Long-term Study in Patients Under Anti-retroviral Combination Therapy Switching to Viramune®

Inclusion Criteria:

• Adult male and female out-patients with HIV type 1 infection who have achieved a viral load below detection limit (50 copies/ml) for more than 6 months under a previous combination therapy with protease-inhibitors (PI) or non-nucleoside reverse transcriptase inhibitors (NNRTI)
• Women can only be included, if a test has excluded pregnancy
• Only women can be included, who use a reliable means of contraception during the observational study

Exclusion Criteria:

• Known sensitivity to Viramune or one of its excipients
• Clinically relevant changes in lab findings (e.g. increase in aspartate aminotransferase (AST) or alanine aminotransferase (ALT) by more than five-fold of upper limit normal)
• Patient is not able to abstain from treatment with ketoconazole, oral contraceptives, and other medication CYP3A metabolism

• For females:

  • Pregnancy
  • Breast-feeding
  • Insufficient or unreliable contraception