, Costagliola D, Justice AC, de Wolf F, Cavassini M, D'Arminio Monforte A, Casabona J, Hogg RS, Mocroft A, Lampe FC, Dabis F, Fatkenheuer G, Sterling TR, del Amo J, Gill MJ, Crane HM, Saag MS, Guest J, Brodt HR, Sterne JA; Antiretroviral Cohort Collaboration. Cohort profile: Antiretroviral Therapy Cohort Collaboration (ART-CC). Int J Epidemiol. 2014 Jun;43(3):691-702. doi: 10.1093/ije/dyt010. Epub 2013 Apr 18.
- Post FA, Grint D, Werlinrud AM, Panteleev A, Riekstina V, Malashenkov EA, Skrahina A, Duiculescu D, Podlekareva D, Karpov I, Bondarenko V, Chentsova N, Lundgren J, Mocroft A, Kirk O, Miro JM; HIV-TB Study Group. Multi-drug-resistant tuberculosis in HIV positive patients in Eastern Europe. J Infect. 2014 Mar;68(3):259-63. doi: 10.1016/j.jinf.2013.09.034. Epub 2013 Nov 16.
- Efsen AM, Panteleev AM, Grint D, Podlekareva DN, Vassilenko A, Rakhmanova A, Zeltina I, Losso MH, Miller RF, Girardi E, Cayla J, Post FA, Miro JM, Bruyand M, Furrer H, Obel N, Lundgren JD, Mocroft A, Kirk O; HIV/TB Study Group. TB meningitis in HIV-positive patients in Europe and Argentina: clinical outcome and factors associated with mortality. Biomed Res Int. 2013;2013:373601. doi: 10.1155/2013/373601. Epub 2013 Dec 31.
- Sabin CA, Ryom L, De Wit S, Mocroft A, Phillips AN, Worm SW, Weber R, D'Arminio Monforte A, Reiss P, Kamara D, El-Sadr W, Pradier C, Dabis F, Law M, Lundgren J; D:A:D Study Group. Associations between immune depression and cardiovascular events in HIV infection. AIDS. 2013 Nov 13;27(17):2735-48. doi: 10.1097/01.aids.0000432457.91228.f3.
- Kowalska JD, Reekie J, Mocroft A, Reiss P, Ledergerber B, Gatell J, d'Arminio Monforte A, Phillips A, Lundgren JD, Kirk O; EuroSIDA study group. Long-term exposure to combination antiretroviral therapy and risk of death from specific causes: no evidence for any previously unidentified increased risk due to antiretroviral therapy. AIDS. 2012 Jan 28;26(3):315-23. doi: 10.1097/QAD.0b013e32834e8805.
- Pursuing Later Treatment Option II (PLATO II) project team; Observational HIV Epidemiological Research Europe (COHERE) Group; Costagliola D, Lodwick R, Ledergerber B, Torti C, van Sighem A, Podzamczer D, Mocroft A, Dorrucci M, Masquelier B, de Luca A, Jansen K, De Wit S, Obel N, Fatkenheuer G, Touoloumi G, Mussini C, Castagna A, Stephan C, Garcia F, Zangerle R, Duval X, Perez-Hoyos S, Meyer L, Ghosn J, Fabre-Colin C, Kjaer J, Chene G, Grarup J, Phillips A. Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study. Lancet Infect Dis. 2012 Feb;12(2):119-27. doi: 10.1016/S1473-3099(11)70248-1. Epub 2011 Oct 9.
- Peters L, Grint D, Lundgren JD, Rockstroh JK, Soriano V, Reiss P, Grzeszczuk A, Sambatakou H, Mocroft A, Kirk O; EuroSIDA in EuroCoord. Hepatitis C virus viremia increases the incidence of chronic kidney disease in HIV-infected patients. AIDS. 2012 Sep 24;26(15):1917-26. doi: 10.1097/QAD.0b013e3283574e71.
- Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord; Lewden C, Bouteloup V, De Wit S, Sabin C, Mocroft A, Wasmuth JC, van Sighem A, Kirk O, Obel N, Panos G, Ghosn J, Dabis F, Mary-Krause M, Leport C, Perez-Hoyos S, Sobrino-Vegas P, Stephan C, Castagna A, Antinori A, d'Arminio Monforte A, Torti C, Mussini C, Isern V, Calmy A, Teira R, Egger M, Grarup J, Chene G. All-cause mortality in treated HIV-infected adults with CD4 >/=500/mm3 compared with the general population: evidence from a large European observational cohort collaboration. Int J Epidemiol. 2012 Apr;41(2):433-45. doi: 10.1093/ije/dyr164. Epub 2011 Nov 28.
- Worm SW, Kamara DA, Reiss P, Fontas E, De Wit S, El-Sadr W, D'Arminio Monforte A, Law M, Phillips A, Ryom L, Dabis F, Weber R, Sabin C, Lundgren JD; D:A:D Study Group. Evaluation of HIV protease inhibitor use and the risk of sudden death or nonhemorrhagic stroke. J Infect Dis. 2012 Feb 15;205(4):535-9. doi: 10.1093/infdis/jir788. Epub 2012 Jan 5.
- Petoumenos K, Worm SW, Fontas E, Weber R, De Wit S, Bruyand M, Reiss P, El-Sadr W, Monforte AD, Friis-Moller N, Lundgren JD, Law MG; D:A:D Study Group. Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. J Int AIDS Soc. 2012 Oct 10;15(2):17426. doi: 10.7448/IAS.15.2.17426.
- Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord; Young J, Psichogiou M, Meyer L, Ayayi S, Grabar S, Raffi F, Reiss P, Gazzard B, Sharland M, Gutierrez F, Obel N, Kirk O, Miro JM, Furrer H, Castagna A, De Wit S, Munoz J, Kjaer J, Grarup J, Chene G, Bucher H. CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. PLoS Med. 2012;9(3):e1001194. doi: 10.1371/journal.pmed.1001194. Epub 2012 Mar 20.
- Mocroft A, Bannister WP, Kirk O, Kowalska JD, Reiss P, D'Arminio-Monforte A, Gatell J, Fisher M, Trocha H, Rakhmanova A, Lundgren JD; EuroSIDA Study in EuroCOORD. The clinical benefits of antiretroviral therapy in severely immunocompromised HIV-1-infected patients with and without complete viral suppression. Antivir Ther. 2012;17(7):1291-300. doi: 10.3851/IMP2407. Epub 2012 Sep 26.
- HCV working group of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE) in EuroCoord. Effect of hepatitis C treatment on CD4+ T-cell counts and the risk of death in HIV-HCV-coinfected patients: the COHERE collaboration. Antivir Ther. 2012;17(8):1541-50. doi: 10.3851/IMP2263. Epub 2012 Jul 24.
- May MT, Hogg RS, Justice AC, Shepherd BE, Costagliola D, Ledergerber B, Thiebaut R, Gill MJ, Kirk O, van Sighem A, Saag MS, Navarro G, Sobrino-Vegas P, Lampe F, Ingle S, Guest JL, Crane HM, D'Arminio Monforte A, Vehreschild JJ, Sterne JA; Antiretroviral Therapy Cohort Collaboration (ART-CC). Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics. Int J Epidemiol. 2012 Dec;41(6):1807-20. doi: 10.1093/ije/dys164. Epub 2012 Nov 12.
- Murray M, Hogg RS, Lima VD, May MT, Moore DM, Abgrall S, Bruyand M, D'Arminio Monforte A, Tural C, Gill MJ, Harris RJ, Reiss P, Justice A, Kirk O, Saag M, Smith CJ, Weber R, Rockstroh J, Khaykin P, Sterne JA; Antiretroviral Therapy Cohort Collaboration (ART-CC). The effect of injecting drug use history on disease progression and death among HIV-positive individuals initiating combination antiretroviral therapy: collaborative cohort analysis. HIV Med. 2012 Feb;13(2):89-97. doi: 10.1111/j.1468-1293.2011.00940.x. Epub 2011 Aug 7.
