Cytokine Assay for Early Identification of Pediatric Stem Cell Transplant Recipients

Cytokine Assay for Early Identification of Pediatric Stem Cell Transplant Recipients at Risk for Respiratory Failure

The aim of our study is to determine whether a clinically relevant laboratory measurement (of seven specific immunologic biochemicals in the blood) can identify which bone marrow transplant recipients are likely to progress to respiratory failure. Our ultimate goal is to devise a comprehensive and inclusive laboratory test that is effective at determining who is likely to go on to respiratory failure, in order to facilitate early medical intervention.

Study Overview

• Status: Terminated
• Conditions: Blood Stem Cell Transplant Failure

• Study Type: Observational
• Enrollment (Anticipated): 50

Contacts and Locations

• Study Contact: Name: Kimberly Boynton; Phone Number: (650) 498-6713; Email: boynton@stanford.edu

Study Locations

• United States
  • California
    • Stanford, California, United States, 94305
      • Stanford University School of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 21 years (Child, Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Hematopoietic stem cell transplantation (HSCT) for any indication.

Description

Inclusion Criteria:- Hematopoietic stem cell transplantation (HSCT) for any indication.

• Patients will range from age 0 to age 21. There is no gender restriction. We expect the male to female ratio to end up being about 50/50
• Ability to understand and the willingness to sign a written informed consent document.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Compute median flourescence intensity, standard curves, and estimated pg/mL for each cytokine.	weekly during hospitalization for transplant

Collaborators and Investigators

• Sponsor: Stanford University
• Investigators: Principal Investigator: Rajni Agarwal-Hashmi, Stanford University

Study record dates

Study Major Dates

• Study Start: July 1, 2008
• Primary Completion (Actual): December 1, 2010
• Study Completion (Actual): January 1, 2011

Study Registration Dates

• First Submitted: June 1, 2010
• First Submitted That Met QC Criteria: June 1, 2010
• First Posted (Estimate): June 2, 2010

Study Record Updates

• Last Update Posted (Actual): April 10, 2023
• Last Update Submitted That Met QC Criteria: April 7, 2023
• Last Verified: April 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: PEDSBMT199; SU-09222008-1301 (Other Identifier: Stanford University); PEDSHSCT0002 (Other Identifier: Stanford University - Previous OnCore ID); 14862 (Other Identifier: stanford IRB)