Heart Valve Prosthesis-Patient Mismatch

May 9, 2008 updated by: Florence Nightingale Hospital, Istanbul

Impact of Prosthesis-Patient Mismatch on Clinical Outcomes After Mitral Valve Replacement

The purpose of this study is to determine the frequency of prosthesis-patient mismatch after mitral valve replacement and its effect on clinical outcomes.

Study Overview

Status

Completed

Conditions

Detailed Description

Mitral valve replacement (MVR) is associated with higher short and long term mortality than aortic valve replacement or mitral valve repair. The suboptimal results of MVR underline the importance of identifying and preventing prosthesis- patient mismatch. The effective orifice area (EOA) of prosthetic valves used for MVR is often too small in relation to body size, thus causing a mismatch between valve EOA and transvalvular flow. As a consequence, normally functioning mitral prostheses often have relatively high gradients that are similar to those found in patients with mild to moderate mitral stenosis. Residual pressure gradients across mitral prostheses delay the regression of left atrial and pulmonary arterial hypertension. Pulmonary hypertension may cause rightsided failure and is an important risk factor for morbidity and mortality in patients with cardiovascular diseases. However data about the frequency of prosthesis-patient mismatch after mitral valve replacement and its effect on clinical outcome is inconclusive. Predetermined outcomes will be evaluated in the clinical course of this condition.

Study Type

Observational

Enrollment (Anticipated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
    • Sisli
      • Istanbul, Sisli, Turkey, 34381
        • T.C. Bilim University, Medical Faculty, Florence Nightingale Hospital, Division of Cardiology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Tertiary care clinic

Description

Inclusion Criteria:

  • Patients > 18 years with a clinical condition of mitral valve prosthesis

Exclusion Criteria:

  • Evidence of prosthesis valve dysfunction (dehisence, endocarditis or thrombus of prosthetic mitral valve)
  • Concomitant aortic valve prosthesis and tricuspid valve prosthesis
  • Presence of > +2 aortic valve regurgitation and/or mild aortic stenosis
  • Prosthetic mitral valve replacement operation < 6 months
  • Left ventricular ejection fraction < 50%
  • Chronic obstructive pulmonary disease
  • Concomitant hypertrophic cardiomyopathy, atrial septal defect
  • Patients with poor ehocardiographic window

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Only
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
A1
Patients with prosthesis-patient mismatch after mitral valve replacement
A2
Patients without prosthesis mismatch after mitral valve replacement

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Florence Nightingale Hospital, Istanbul

Investigators

  • Principal Investigator: Saide Aytekin, Professor, T.C. Istanbul Bilim University, Medical Faculty, Florence Nightingale Hospital, Division of Cardiology

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2008

Primary Completion (Actual)

May 1, 2008

Study Completion (Actual)

May 1, 2008

Study Registration Dates

First Submitted

February 27, 2008

First Submitted That Met QC Criteria

March 5, 2008

First Posted (Estimate)

March 6, 2008

Study Record Updates

Last Update Posted (Estimate)

May 12, 2008

Last Update Submitted That Met QC Criteria

May 9, 2008

Last Verified

May 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AT-1974

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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