- Bannister WP, Cozzi-Lepri A, Kjaer J, Clotet B, Lazzarin A, Viard JP, Kronborg G, Duiculescu D, Beniowski M, Machala L, Phillips A; EuroSIDA group. Estimating prevalence of accumulated HIV-1 drug resistance in a cohort of patients on antiretroviral therapy. J Antimicrob Chemother. 2011 Apr;66(4):901-11. doi: 10.1093/jac/dkr006. Epub 2011 Jan 31.
- Petoumenos K, Worm S, Reiss P, de Wit S, d'Arminio Monforte A, Sabin C, Friis-Moller N, Weber R, Mercie P, Pradier C, El-Sadr W, Kirk O, Lundgren J, Law M; D:A:D Study Group. Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D study(*). HIV Med. 2011 Aug;12(7):412-21. doi: 10.1111/j.1468-1293.2010.00901.x. Epub 2011 Jan 20.
- Kruk A, Bannister W, Podlekareva DN, Chentsova NP, Rakhmanova AG, Horban A, Domingo P, Mocroft A, Lundgren JD, Kirk O; EuroSIDA study group. Tuberculosis among HIV-positive patients across Europe: changes over time and risk factors. AIDS. 2011 Jul 31;25(12):1505-13. doi: 10.1097/QAD.0b013e328348fafd.
- Bohlius J, Schmidlin K, Boue F, Fatkenheuer G, May M, Caro-Murillo AM, Mocroft A, Bonnet F, Clifford G, Paparizos V, Miro JM, Obel N, Prins M, Chene G, Egger M; Collaboration of Observational HIV Epidemiological Research Europe. HIV-1-related Hodgkin lymphoma in the era of combination antiretroviral therapy: incidence and evolution of CD4(+) T-cell lymphocytes. Blood. 2011 Jun 9;117(23):6100-8. doi: 10.1182/blood-2010-08-301531. Epub 2011 Mar 2.
- Kowalska JD, Friis-Moller N, Kirk O, Bannister W, Mocroft A, Sabin C, Reiss P, Gill J, Lewden C, Phillips A, D'Arminio Monforte A, Law M, Sterne J, De Wit S, Lundgren JD; CoDe Working Group; D:A:D Study Group. The Coding Causes of Death in HIV (CoDe) Project: initial results and evaluation of methodology. Epidemiology. 2011 Jul;22(4):516-23. doi: 10.1097/EDE.0b013e31821b5332.
- Soriano V, Grint D, d'Arminio Monforte A, Horban A, Leen C, Poveda E, Antunes F, de Wit S, Lundgren J, Rockstroh J, Peters L. Hepatitis delta in HIV-infected individuals in Europe. AIDS. 2011 Oct 23;25(16):1987-92. doi: 10.1097/QAD.0b013e32834babb3.
- Reekie J, Gatell JM, Yust I, Bakowska E, Rakhmanova A, Losso M, Krasnov M, Francioli P, Kowalska JD, Mocroft A; EuroSIDA in EuroCoord. Fatal and nonfatal AIDS and non-AIDS events in HIV-1-positive individuals with high CD4 cell counts according to viral load strata. AIDS. 2011 Nov 28;25(18):2259-68. doi: 10.1097/QAD.0b013e32834cdb4b.
- Paredes R, Puertas MC, Bannister W, Kisic M, Cozzi-Lepri A, Pou C, Bellido R, Betancor G, Bogner J, Gargalianos P, Banhegyi D, Clotet B, Lundgren J, Menendez-Arias L, Martinez-Picado J; EuroSIDA Study Group. A376S in the connection subdomain of HIV-1 reverse transcriptase confers increased risk of virological failure to nevirapine therapy. J Infect Dis. 2011 Sep 1;204(5):741-52. doi: 10.1093/infdis/jir385.
- Cozzi-Lepri A, Prosperi MC, Kjaer J, Dunn D, Paredes R, Sabin CA, Lundgren JD, Phillips AN, Pillay D; EuroSIDA Study; United Kingdom CHIC/United Kingdom HDRD Study. Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score. PLoS One. 2011;6(11):e25665. doi: 10.1371/journal.pone.0025665. Epub 2011 Nov 16.
- Cozzi-Lepri A, Paredes, Phillips AN, Clotet B, Kjaer J, Von Wyl V, Kronborg G, Castagna A, Bogner JR, Lundgren JD; EuroSIDA in EuroCoord. The rate of accumulation of nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in patients kept on a virologically failing regimen containing an NNRTI*. HIV Med. 2012 Jan;13(1):62-72. doi: 10.1111/j.1468-1293.2011.00943.x. Epub 2011 Aug 17.
- Worm SW, Kamara DA, Reiss P, Kirk O, El-Sadr W, Fux C, Fontas E, Phillips A, D'Arminio Monforte A, De Wit S, Petoumenos K, Friis-Mller N, Mercie P, Lundgren JD, Sabin C. Elevated triglycerides and risk of myocardial infarction in HIV-positive persons. AIDS. 2011 Jul 31;25(12):1497-504. doi: 10.1097/QAD.0b013e32834917c6.
- Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study. The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: the D:A:D study. J Infect Dis. 2011 Aug 15;204(4):521-5. doi: 10.1093/infdis/jir329.
- Pursuing Later Treatment Options II (PLATO II) project team; Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Group; Nakagawa F, Lodwick R, Costagliola D, van Sighem A, Torti C, Podzamczer D, Mocroft A, Ledergerber B, Dorrucci M, Cozzi-Lepri A, Jansen K, Masquelier B, Garcia F, De Wit S, Stephan C, Obel N, Fatkenhaeuer G, Castagna A, Sambatakou H, Mussini C, Ghosn J, Zangerle R, Duval X, Meyer L, Perez-Hoyos S, Fabre Colin C, Kjaer J, Chene G, Grarup J, Phillips A. Calendar time trends in the incidence and prevalence of triple-class virologic failure in antiretroviral drug-experienced people with HIV in Europe. J Acquir Immune Defic Syndr. 2012 Mar 1;59(3):294-9. doi: 10.1097/QAI.0b013e31823fe66b.
- Wittkop L, Gunthard HF, de Wolf F, Dunn D, Cozzi-Lepri A, de Luca A, Kucherer C, Obel N, von Wyl V, Masquelier B, Stephan C, Torti C, Antinori A, Garcia F, Judd A, Porter K, Thiebaut R, Castro H, van Sighem AI, Colin C, Kjaer J, Lundgren JD, Paredes R, Pozniak A, Clotet B, Phillips A, Pillay D, Chene G; EuroCoord-CHAIN study group. Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study. Lancet Infect Dis. 2011 May;11(5):363-71. doi: 10.1016/S1473-3099(11)70032-9. Epub 2011 Feb 25.
- Reekie J, Mocroft A, Ledergerber B, Beniowski M, Clotet B, van Lunzen J, Chiesi A, Pradier C, Machala L, Lundgren JD; EuroSIDA Study Group. History of viral suppression on combination antiretroviral therapy as a predictor of virological failure after a treatment change. HIV Med. 2010 Aug;11(7):469-78. doi: 10.1111/j.1468-1293.2009.00816.x. Epub 2010 Feb 22.
- Soriano V, Mocroft A, Peters L, Rockstroh J, Antunes F, Kirkby N, de Wit S, Monforte Ad, Flisiak R, Lundgren J; EuroSIDA. Predictors of hepatitis B virus genotype and viraemia in HIV-infected patients with chronic hepatitis B in Europe. J Antimicrob Chemother. 2010 Mar;65(3):548-55. doi: 10.1093/jac/dkp479. Epub 2010 Jan 5.
- Pursuing Later Treatment Options II (PLATO II) Project Team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE); Lodwick R, Costagliola D, Reiss P, Torti C, Teira R, Dorrucci M, Ledergerber B, Mocroft A, Podzamczer D, Cozzi-Lepri A, Obel N, Masquelier B, Staszewski S, Garcia F, De Wit S, Castagna A, Antinori A, Judd A, Ghosn J, Touloumi G, Mussini C, Duval X, Ramos J, Meyer L, Warsawski J, Thorne C, Masip J, Perez-Hoyos S, Pillay D, van Sighem A, Lo Caputo S, Gunthard H, Paredes R, De Luca A, Paraskevis D, Fabre-Colin C, Kjaer J, Chene G, Lundgren JD, Phillips AN. Triple-class virologic failure in HIV-infected patients undergoing antiretroviral therapy for up to 10 years. Arch Intern Med. 2010 Mar 8;170(5):410-9. doi: 10.1001/archinternmed.2009.472.
