Risk Factors for Endometrial Cancer in Black Women

Endometrial Cancer in Black Women

RATIONALE: Learning about the risk factors for endometrial cancer in black women may help the study of endometrial cancer in the future.

PURPOSE: This clinical trial is studying risk factors for endometrial cancer in black women.

Study Overview

• Status: Active, not recruiting
• Conditions: Endometrial Cancer
• Intervention / Treatment: Other: questionnaire administration; Procedure: evaluation of cancer risk factors; Other: study of socioeconomic and demographic variables

Detailed Description

OBJECTIVES:

• Establish and evaluate procedures for conducting a hospital-based case-control study of risk factors for endometrial cancer in black women.

OUTLINE: This is a multicenter study.

Participants complete questionnaires about lifestyle factors and their usual diet and measure their waist and hips. Saliva or buccal specimens are collected for future research.

PROJECTED ACCRUAL:

• A total of 30 cases and 30 controls will be accrued for this study.

• Study Type: Observational
• Enrollment (Actual): 59

Contacts and Locations

Study Locations

• United States
  • New York
    • Brooklyn, New York, United States, 11203
      • SUNY Downstate Medical Center
    • New York, New York, United States, 10065
      • Memorial Sloan Kettering Cancer Center
    • New York, New York, United States, 10031
      • City College of New York
    • The Bronx, New York, United States, 10461
      • Montefiore Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Black women (including African-American, African, Afro-Caribbean women) with endometrial cancer and controls will be recruited at MSKCC, SUNY Downstate Medical Center and Montefiore Medical Center hospitals. Controls will be black (including African-American, African, Afro-Caribbean) women without history of cancer, who have intact uteri, and will be identified in gynecology clinics. Controls will also be recruited at the Breast Examination Center of Harlem (BECH), an affiliate of MSKCC, providing high quality screening services to a minority community.

Description

DISEASE CHARACTERISTICS:

• Cases

  • Diagnosed with endometrial cancer within the past year
  • Self-identified as being black, African-American, black Hispanic, African, or Afro-Caribbean

• Healthy controls

  • Self-identified as being black, African-American, black Hispanic, African, or Afro-Caribbean
  • No history of endometrial or other cancer (except non-melanoma skin cancer)
  • No prior hysterectomy

PATIENT CHARACTERISTICS:

• Speak English
• No medical condition that would make it difficult to complete the interview

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
case; Participants complete questionnaires about lifestyle factors and their usual diet and measure their waist and hips. Saliva or buccal specimens are collected for future research.	Other: questionnaire administration; Procedure: evaluation of cancer risk factors; Other: study of socioeconomic and demographic variables
control; Participants complete questionnaires about lifestyle factors and their usual diet and measure their waist and hips. Saliva or buccal specimens are collected for future research.	Other: questionnaire administration; Procedure: evaluation of cancer risk factors; Other: study of socioeconomic and demographic variables

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Number and percentage of potential cases and controls approached who are found to be eligible for the study and reasons for being ineligible (including language)	2 years
Number and percentage of cases and controls approached who sign informed consent	2 years
Number and percentage of cases and controls who complete each part of the study (main questionnaire, diet questionnaire, saliva/buccal specimen)	2 years
Proportion of questions with missing data	2 years
Interviewer's evaluation of interview quality and respondent cooperation	2 years
Number and percentage of cases who are willing to have tumor specimens used for future research	2 years
Characteristics of cases and controls (demographics, main risk factors, and use of health care and screening)	2 years
Proportion of participants who rate the study positively on each measure in the post-interview assessment and respondents' suggested changes to the study	2 years

Collaborators and Investigators

• Sponsor: Memorial Sloan Kettering Cancer Center
• Collaborators: National Cancer Institute (NCI); Montefiore Medical Center; The City College of New York; DOWNSTATE MED/KINGS CO/BKLYN
• Investigators: Principal Investigator: Sara Olson, PhD, Memorial Sloan Kettering Cancer Center

Publications and helpful links

Helpful Links

• Memorial Sloan Kettering Cancer Center

Study record dates

Study Major Dates

• Study Start: July 1, 2007
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): July 1, 2027

Study Registration Dates

• First Submitted: August 8, 2007
• First Submitted That Met QC Criteria: August 8, 2007
• First Posted (Estimated): August 9, 2007

Study Record Updates

• Last Update Posted (Actual): August 13, 2026
• Last Update Submitted That Met QC Criteria: August 11, 2026
• Last Verified: August 1, 2026

More Information

Terms related to this study

• Keywords: endometrial cancer; risk factors; questionnaire; 07-093
• Additional Relevant MeSH Terms: Urogenital Diseases; Genital Diseases; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Uterine Diseases; Genital Diseases, Female; Genital Neoplasms, Female; Uterine Neoplasms; Endometrial Neoplasms
• Other Study ID Numbers: 07-093; P30CA008748 (U.S. NIH Grant/Contract); MSKCC-07093