- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01445158
Pilot Study of Educational Interventions in Pediatric Hematopoietic Stem Cell Donors to Increase Knowledge of Donation and Transplantation Procedures
May 4, 2020 updated by: National Cancer Institute (NCI)
Background:
- Hematopoietic Stem Cell Transplant (HSCT) represents the second most frequent major organ transplant in the United States.
- Pediatric 1st degree stem cell donors can experience a variety of psychological difficulties before and after donation with those who feel they are not adequately prepared for possible complications following stem cell donation and transplant describing negative emotions.
- The importance of preparation for children undergoing medical procedures has long been recognized in the field of pediatric psychology
Objectives:
- To assess how prepared pediatric donors are for stem cell donation by assessing their knowledge about stem cell transplants, and to assess their anxiety at different stages of the donation process.
- To assess the effectiveness of a workbook and a board game as tools for conveying information on donation and transplantation to donors.
- To identify donors who may require additional preparation before stem cell collection.
- To explore the relationship between donor knowledge and anxiety symptoms.
Eligibility:
-Stem cell donors ages 10 to 26 years of age
Design:
- Participant s baseline knowledge and anxiety are evaluated.
- Participant s knowledge is reassessed and anxiety evaluated following an information session with the research nurse and doctor about the procedures for stem cell donation and discussion of the consent form for the transplant protocol.
- Participants are separated into two groups. Donors 10 to 15 years of age play a board game; those 16 to 26 years of age are given a workbook on stem cell transplant.
- Participants knowledge and anxiety are reassessed within 24 hours after working with the educational materials and again 1 month later.
Study Overview
Status
Completed
Conditions
Detailed Description
Background:
- Hematopoietic Stem Cell Transplant (HSCT) represents the second most frequent major organ transplant in the United States.
- A variety of psychological difficulties in sibling donors post-stem cell donation are reported, including withdrawal, guilt, anger, depression, anxiety, mild to severe psychopathology, and post-traumatic stress symptomatology.
- The importance of preparation for children undergoing medical procedures has long been recognized in the field of pediatric psychology. In previous research, siblings who felt they were not adequately prepared for possible complications following HSCT donation and transplant often described negative emotions.
- Some siblings have reported feeling pressured and coerced to become a donor, while others describe a lack of attention to their physical fears associated with donation and their psychological concerns.
- No prospective studies examining educational tools and transplant knowledge in sibling stem cell donors are currently available.
Objectives:
- To assess pediatric 1st degree stem cell donor comprehension of transplant procedures and compare knowledge prior to educational interventions (pre and post-consent informational session) to knowledge following educational interventions.
- To assess the effectiveness of a workbook intervention as a learning tool for conveying information on stem cell donation and transplantation to pediatric donors.
- To assess the effectiveness of a board game intervention (ShopTalk) as a learning tool for conveying information on stem cell donation and transplantation to pediatric donors.
- To identify donors who may require additional preparation prior to stem cell collection.
- To measure donor anxiety pre and post the educational intervention and stem cell donation and explore the relationship between donor knowledge and anxiety symptoms.
Eligibility:
- Age: 10 to 26 years of age
- Participants or their parents must consent to participation in active bone marrow and peripheral blood stem cell transplant protocols at the NIH.
- For donors less than 18 years of age, their legal guardian must give informed consent, the donor must give written assent.
- For donors greater than or equal to 18 years of age, ability to give informed consent.
- Participants must understand and read English or Spanish.
Design:
- Baseline knowledge will be assessed following consent.
- Knowledge will be reassessed following the information session for the transplant protocol
- Donors will be stratified into 2 groups by age. Donors ages 10 to 15 will be scheduled the following day to play a game called ShopTalk. Donors ages 16 to 26 will be given a workbook on HSCT specifically designed for 1st degree stem cell donors. Knowledge will be reassessed following the administration of these interventions.
- A follow-up assessment will be administered to all participants 1 month after the post intervention test was administered.
Study Type
Observational
Enrollment (Actual)
19
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Maryland
-
Bethesda, Maryland, United States, 20892
- National Institutes of Health Clinical Center, 9000 Rockville Pike
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
10 years to 26 years (Child, Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Description
- INCLUSION CRITERIA:
- Age: 10 to 26 years of age.