- Reekie J, Kosa C, Engsig F, Monforte Ad, Wiercinska-Drapalo A, Domingo P, Antunes F, Clumeck N, Kirk O, Lundgren JD, Mocroft A; EuroSIDA Study Group. Relationship between current level of immunodeficiency and non-acquired immunodeficiency syndrome-defining malignancies. Cancer. 2010 Nov 15;116(22):5306-15. doi: 10.1002/cncr.25311.
- Mocroft A, Kirk O, Reiss P, De Wit S, Sedlacek D, Beniowski M, Gatell J, Phillips AN, Ledergerber B, Lundgren JD; EuroSIDA Study Group. Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients. AIDS. 2010 Jul 17;24(11):1667-78. doi: 10.1097/QAD.0b013e328339fe53.
- Opportunistic Infections Project Team of the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE); Mocroft A, Reiss P, Kirk O, Mussini C, Girardi E, Morlat P, Stephan C, De Wit S, Doerholt K, Ghosn J, Bucher HC, Lundgren JD, Chene G, Miro JM, Furrer H. Is it safe to discontinue primary Pneumocystis jiroveci pneumonia prophylaxis in patients with virologically suppressed HIV infection and a CD4 cell count <200 cells/microL? Clin Infect Dis. 2010 Sep 1;51(5):611-9. doi: 10.1086/655761. Erratum In: Clin Infect Dis. 2010 Nov 1;51(9):1114.
- Mocroft A, Phillips AN, Ledergerber B, Smith C, Bogner JR, Lacombe K, Wiercinska-Drapalo A, Reiss P, Kirk O, Lundgren JD; EuroSIDA Study Group. Estimated average annual rate of change of CD4(+) T-cell counts in patients on combination antiretroviral therapy. Antivir Ther. 2010;15(4):563-70. doi: 10.3851/IMP1559.
- Trullas JC, Mocroft A, Cofan F, Tourret J, Moreno A, Bagnis CI, Fux CA, Katlama C, Reiss P, Lundgren J, Gatell JM, Kirk O, Miro JM; EuroSIDA Investigators. Dialysis and renal transplantation in HIV-infected patients: a European survey. J Acquir Immune Defic Syndr. 2010 Dec 15;55(5):582-9. doi: 10.1097/QAI.0b013e3181efbe59.
- Friis-Moller N, Thiebaut R, Reiss P, Weber R, Monforte AD, De Wit S, El-Sadr W, Fontas E, Worm S, Kirk O, Phillips A, Sabin CA, Lundgren JD, Law MG; DAD study group. Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study. Eur J Cardiovasc Prev Rehabil. 2010 Oct;17(5):491-501. doi: 10.1097/HJR.0b013e328336a150.
- Worm SW, Friis-Moller N, Bruyand M, D'Arminio Monforte A, Rickenbach M, Reiss P, El-Sadr W, Phillips A, Lundgren J, Sabin C; D:A:D study group. High prevalence of the metabolic syndrome in HIV-infected patients: impact of different definitions of the metabolic syndrome. AIDS. 2010 Jan 28;24(3):427-35. doi: 10.1097/QAD.0b013e328334344e.
- Worm SW, Sabin C, Weber R, Reiss P, El-Sadr W, Dabis F, De Wit S, Law M, Monforte AD, Friis-Moller N, Kirk O, Fontas E, Weller I, Phillips A, Lundgren J. Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: the data collection on adverse events of anti-HIV drugs (D:A:D) study. J Infect Dis. 2010 Feb 1;201(3):318-30. doi: 10.1086/649897.
- Data Collection on Adverse Events of Anti-HIV drugs (D:A:D) Study Group; Smith C, Sabin CA, Lundgren JD, Thiebaut R, Weber R, Law M, Monforte Ad, Kirk O, Friis-Moller N, Phillips A, Reiss P, El Sadr W, Pradier C, Worm SW. Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D Study. AIDS. 2010 Jun 19;24(10):1537-48. doi: 10.1097/QAD.0b013e32833a0918. Erratum In: AIDS. 2011 Mar 27;25(6):883. multiple author names added.
- Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group; Weber R, Sabin C, Reiss P, de Wit S, Worm SW, Law M, Dabis F, D'Arminio Monforte A, Fontas E, El-Sadr W, Kirk O, Rickenbach M, Phillips A, Ledergerber B, Lundgren J. HBV or HCV coinfections and risk of myocardial infarction in HIV-infected individuals: the D:A:D Cohort Study. Antivir Ther. 2010;15(8):1077-86. doi: 10.3851/IMP1681.
- Peters L, Mocroft A, Soriano V, Rockstroh JK, Losso M, Valerio L, Aldins P, Reiss P, Ledergerber B, Lundgren JD; EuroSIDA Study Group. Hepatitis C virus coinfection does not influence the CD4 cell recovery in HIV-1-infected patients with maximum virologic suppression. J Acquir Immune Defic Syndr. 2009 Apr 15;50(5):457-63. doi: 10.1097/qai.0b013e318198a0e1.
- Cozzi-Lepri A, Phillips AN, Martinez-Picado J, Monforte Ad, Katlama C, Eg Hansen AB, Horban A, Bruun J, Clotet B, Lundgren JD; EuroSIDA Study Group. Rate of accumulation of thymidine analogue mutations in patients continuing to receive virologically failing regimens containing zidovudine or stavudine: implications for antiretroviral therapy programs in resource-limited settings. J Infect Dis. 2009 Sep 1;200(5):687-97. doi: 10.1086/604731.
- Kesselring AM, Wit FW, Sabin CA, Lundgren JD, Gill MJ, Gatell JM, Rauch A, Montaner JS, de Wolf F, Reiss P, Mocroft A; Nevirapine Toxicity Multicohort Collaboration. Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy. AIDS. 2009 Aug 24;23(13):1689-99. doi: 10.1097/QAD.0b013e32832d3b54.
- Worm SW, De Wit S, Weber R, Sabin CA, Reiss P, El-Sadr W, Monforte AD, Kirk O, Fontas E, Dabis F, Law MG, Lundgren JD, Friis-Moller N. Diabetes mellitus, preexisting coronary heart disease, and the risk of subsequent coronary heart disease events in patients infected with human immunodeficiency virus: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D Study). Circulation. 2009 Feb 17;119(6):805-11. doi: 10.1161/CIRCULATIONAHA.108.790857. Epub 2009 Feb 2.
- Worm SW, Sabin CA, Reiss P, El-Sadr W, Monforte Ad, Pradier C, Thiebaut R, Law M, Rickenbach M, De Wit S, Lundgren JD, Friis-Moller N. Presence of the metabolic syndrome is not a better predictor of cardiovascular disease than the sum of its components in HIV-infected individuals: data collection on adverse events of anti-HIV drugs (D:A:D) study. Diabetes Care. 2009 Mar;32(3):474-80. doi: 10.2337/dc08-1394. Epub 2008 Dec 3.
- When To Start Consortium; Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, Harris R, Funk MJ, Geskus RB, Gill J, Dabis F, Miro JM, Justice AC, Ledergerber B, Fatkenheuer G, Hogg RS, Monforte AD, Saag M, Smith C, Staszewski S, Egger M, Cole SR. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009 Apr 18;373(9672):1352-63. doi: 10.1016/S0140-6736(09)60612-7. Epub 2009 Apr 8.
- Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study group; Bohlius J, Schmidlin K, Costagliola D, Fatkenheuer G, May M, Caro Murillo AM, Mocroft A, Bonnet F, Clifford G, Touloumi G, Miro JM, Chene G, Lundgren J, Egger M. Prognosis of HIV-associated non-Hodgkin lymphoma in patients starting combination antiretroviral therapy. AIDS. 2009 Sep 24;23(15):2029-37. doi: 10.1097/QAD.0b013e32832e531c.
- Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Study Group; Bohlius J, Schmidlin K, Costagliola D, Fatkenheuer G, May M, Caro-Murillo AM, Mocroft A, Bonnet F, Clifford G, Karafoulidou A, Miro JM, Lundgren J, Chene G, Egger M. Incidence and risk factors of HIV-related non-Hodgkin's lymphoma in the era of combination antiretroviral therapy: a European multicohort study. Antivir Ther. 2009;14(8):1065-74. doi: 10.3851/IMP1462.
- Podlekareva DN, Mocroft A, Post FA, Riekstina V, Miro JM, Furrer H, Bruyand M, Panteleev AM, Rakhmanova AG, Girardi E, Losso MH, Toibaro JJ, Cayla J, Miller RF, Obel N, Skrahina A, Chentsova N, Lundgren JD, Kirk O; HIV/TB Study Writing Group. Mortality from HIV and TB coinfections is higher in Eastern Europe than in Western Europe and Argentina. AIDS. 2009 Nov 27;23(18):2485-95. doi: 10.1097/QAD.0b013e3283326879.
- antiretroviral therapy cohort collaboration (ART-CC); Lanoy E, May M, Mocroft A, Phillip A, Justice A, Chene G, Furrer H, Sterling T, Monforte AD, Force L, Gill J, Harris R, Hogg RS, Rockstroh J, Saag M, Khaykin P, de Wolf F, Sterne JA, Costagliola D. Prognosis of patients treated with cART from 36 months after initiation, according to current and previous CD4 cell count and plasma HIV-1 RNA measurements. AIDS. 2009 Oct 23;23(16):2199-208. doi: 10.1097/QAD.0b013e3283305a00.
- Moore DM, Harris R, Lima V, Hogg B, May M, Yip B, Justice A, Mocroft A, Reiss P, Lampe F, Chene G, Costagliola D, Elzi L, Mugavero MJ, Monforte AD, Sabin C, Podzamczer D, Fatkenheuer G, Staszewski S, Gill J, Sterne JA; Antiretroviral Therapy Cohort Collaboration. Effect of baseline CD4 cell counts on the clinical significance of short-term immunologic response to antiretroviral therapy in individuals with virologic suppression. J Acquir Immune Defic Syndr. 2009 Nov 1;52(3):357-63. doi: 10.1097/QAI.0b013e3181b62933.
- Antiretroviral Therapy Cohort Collaboration (ART-CC); Mocroft A, Sterne JA, Egger M, May M, Grabar S, Furrer H, Sabin C, Fatkenheuer G, Justice A, Reiss P, d'Arminio Monforte A, Gill J, Hogg R, Bonnet F, Kitahata M, Staszewski S, Casabona J, Harris R, Saag M. Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS-defining conditions are created equal. Clin Infect Dis. 2009 Apr 15;48(8):1138-51. doi: 10.1086/597468.
- Mocroft A, Horban A, Clotet B, d'Arminio Monforte A, Bogner JR, Aldins P, Staub T, Antunes F, Katlama C, Lundgren JD; EuroSIDA Study Group. Regional differences in the risk of triple class failure in European patients starting combination antiretroviral therapy after 1 January 1999. HIV Med. 2008 Jan;9(1):41-6. doi: 10.1111/j.1468-1293.2008.00519.x.
- Mocroft A, Kirk O, Aldins P, Chies A, Blaxhult A, Chentsova N, Vetter N, Dabis F, Gatell J, Lundgren JD; EuroSIDA study group. Loss to follow-up in an international, multicentre observational study. HIV Med. 2008 May;9(5):261-9. doi: 10.1111/j.1468-1293.2008.00557.x.
- D:A:D Study Group; Sabin CA, Worm SW, Weber R, Reiss P, El-Sadr W, Dabis F, De Wit S, Law M, D'Arminio Monforte A, Friis-Moller N, Kirk O, Pradier C, Weller I, Phillips AN, Lundgren JD. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet. 2008 Apr 26;371(9622):1417-26. doi: 10.1016/S0140-6736(08)60423-7. Epub 2008 Apr 2. Erratum In: Lancet. 2008 Jul 26;372(9635):292.
- Deforche K, Cozzi-Lepri A, Theys K, Clotet B, Camacho RJ, Kjaer J, Van Laethem K, Phillips A, Moreau Y, Lundgren JD, Vandamme AM; EuroSIDA Study Group. Modelled in vivo HIV fitness under drug selective pressure and estimated genetic barrier towards resistance are predictive for virological response. Antivir Ther. 2008;13(3):399-407.
- Podlekareva D, Mocroft A, Kirk O, Reiss P, Aldins P, Katlama C, Kovari H, Stellbrink HJ, D'Arminio Monforte A, Lundgren JD; Eurosida Study Group. Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART. Scand J Infect Dis. 2008;40(11-12):908-13. doi: 10.1080/00365540802227094.
- Cozzi-Lepri A, Phillips AN, Clotet B, Mocroft A, Ruiz L, Kirk O, Lazzarin A, Wiercinska-Drapalo A, Karlsson A, Lundgren JD; EuroSIDA Study Group. Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study. AIDS. 2008 Oct 18;22(16):2187-98. doi: 10.1097/QAD.0b013e328310e04f.
- Reekie J, Mocroft A, Sambatakou H, Machala L, Chiesi A, van Lunzen J, Clumeck N, Kirk O, Gazzard B, Lundgren JD; EuroSIDA Study Group. Does less frequent routine monitoring of patients on a stable, fully suppressed cART regimen lead to an increased risk of treatment failure? AIDS. 2008 Nov 12;22(17):2381-90. doi: 10.1097/QAD.0b013e328317a6eb.
- Soriano V, Mocroft A, Rockstroh J, Ledergerber B, Knysz B, Chaplinskas S, Peters L, Karlsson A, Katlama C, Toro C, Kupfer B, Vogel M, Lundgren J; EuroSIDA Study Group. Spontaneous viral clearance, viral load, and genotype distribution of hepatitis C virus (HCV) in HIV-infected patients with anti-HCV antibodies in Europe. J Infect Dis. 2008 Nov 1;198(9):1337-44. doi: 10.1086/592171.
- Antiretroviral Therapy Cohort Collaboration (ART-CC); Mugavero MJ, May M, Harris R, Saag MS, Costagliola D, Egger M, Phillips A, Gunthard HF, Dabis F, Hogg R, de Wolf F, Fatkenheuer G, Gill MJ, Justice A, D'Arminio Monforte A, Lampe F, Miro JM, Staszewski S, Sterne JA. Does short-term virologic failure translate to clinical events in antiretroviral-naive patients initiating antiretroviral therapy in clinical practice? AIDS. 2008 Nov 30;22(18):2481-92. doi: 10.1097/QAD.0b013e328318f130.
- Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008 Jul 26;372(9635):293-9. doi: 10.1016/S0140-6736(08)61113-7.
- Monforte Ad, Abrams D, Pradier C, Weber R, Reiss P, Bonnet F, Kirk O, Law M, De Wit S, Friis-Moller N, Phillips AN, Sabin CA, Lundgren JD; Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group. HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies. AIDS. 2008 Oct 18;22(16):2143-53. doi: 10.1097/QAD.0b013e3283112b77.
- Data Collection on Adverse Events of Anti-HIV Drugs Study Group; Sabin CA, d'Arminio Monforte A, Friis-Moller N, Weber R, El-Sadr WM, Reiss P, Kirk O, Mercie P, Law MG, De Wit S, Pradier C, Phillips AN, Lundgren JD. Changes over time in risk factors for cardiovascular disease and use of lipid-lowering drugs in HIV-infected individuals and impact on myocardial infarction. Clin Infect Dis. 2008 Apr 1;46(7):1101-10. doi: 10.1086/528862.
- Harris RJ, Sterne JA, Abgrall S, Dabis F, Reiss P, Saag M, Phillips AN, Chene G, Gill JM, Justice AC, Rockstroh J, Sabin CA, Mocroft A, Bucher HC, Hogg RS, Monforte AD, May M, Egger M; Antiretroviral Therapy Cohort Collaboration. Prognostic importance of anaemia in HIV type-1-infected patients starting antiretroviral therapy: collaborative analysis of prospective cohort studies. Antivir Ther. 2008;13(8):959-67.
