- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00417183
Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation
Randomized Controlled Trial Comparing the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation in Normal Responders
Study Overview
Status
Conditions
Detailed Description
The formulation of controlled ovarian stimulation protocols is one of the primary reasons for the successful development of IVF. The "long" GnRH agonist protocol, also known as the gold standard, has been widely used with considerable success. More recently, on the other hand, GnRH antagonist provide a new promising approach for endogenous gonadotrophin suppression by blocking the GnRH receptor. There is conflicting data in the literature regarding the relative merits of the two ovarian stimulation protocols.
COMPARISON: Pregnancy rates and embryological data will by assessed in IVF patients treated with either the "long" GnRH agonist (Arvekap) or the flexible GnRH antagonist (Ganirelix) protocol.
Study Type
Enrollment
Phase
- Phase 4
Contacts and Locations
Study Contact
- Name: Tryfon Lainas, PhD
- Phone Number: 00302107236333
- Email: ivf@eugonia.com.gr
Study Locations
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-
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Athens, Greece, 11528
- Recruiting
- Eugonia
-
Contact:
- Tryfon Lainas, PhD
- Phone Number: 00302107236333
- Email: ivf@eugonia.com.gr
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Age 18-39 years
- Body mass index 18-29 kg/m2
- Menstrual cycle from 24-35 days
- Normal basal FSH (<10 IU/ml)
- Normal basal LH (<10 IU/ml)
- Normal basal estradiol (<80 pg/ml)
Exclusion Criteria:
- Poor responder patients
- Polycystic ovaries
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Ongoing pregnancy per embryo transfer
|
Secondary Outcome Measures
Outcome Measure |
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Biochemical pregnancy per embryo transfer
|
Clinical pregnancy per embryo transfer
|
Embryological data
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Infertility
- Physiological Effects of Drugs
- Antineoplastic Agents
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Antineoplastic Agents, Hormonal
- Hormone Antagonists
- Contraceptive Agents, Hormonal
- Contraceptive Agents
- Reproductive Control Agents
- Contraceptive Agents, Female
- Luteolytic Agents
- Triptorelin Pamoate
- Ganirelix
Other Study ID Numbers
- long vs flexible
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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