- Participants or their parents must consent to participation in active bone marrow and peripheral blood stem cell transplant protocols at the NIH.
- For donors less than 18 years of age, their legal guardian must give informed consent, the donor must give written assent.
- For donors greater than or equal to 18 years of age, ability to give informed consent.
- Participants must understand and read English or Spanish.
EXCLUSION CRITERIA:
- Presence of psychiatric or psychological symptoms which in the judgment of the Principal or Associate Investigators would compromise the donor's ability to engage in the intervention or is likely to interfere with the study procedures or results.
- Preciously identified cognitive impairment, which in the judgment of the Principal or Associate Investigators would compromise the donor's ability to understand the educational materials or the board game rules and procedures, and is likely to interfere with the study procedures or results.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
1
bone marrow or stem cell donors ages 10 to 15
|
2
bone marrow or stem cell donors ages 16 to 26
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assess 1st degree relative stem cell donor comprehension of transplant procedures
Time Frame: Prior to relatives transplant
|
results of donor quiz and anxiety assessment
|
Prior to relatives transplant
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assess efficacy of workbook intervention as a learning tool
Time Frame: Prior to relatives transplant
|
results of final quiz after workbook intervention
|
Prior to relatives transplant
|
Assess effectiveness of a board game as a learning tool
Time Frame: Prior to relatives transplant
|
results of final quiz after board game
|
Prior to relatives transplant
|
Measure donor anxiety pre-and post educational intervention and pre- and and post educational intervention and pre and post donation
Time Frame: Prior to relatives transplant
|
results of anxiety assessment, administered 1 month from initial post intervention test
|
Prior to relatives transplant
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Lipton JM. Peripheral blood as a stem cell source for hematopoietic cell transplantation in children: is the effort in vein? Pediatr Transplant. 2003;7 Suppl 3:65-70. doi: 10.1034/j.1399-3046.7.s3.10.x.
- Grupp SA, Frangoul H, Wall D, Pulsipher MA, Levine JE, Schultz KR. Use of G-CSF in matched sibling donor pediatric allogeneic transplantation: a consensus statement from the Children's Oncology Group (COG) Transplant Discipline Committee and Pediatric Blood and Marrow Transplant Consortium (PBMTC) Executive Committee. Pediatr Blood Cancer. 2006 Apr;46(4):414-21. doi: 10.1002/pbc.20800.
- Wiley FM, Lindamood MM, Pfefferbaum-Levine B. Donor-patient relationship in pediatric bone marrow transplantation. J Assoc Pediatr Oncol Nurses. 1984 Summer;1(3):8-14. doi: 10.1177/104345428400100304. No abstract available.
Helpful Links
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 18, 2007
Primary Completion (Actual)
September 20, 2017
Study Completion (Actual)
May 4, 2020
Study Registration Dates
First Submitted
September 30, 2011
First Submitted That Met QC Criteria
September 30, 2011
First Posted (Estimate)
October 3, 2011
Study Record Updates
Last Update Posted (Actual)
May 5, 2020
Last Update Submitted That Met QC Criteria
May 4, 2020
Last Verified
May 1, 2020
More Information
Terms related to this study
Other Study ID Numbers
- 070086
- 07-C-0086
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Normal Donors
-
AmgenCompleted
-
Vietnam National UniversityMerck Sharp & Dohme LLC; Aarhus University Hospital; University of Southern Denmark and other collaboratorsCompleted
-
National Institute of Allergy and Infectious Diseases...CompletedLiving Donors | Tissue Donors
-
Terumo BCTCompletedHealthy Apheresis Donors | Mononuclear (MNC) Cell DonorsUnited States
-
Ohio UniversityNational Heart, Lung, and Blood Institute (NHLBI); New York Blood CenterCompleted
-
Universidad Peruana Cayetano HerediaCompleted
-
Amit GargCanadian Institutes of Health Research (CIHR)CompletedLiving Kidney DonorsUnited States, Canada, Australia
-
Guangzhou Blood CenterUnknown
-
First Affiliated Hospital, Sun Yat-Sen UniversityCompleted
-
Oslo University HospitalCompleted