- De Wit S, Sabin CA, Weber R, Worm SW, Reiss P, Cazanave C, El-Sadr W, Monforte Ad, Fontas E, Law MG, Friis-Moller N, Phillips A; Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. Incidence and risk factors for new-onset diabetes in HIV-infected patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. Diabetes Care. 2008 Jun;31(6):1224-9. doi: 10.2337/dc07-2013. Epub 2008 Feb 11.
- Strategies for Management of Anti-Retroviral Therapy/INSIGHT; DAD Study Groups. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients. AIDS. 2008 Sep 12;22(14):F17-24. doi: 10.1097/QAD.0b013e32830fe35e.
- Cozzi-Lepri A, Phillips AN, Ruiz L, Clotet B, Loveday C, Kjaer J, Mens H, Clumeck N, Viksna L, Antunes F, Machala L, Lundgren JD; EuroSIDA Study Group. Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen. AIDS. 2007 Mar 30;21(6):721-32. doi: 10.1097/QAD.0b013e3280141fdf.
- Holkmann Olsen C, Mocroft A, Kirk O, Vella S, Blaxhult A, Clumeck N, Fisher M, Katlama C, Phillips AN, Lundgren JD; EuroSIDA study group. Interruption of combination antiretroviral therapy and risk of clinical disease progression to AIDS or death. HIV Med. 2007 Mar;8(2):96-104. doi: 10.1111/j.1468-1293.2007.00436.x.
- DAD Study Group; Friis-Moller N, Reiss P, Sabin CA, Weber R, Monforte Ad, El-Sadr W, Thiebaut R, De Wit S, Kirk O, Fontas E, Law MG, Phillips A, Lundgren JD. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007 Apr 26;356(17):1723-35. doi: 10.1056/NEJMoa062744.
- Mocroft A, Kirk O, Gatell J, Reiss P, Gargalianos P, Zilmer K, Beniowski M, Viard JP, Staszewski S, Lundgren JD. Chronic renal failure among HIV-1-infected patients. AIDS. 2007 May 31;21(9):1119-27. doi: 10.1097/QAD.0b013e3280f774ee.
- Mocroft A, Phillips AN, Gatell J, Ledergerber B, Fisher M, Clumeck N, Losso M, Lazzarin A, Fatkenheuer G, Lundgren JD; EuroSIDA study group. Normalisation of CD4 counts in patients with HIV-1 infection and maximum virological suppression who are taking combination antiretroviral therapy: an observational cohort study. Lancet. 2007 Aug 4;370(9585):407-13. doi: 10.1016/S0140-6736(07)60948-9.
- Kowalska JD, Mocroft A, Blaxhult A, Colebunders R, van Lunzen J, Podlekareva D, Hansen AB, Machala L, Yust I, Benfield T; EuroSIDA Study Group. Current hemoglobin levels are more predictive of disease progression than hemoglobin measured at baseline in patients receiving antiretroviral treatment for HIV type 1 infection. AIDS Res Hum Retroviruses. 2007 Oct;23(10):1183-8. doi: 10.1089/aid.2006.0292.
- Ceccherini-Silberstein F, Cozzi-Lepri A, Ruiz L, Mocroft A, Phillips AN, Olsen CH, Gatell JM, Gunthard HF, Reiss P, Perno CF, Clotet B, Lundgren JD; EuroSIDA Study Group. Impact of HIV-1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue-based regimens in antiretroviral therapy (ART)-naive and ART-experienced patients. J Infect Dis. 2007 Oct 15;196(8):1180-90. doi: 10.1086/521678. Epub 2007 Sep 19.
- Fox ZV, Geretti AM, Kjaer J, Dragsted UB, Phillips AN, Gerstoft J, Staszewski S, Clotet B, von Wyl V, Lundgren JD. The ability of four genotypic interpretation systems to predict virological response to ritonavir-boosted protease inhibitors. AIDS. 2007 Oct 1;21(15):2033-42. doi: 10.1097/QAD.0b013e32825a69e4.
- Mocroft A, Staszewski S, Weber R, Gatell J, Rockstroh J, Gasiorowski J, Panos G, Monforte Ad, Rakhmanova A, Phillips AN, Lundgren JD; EuroSIDA study group. Risk of discontinuation of nevirapine due to toxicities in antiretroviral-naive and -experienced HIV-infected patients with high and low CD4+ T-cell counts. Antivir Ther. 2007;12(3):325-33. Erratum In: Antivir Ther. 2007;12(4):577.
- Antiretroviral Therapy in Low-Income Countries Collaboration of the International epidemiological Databases to Evaluate AIDS (IeDEA); ART Cohort Collaboration; Brinkhof MW, Egger M, Boulle A, May M, Hosseinipour M, Sprinz E, Braitstein P, Dabis F, Reiss P, Bangsberg DR, Rickenbach M, Miro JM, Myer L, Mocroft A, Nash D, Keiser O, Pascoe M, van der Borght S, Schechter M. Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries. Clin Infect Dis. 2007 Dec 1;45(11):1518-21. doi: 10.1086/522986. Epub 2007 Oct 22.
- Antiretroviral Therapy Cohort Collaboration. Importance of baseline prognostic factors with increasing time since initiation of highly active antiretroviral therapy: collaborative analysis of cohorts of HIV-1-infected patients. J Acquir Immune Defic Syndr. 2007 Dec 15;46(5):607-15. doi: 10.1097/QAI.0b013e31815b7dba.
- May M, Sterne JA, Shipley M, Brunner E, d'Agostino R, Whincup P, Ben-Shlomo Y, Carr A, Ledergerber B, Lundgren JD, Phillips AN, Massaro J, Egger M. A coronary heart disease risk model for predicting the effect of potent antiretroviral therapy in HIV-1 infected men. Int J Epidemiol. 2007 Dec;36(6):1309-18. doi: 10.1093/ije/dym135. Epub 2007 Jul 25.
- Sterne JA, May M, Bucher HC, Ledergerber B, Furrer H, Cavassini M, Bernasconi E, Hirschel B, Egger M; Swiss HIV Cohort. HAART and the heart: changes in coronary risk factors and implications for coronary risk in men starting antiretroviral therapy. J Intern Med. 2007 Mar;261(3):255-67. doi: 10.1111/j.1365-2796.2006.01761.x.
- Llibre JM, Cozzi-Lepri A, La Rosa JA, Pedersen C, Ristola M, Losso M, Mocroft A, Mitsura VM, Ormaasen V, Maltez F, Beniowski M, Paredes R; Eurosida in Eurocoord. Long term effectiveness of once-daily unboosted atazanavir plus abacavir/lamivudine as a switch strategy in subjects with virological suppression. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19810. doi: 10.7448/IAS.17.4.19810. eCollection 2014.
- Schultze A, Paredes R, Sabin C, Phillips AN, Pillay D, Kirk O, Lundgren JD, Pozniak A, Nelson M, Cozzi-Lepri A; Eurosida in Eurocoord. Detection of resistance mutations and CD4 slopes in individuals experiencing sustained virological failure. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19737. doi: 10.7448/IAS.17.4.19737. eCollection 2014.
- Fontdevila MC, Cozzi-Lepri A, Phillips A, Julian MN, Bickel M, Sedlacek D, Kronborg G, Lazzarin A, Zilmer K, Clotet B, Lundgren JD, Paredes R. Plasma HIV-1 tropism and risk of short-term clinical progression to AIDS or death. J Int AIDS Soc. 2014 Nov 2;17(4 Suppl 3):19685. doi: 10.7448/IAS.17.4.19685. eCollection 2014.
- Mocroft A, Reiss P, Gasiorowski J, Ledergerber B, Kowalska J, Chiesi A, Gatell J, Rakhmanova A, Johnson M, Kirk O, Lundgren J; EuroSIDA Study Group. Serious fatal and nonfatal non-AIDS-defining illnesses in Europe. J Acquir Immune Defic Syndr. 2010 Oct;55(2):262-70. doi: 10.1097/QAI.0b013e3181e9be6b.
