- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01104909
How to Get a Better Dry Weight in End-stage Renal Disease (ESRD) Population for Improving Blood Pressure Control
Randomized Clinical Trial Evaluating Different Protocols for Improving the Way of Getting the Best Dry Weight for Hemodialysis Patients, Looking for Blood Pressure Control, Measured by ABPM
End-stage renal disease (ESRD) is a common clinical condition. In this population, the prevalence of systemic hypertension is high and its adequate control can determinate the outcome.
The first step for a good control of blood pressure in renal patients is adjusting his/her dry weight. Actually, dry weight is assessed based on clinical examination and blood pressure.
The electrical bioimpedance is a simple and portable device. The investigators design a randomized clinical trial for evaluating two ways of getting the best dry weight for hemodialysis patients.
A basal 24h ABPM will be taken before the randomization. Then, 2 weeks later the dry weight be revised, the investigators will get a second 24h ABPM.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
End-stage renal disease (ESRD) is a common clinical condition over the world. In this population, the prevalence of systemic hypertension is high and its adequate control can determinate the outcome.
The first step for a good control of blood pressure is giving a dry weight for the patient. We can understand dry weight or target weight as that one which the patient feels comfortable and there aren't clinical signals of volemic overload as edema, dyspnea, orthopnea, jugular turgency, hepatomegalia. Classically, the dry weight is assessed based on clinical examination, blood pressure and experience of hemodialysis staff.
The electrical bioimpedance is a very simple method that possibilities access the corporal compartments, including the body water, using a small and not expensive portable device.
Trying to study new forms for getting the ideal dry weight, we design a randomized clinical trial for evaluating two ways of getting a dry weight for hemodialysis patients.
One group will be dry weight fixed by bioimpedance data and in another group the dry weight will by a clinical protocol.
We will take a 24h ABPM basal from all patients before the randomization. Then, 2 weeks later the dry weight be revised, a second ABPM will be taken. The results will be compared.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Rio Grande do Sul
-
Carazinho, Rio Grande do Sul, Brazil, 99500-000
- Darlan Martins Lara
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients with ESRD, clinically stable, under hemodialysis therapy at two clinics in the North of Rio Grande do Sul.
Exclusion Criteria:
- Clinical unstability, like: infection in course ou recent acute cardiovascular disease (less then 3 months).
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Clinical dry weight
Group which the dry weight will be assessed based on clinical examination.
|
Each patient will be submitted a clinical evaluation, considering signals of overload.
|
Active Comparator: Bioimpedance
Group which the dry weight will be assessed by bioimpedance data.
|
From electrical bioimpedance data, will be fixed a revised dry weight for each patient.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Diastolic and systolic blood pressure assessed by ABPM
Time Frame: after 2 weeks
|
A basal measure will be taken at the start point.
Then, the dry weight will be evaluated by clinical or BIA method.
After 2 weeks of tree times-week sections of hemodialysis under the revised dry weight, a second measure of ABPM will be performed.
|
after 2 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
intradialytic signals and/or symptoms
Time Frame: during two weeks
|
the intradialytic signals and/or symptoms will be assessed by dialysis registers, before and after de revision of dry weight
|
during two weeks
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Darlan M Lara, MD MsC, Fedral University of Rio Grande do Sul
- Study Chair: Miguel Gus, MD PhD., Federal University of Rio Grande do Sul
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- DryWeightESRDxBloodPressure
- ESRD
- BLOOD PRESSURE
- Dry weight
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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