- Young J, Bucher HC, Guenthard HF, Rickenbach M, Fux CA, Hirschel B, Cavassini M, Vernazza P, Bernasconi E, Battegay M; Swiss HIV Cohort Study. Virological and immunological responses to efavirenz or boosted lopinavir as first-line therapy for patients with HIV. Antivir Ther. 2009;14(6):771-9. doi: 10.3851/IMP1291.
- Smith CJ, Mocroft A, Lundgren JD; EuroSIDA Study Group. Incidence of pancreatitis in HIV-infected patients, and the association with antiretroviral therapy. AIDS. 2008 May 11;22(8):997-8. doi: 10.1097/QAD.0b013e3282ffb0fd. No abstract available.
- Bannister WP, Ruiz L, Loveday C, Vella S, Zilmer K, Kjaer J, Knysz B, Phillips AN, Mocroft A; EuroSIDA Study Group. HIV-1 subtypes and response to combination antiretroviral therapy in Europe. Antivir Ther. 2006;11(6):707-15.
- Mocroft, Horban, Clumeck, Stellbrink, Monforte dA, Zilmer, Kirk, Gatell, Phillips, Lundgren; EuroSIDA Study Group. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naive patients starting cART after January 1, 2000. HIV Clin Trials. 2006 Nov-Dec;7(6):271-84. doi: 10.1310/hct0706-271.
- Mocroft A, Rockstroh J, Soriano V, Kirk O, Viard JP, Caplinskas S, Gasiorowski J, Chiesi A, Phillips AN, Lundgren JD; EuroSIDA Study Group. Limited but increasing use of treatment for hepatitis C across Europe in patients coinfected with HIV and hepatitis C. Scand J Infect Dis. 2006;38(11-12):1092-7. doi: 10.1080/00365540600786515.
- Mocroft A, Neaton J, Bebchuk J, Staszewski S, Antunes F, Knysz B, Law M, Phillips AN, Lundgren JD; EuroSIDA Study Group; ESPRIT Study Group. The feasibility of clinical endpoint trials in HIV infection in the highly active antiretroviral treatment (HAART) era. Clin Trials. 2006;3(2):119-32. doi: 10.1191/1740774506cn138oa.
- Bannister WP, Kirk O, Gatell JM, Knysz B, Viard JP, Mens H, Monforte AD, Phillips AN, Mocroft A, Lundgren JD; EuroSIDA Study Group. Regional changes over time in initial virologic response rates to combination antiretroviral therapy across Europe. J Acquir Immune Defic Syndr. 2006 Jun;42(2):229-37. doi: 10.1097/01.qai.0000214815.95786.31.
- Rockstroh JK. Influence of viral hepatitis on HIV infection. J Hepatol. 2006;44(1 Suppl):S25-7. doi: 10.1016/j.jhep.2005.11.007. Epub 2005 Nov 21.
- Braitstein P, Brinkhof MW, Dabis F, Schechter M, Boulle A, Miotti P, Wood R, Laurent C, Sprinz E, Seyler C, Bangsberg DR, Balestre E, Sterne JA, May M, Egger M; Antiretroviral Therapy in Lower Income Countries (ART-LINC) Collaboration; ART Cohort Collaboration (ART-CC) groups. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet. 2006 Mar 11;367(9513):817-24. doi: 10.1016/S0140-6736(06)68337-2. Erratum In: Lancet. 2006 Jun 10;367(9526):1902.
- Law MG, Friis-Moller N, El-Sadr WM, Weber R, Reiss P, D'Arminio Monforte A, Thiebaut R, Morfeldt L, De Wit S, Pradier C, Calvo G, Kirk O, Sabin CA, Phillips AN, Lundgren JD; D:A:D Study Group. The use of the Framingham equation to predict myocardial infarctions in HIV-infected patients: comparison with observed events in the D:A:D Study. HIV Med. 2006 May;7(4):218-30. doi: 10.1111/j.1468-1293.2006.00362.x.
- Mocroft A, Phillips AN, Ledergerber B, Katlama C, Chiesi A, Goebel FD, Knysz B, Antunes F, Reiss P, Lundgren JD. Relationship between antiretrovirals used as part of a cART regimen and CD4 cell count increases in patients with suppressed viremia. AIDS. 2006 May 12;20(8):1141-50. doi: 10.1097/01.aids.0000226954.95094.39.
- Weber R, Sabin CA, Friis-Moller N, Reiss P, El-Sadr WM, Kirk O, Dabis F, Law MG, Pradier C, De Wit S, Akerlund B, Calvo G, Monforte Ad, Rickenbach M, Ledergerber B, Phillips AN, Lundgren JD. Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med. 2006 Aug 14-28;166(15):1632-41. doi: 10.1001/archinte.166.15.1632.
- Puoti M, Cozzi-Lepri A, Paraninfo G, Arici C, Moller NF, Lundgren JD, Ledergerber B, Rickenbach M, Suarez-Lozano I, Garrido M, Dabis F, Winnock M, Milazzo L, Gervais A, Raffi F, Gill J, Rockstroh J, Ourishi N, Mussini C, Castagna A, De Luca A, Monforte Ad; HBV-HIV International Intercohort Study Group. Impact of lamivudine on the risk of liver-related death in 2,041 HBsAg- and HIV-positive individuals: results from an inter-cohort analysis. Antivir Ther. 2006;11(5):567-74. doi: 10.1177/135965350601100509. Erratum In: Antivir Ther. 2006;11(6):831. Paraninfo, Giuseppe [added].
- May MT, Sterne JA, Costagliola D, Sabin CA, Phillips AN, Justice AC, Dabis F, Gill J, Lundgren J, Hogg RS, de Wolf F, Fatkenheuer G, Staszewski S, d'Arminio Monforte A, Egger M; Antiretroviral Therapy (ART) Cohort Collaboration. HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis. Lancet. 2006 Aug 5;368(9534):451-8. doi: 10.1016/S0140-6736(06)69152-6.
- Antiretroviral Therapy Cohort Collaboration. Rates of disease progression according to initial highly active antiretroviral therapy regimen: a collaborative analysis of 12 prospective cohort studies. J Infect Dis. 2006 Sep 1;194(5):612-22. doi: 10.1086/506362. Epub 2006 Jul 31.
- Cozzi-Lepri A, Ruiz L, Loveday C, Phillips AN, Clotet B, Reiss P, Ledergerber B, Holkmann C, Staszewski S, Lundgren JD; EuroSIDA Study Group. Thymidine analogue mutation profiles: factors associated with acquiring specific profiles and their impact on the virological response to therapy. Antivir Ther. 2005;10(7):791-802.
- Mocroft A, Rockstroh J, Soriano V, Ledergerber B, Kirk O, Vinogradova E, Reiss P, Katlama C, Phillips AN, Lundgren JD; EuroSIDA Study Group. Are specific antiretrovirals associated with an increased risk of discontinuation due to toxicities or patient/physician choice in patients with hepatitis C virus coinfection? Antivir Ther. 2005;10(7):779-90.
- Mocroft A, Soriano V, Rockstroh J, Reiss P, Kirk O, de Wit S, Gatell J, Clotet B, Phillips AN, Lundgren JD; EuroSIDA Study Group. Is there evidence for an increase in the death rate from liver-related disease in patients with HIV? AIDS. 2005 Dec 2;19(18):2117-25. doi: 10.1097/01.aids.0000194799.43799.ea.
- Mocroft A, Phillips AN, Soriano V, Rockstroh J, Blaxhult A, Katlama C, Boron-Kaczmarska A, Viksna L, Kirk O, Lundgren JD; EuroSIDA Study Group. Reasons for stopping antiretrovirals used in an initial highly active antiretroviral regimen: increased incidence of stopping due to toxicity or patient/physician choice in patients with hepatitis C coinfection. AIDS Res Hum Retroviruses. 2005 Sep;21(9):743-52. doi: 10.1089/aid.2005.21.743.
- Rockstroh JK, Mocroft A, Soriano V, Tural C, Losso MH, Horban A, Kirk O, Phillips A, Ledergerber B, Lundgren J; EuroSIDA Study Group. Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis. 2005 Sep 15;192(6):992-1002. doi: 10.1086/432762. Epub 2005 Aug 11.
- Mocroft A, Phillips AN, Soriano V, Rockstroh J, Blaxhult A, Katlama C, Boron-Kaczmarska A, Viksna L, Kirk O, Lundgren JD; EuroSIDA Study Group. Reasons for stopping antiretrovirals used in an initial highly active antiretroviral regimen: increased incidence of stopping due to toxicity or patient/physician choice in patients with hepatitis C coinfection. AIDS Res Hum Retroviruses. 2005 Jun;21(6):527-36. doi: 10.1089/aid.2005.21.527.
- Mocroft A, Oancea C, van Lunzen J, Vanhems P, Banhegyi D, Chiesi A, Vinogradova E, Maayan S, Phillips AN, Lundgren J; EuroSIDA study group. Decline in esophageal candidiasis and use of antimycotics in European patients with HIV. Am J Gastroenterol. 2005 Jul;100(7):1446-54. doi: 10.1111/j.1572-0241.2005.41949.x.
- Olsen CH, Gatell J, Ledergerber B, Katlama C, Friis-Moller N, Weber J, Horban A, Staszewski S, Lundgren JD, Phillips AN; EuroSIDA Study Group. Risk of AIDS and death at given HIV-RNA and CD4 cell count, in relation to specific antiretroviral drugs in the regimen. AIDS. 2005 Feb 18;19(3):319-30.
- Mocroft A, Gatell J, Reiss P, Ledergerber B, Kirk O, Vella S, Blaxhult A, Phillips AN, Lundgren J; EuroSIDA study group. Causes of death in HIV infection: the key determinant to define the clinical response to anti-HIV therapy. AIDS. 2004 Nov 19;18(17):2333-7. doi: 10.1097/00002030-200411190-00018.
- Phillips AN, Ledergerber B, Horban A, Reiss P, Chiesi A, Kirk O, Mulchany F, Fisher M, Machala L, Lundgren JD; EuroSIDA Study Group. Rate of viral rebound according to specific drugs in the regimen in 2120 patients with HIV suppression. AIDS. 2004 Sep 3;18(13):1795-804. doi: 10.1097/00002030-200409030-00008.
- Lundgren JD, Mocroft A. Anemia and survival in human immunodeficiency virus. Clin Infect Dis. 2003;37 Suppl 4:S297-303. doi: 10.1086/376909.
- Mocroft A, Ruiz L, Reiss P, Ledergerber B, Katlama C, Lazzarin A, Goebel FD, Phillips AN, Clotet B, Lundgren JD; EuroSIDA study group. Virological rebound after suppression on highly active antiretroviral therapy. AIDS. 2003 Aug 15;17(12):1741-51. doi: 10.1097/00002030-200308150-00003.
- Cozzi-Lepri A, Phillips AN, Miller V, Katlama C, Ledergerber B, Vella S, Weber J, Bruun JN, Kirk O, Clotet B, Lundgrens JD. Changes in viral load in people with virological failure who remain on the same HAART regimen. Antivir Ther. 2003 Apr;8(2):127-36.
- Moore AL, Kirk O, Johnson AM, Katlama C, Blaxhult A, Dietrich M, Colebunders R, Chiesi A, Lungren JD, Phillips AN; EuroSIDA group. Virologic, immunologic, and clinical response to highly active antiretroviral therapy: the gender issue revisited. J Acquir Immune Defic Syndr. 2003 Apr 1;32(4):452-61. doi: 10.1097/00126334-200304010-00017.
- Blaxhult A, Fox Z, Colebunders R, Francioli P, Ben-Ishai Z, Fatkenheuer G, Parkin JM, Vanhems P, Phillips AN, Kirk O; EuroSIDA Study Group. Regional and temporal changes in AIDS in Europe before HAART. Epidemiol Infect. 2002 Dec;129(3):565-76. doi: 10.1017/s0950268802007719.
- Kirk O, Pedersen C, Law M, Gulick RM, Moyle G, Montaner J, Eron JJ Jr, Phillips AN, Lundgren JD. Analysis of virological efficacy in trials of antiretroviral regimens: drawbacks of not including viral load measurements after premature discontinuation of therapy. Antivir Ther. 2002 Dec;7(4):271-81.
- Kirk O, Reiss P, Uberti-Foppa C, Bickel M, Gerstoft J, Pradier C, Wit FW, Ledergerber B, Lundgren JD, Furrer H; European HIV Cohorts. Safe interruption of maintenance therapy against previous infection with four common HIV-associated opportunistic pathogens during potent antiretroviral therapy. Ann Intern Med. 2002 Aug 20;137(4):239-50. doi: 10.7326/0003-4819-137-4-200208200-00008.
- Phillips AN, Pradier C, Lazzarin A, Clotet B, Goebel FD, Hermans P, Antunes F, Ledergerber B, Kirk O, Lundgren JD; EuroSIDA Study Group. Viral load outcome of non-nucleoside reverse transcriptase inhibitor regimens for 2203 mainly antiretroviral-experienced patients. AIDS. 2001 Dec 7;15(18):2385-95. doi: 10.1097/00002030-200112070-00006.
- Phillips AN, Staszewski S, Weber R, Kirk O, Francioli P, Miller V, Vernazza P, Lundgren JD, Ledergerber B; Swiss HIV Cohort Study; Frakfurt HIV Clinic Cohort; EuroSIDA Study Group. HIV viral load response to antiretroviral therapy according to the baseline CD4 cell count and viral load. JAMA. 2001 Nov 28;286(20):2560-7. doi: 10.1001/jama.286.20.2560.
- Kirk O, Pedersen C, Cozzi-Lepri A, Antunes F, Miller V, Gatell JM, Katlama C, Lazzarin A, Skinhoj P, Barton SE; EuroSIDA Study Group. Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy. Blood. 2001 Dec 1;98(12):3406-12. doi: 10.1182/blood.v98.12.3406.
- Kirk O, Mocroft A, Pradier C, Bruun JN, Hemmer R, Clotet B, Miller V, Viard JP, Phillips AN, Lundgren JD; EuroSIDA Study Group. Clinical outcome among HIV-infected patients starting saquinavir hard gel compared to ritonavir or indinavir. AIDS. 2001 May 25;15(8):999-1008. doi: 10.1097/00002030-200105250-00008.
- Norton M. Stopping PCP prophylaxis after suppressing HIV. GMHC Treat Issues. 1999 Apr;13(4):4-5.
- Thiebaut R, El-Sadr WM, Friis-Moller N, Rickenbach M, Reiss P, Monforte AD, Morfeldt L, Fontas E, Kirk O, De Wit S, Calvo G, Law MG, Dabis F, Sabin CA, Lundgren JD; Data Collection of Adverse events of anti-HIV Drugs Study Group. Predictors of hypertension and changes of blood pressure in HIV-infected patients. Antivir Ther. 2005;10(7):811-23. doi: 10.1177/135965350501000706. Erratum In: Antivir Ther. 2005;10(8):969.
- Girardi E, Sabin CA, d'Arminio Monforte A, Hogg B, Phillips AN, Gill MJ, Dabis F, Reiss P, Kirk O, Bernasconi E, Grabar S, Justice A, Staszewski S, Fatkenheuer G, Sterne JA; Antiretroviral Therapy Cohort Collaboration. Incidence of Tuberculosis among HIV-infected patients receiving highly active antiretroviral therapy in Europe and North America. Clin Infect Dis. 2005 Dec 15;41(12):1772-82. doi: 10.1086/498315. Epub 2005 Nov 11.
- Sabine C; Antiretroviral Therapy (ART) Cohort Collaboration. AIDS events among individuals initiating HAART: do some patients experience a greater benefit from HAART than others? AIDS. 2005 Nov 18;19(17):1995-2000. doi: 10.1097/01.aids.0000189858.59559.d2.
- May M, Porter K, Sterne JA, Royston P, Egger M. Prognostic model for HIV-1 disease progression in patients starting antiretroviral therapy was validated using independent data. J Clin Epidemiol. 2005 Oct;58(10):1033-41. doi: 10.1016/j.jclinepi.2005.02.015.
- d'Arminio Monforte A, Sabin CA, Phillips A, Sterne J, May M, Justice A, Dabis F, Grabar S, Ledergerber B, Gill J, Reiss P, Egger M; Antiretroviral Therapy Cohort Collaboration. The changing incidence of AIDS events in patients receiving highly active antiretroviral therapy. Arch Intern Med. 2005 Feb 28;165(4):416-23. doi: 10.1001/archinte.165.4.416. Erratum In: Arch Intern Med. 2005 May 23;165(10):1200.
- Fontas E, van Leth F, Sabin CA, Friis-Moller N, Rickenbach M, d'Arminio Monforte A, Kirk O, Dupon M, Morfeldt L, Mateu S, Petoumenos K, El-Sadr W, de Wit S, Lundgren JD, Pradier C, Reiss P; D:A:D Study Group. Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles? J Infect Dis. 2004 Mar 15;189(6):1056-74. doi: 10.1086/381783. Epub 2004 Mar 2.
- Ledergerber B, Lundgren JD, Walker AS, Sabin C, Justice A, Reiss P, Mussini C, Wit F, d'Arminio Monforte A, Weber R, Fusco G, Staszewski S, Law M, Hogg R, Lampe F, Gill MJ, Castelli F, Phillips AN; PLATO Collaboration. Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes. Lancet. 2004 Jul 3-9;364(9428):51-62. doi: 10.1016/S0140-6736(04)16589-6.
- d'Arminio A, Sabin CA, Phillips AN, Reiss P, Weber R, Kirk O, El-Sadr W, De Wit S, Mateu S, Petoumenos K, Dabis F, Pradier C, Morfeldt L, Lundgren JD, Friis-Moller N; Writing Committee of the D:A:D: Study Group. Cardio- and cerebrovascular events in HIV-infected persons. AIDS. 2004 Sep 3;18(13):1811-7. doi: 10.1097/00002030-200409030-00010.
- Collaboration of HIV Cohorts. Nucleoside analogue use before and during highly active antiretroviral therapy and virus load rebound. J Infect Dis. 2004 Aug 15;190(4):675-87. doi: 10.1086/421707. Epub 2004 Jul 19.
- Law M, Friis-Moller N, Weber R, Reiss P, Thiebaut R, Kirk O, d'Arminio Monforte A, Pradier C, Morfeldt L, Calvo G, El-Sadr W, De Wit S, Sabin CA, Lundgren JD; DAD Study Group. Modelling the 3-year risk of myocardial infarction among participants in the Data Collection on Adverse Events of Anti-HIV Drugs (DAD) study. HIV Med. 2003 Jan;4(1):1-10. doi: 10.1046/j.1468-1293.2003.00138.x.
- May M, Royston P, Egger M, Justice AC, Sterne JA; ART Cohort Collaboration. Development and validation of a prognostic model for survival time data: application to prognosis of HIV positive patients treated with antiretroviral therapy. Stat Med. 2004 Aug 15;23(15):2375-98. doi: 10.1002/sim.1825.
- Friis-Moller N, Weber R, Reiss P, Thiebaut R, Kirk O, d'Arminio Monforte A, Pradier C, Morfeldt L, Mateu S, Law M, El-Sadr W, De Wit S, Sabin CA, Phillips AN, Lundgren JD; DAD study group. Cardiovascular disease risk factors in HIV patients--association with antiretroviral therapy. Results from the DAD study. AIDS. 2003 May 23;17(8):1179-93. doi: 10.1097/01.aids.0000060358.78202.c1.
- Chene G, Sterne JA, May M, Costagliola D, Ledergerber B, Phillips AN, Dabis F, Lundgren J, D'Arminio Monforte A, de Wolf F, Hogg R, Reiss P, Justice A, Leport C, Staszewski S, Gill J, Fatkenheuer G, Egger ME; Antiretroviral Therapy Cohort Collaboration. Prognostic importance of initial response in HIV-1 infected patients starting potent antiretroviral therapy: analysis of prospective studies. Lancet. 2003 Aug 30;362(9385):679-86. doi: 10.1016/s0140-6736(03)14229-8.
- Friis-Moller N, Sabin CA, Weber R, d'Arminio Monforte A, El-Sadr WM, Reiss P, Thiebaut R, Morfeldt L, De Wit S, Pradier C, Calvo G, Law MG, Kirk O, Phillips AN, Lundgren JD; Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med. 2003 Nov 20;349(21):1993-2003. doi: 10.1056/NEJMoa030218. Erratum In: N Engl J Med. 2004 Feb 26;350(9):955.
- Miller V, Phillips AN, Clotet B, Mocroft A, Ledergerber B, Kirk O, Ormaasen V, Gargalianos-Kakolyris P, Vella S, Lundgren JD. Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts. J Infect Dis. 2002 Jul 15;186(2):189-97. doi: 10.1086/341466. Epub 2002 Jul 3.
- Egger M, May M, Chene G, Phillips AN, Ledergerber B, Dabis F, Costagliola D, D'Arminio Monforte A, de Wolf F, Reiss P, Lundgren JD, Justice AC, Staszewski S, Leport C, Hogg RS, Sabin CA, Gill MJ, Salzberger B, Sterne JA; ART Cohort Collaboration. Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet. 2002 Jul 13;360(9327):119-29. doi: 10.1016/s0140-6736(02)09411-4. Erratum In: Lancet 2002 Oct 12;360(9340):1178.
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Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. januar 1994
Primær fullføring (Antatt)
1. desember 2030
Studiet fullført (Antatt)
1. desember 2030
Datoer for studieregistrering
Først innsendt
19. januar 2016
Først innsendt som oppfylte QC-kriteriene
29. februar 2016
Først lagt ut (Antatt)
4. mars 2016
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
12. april 2024
Siste oppdatering sendt inn som oppfylte QC-kriteriene
10. april 2024
Sist bekreftet
1. april 2024
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
- Sykdommer i fordøyelsessystemet
- Leversvikt
- Leverinsuffisiens
- Patologiske prosesser
- Metabolske sykdommer
- RNA-virusinfeksjoner
- Virussykdommer
- Infeksjoner
- Blodbårne infeksjoner
- Smittsomme sykdommer
- Nyresykdommer
- Urologiske sykdommer
- Urologiske manifestasjoner
- Sår og skader
- Sykdomsattributter
- Vannlatingsforstyrrelser
- Flaviviridae-infeksjoner
- Hepatitt, viral, menneskelig
- Hepadnaviridae-infeksjoner
- DNA-virusinfeksjoner
- Enterovirusinfeksjoner
- Picornaviridae-infeksjoner
- Nyresvikt, kronisk
- Syre-base ubalanse
- Kronisk sykdom
- Kvinnelige urogenitale sykdommer
- Kvinnelige urogenitale sykdommer og graviditetskomplikasjoner
- Urogenitale sykdommer
- Mannlige urogenitale sykdommer
- Leversykdommer
- Sluttstadium leversykdom
- Kardiovaskulære sykdommer
- Hepatitt B
- Hepatitt
- Hepatitt A-virus
- Hepatitt C
- Nyresvikt, kronisk
- Proteinuri
- Nyreinsuffisiens
- Brudd, bein
- Saminfeksjon
- Acidose
- Acidose, melkesyre
Andre studie-ID-numre
- The EuroSIDA Study
- QLK2-2000-00773 (Annet stipend/finansieringsnummer: EC FP5 1998-2002)
- LSHC-CT-2006-018632 (Annet stipend/finansieringsnummer: EC FP6 2002-2006)
- Gilead EuroSIDA (Annet stipend/finansieringsnummer: Gilead)
- GSK EuroSIDA (Annet stipend/finansieringsnummer: GlaxoSmithKline)
- Janssen EuroSIDA (Annet stipend/finansieringsnummer: Janssen)
- CT94-1637 (Annet stipend/finansieringsnummer: EC BIOMED 1)
- CT97-2713 (Annet stipend/finansieringsnummer: EC BIOMED 2)
- Pfizer EuroSIDA (Annet stipend/finansieringsnummer: Pfizer)
- Merck EuroSIDA (Annet stipend/finansieringsnummer: Merck and Co)
- BMS EuroSIDA (Annet stipend/finansieringsnummer: Bristol-Myers Squibb)
- SNSF 108787 (Annet stipend/finansieringsnummer: The Swiss National Science Foundation)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
NEI
Studiedata/dokumenter
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