Alleviating the Metabolic Side Effects of Antipsychotic Medications

A Randomised Trial Examining the Effectiveness of Sympathetic Nervous Inhibition in Alleviating the Metabolic Side Effects of Antipsychotic Medications in Patients With Schizophrenia

The use of antipsychotic medications has increased over the past decade. While more recently developed medications are improved with regards to extrapyramidal side effects, the use of atypical antipsychotics has been associated with substantial weight gain and a worsening of metabolic profile. The time course and extent of weight gain differs among antipsychotics, with olanzapine and clozapine being associated with greatest weight gain.

Mechanisms underlying a worsening metabolic profile, obesity and obesity-related illnesses are complex, extending beyond sedentary lifestyle, poor diet and genetic predisposition. There is also a growing body of evidence that the sympathetic nervous system (SNS) has a role in the generation of both obesity and obesity-related illness. While the role of the SNS in blood pressure control is readily acknowledged it is less well appreciated that activation of the SNS exerts profound metabolic effects.

Although the fact of a causal relation linking antipsychotic drugs and obesity is unequivocally established, the biological mechanisms operating are unclear, and strategies for preventive therapy remain largely unformulated.

This study aims to investigate the role of the SNS and its association with the metabolic abnormalities that are frequently observed in patients with schizophrenia following treatment with antipsychotic medications.

Additionally, the study will investigate whether treatment with the centrally acting sympatholytic agent moxonidine will modify SNS activity and, hence, favourably influence the downstream metabolic abnormalities seen in antipsychotic treated patients with schizophrenia.

Hypothesis 1: Elevated sympathetic nervous system activity underlies the metabolic disturbances observed in patients following antipsychotic therapy.

Aim 1: To investigate the role of the sympathetic nervous system and its association with the metabolic abnormalities that are frequently observed in patients with schizophrenia following treatment with antipsychotic medications

Hypothesis 2: Central sympathoinhibition with moxonidine will blunt the elevated sympathetic nervous activity and downstream metabolic abnormalities observed in antipsychotic treated patients with schizophrenia.

Aim 2: Determine whether treatment with the centrally acting sympatholytic agent moxonidine will modify sympathetic nervous system activity and, hence, favourably influence the downstream metabolic abnormalities seen in antipsychotic treated patients with schizophrenia.

Study Overview

• Status: Withdrawn
• Conditions: Schizophrenia
• Intervention / Treatment: Drug: Moxonidine; Drug: Placebo

• Study Type: Interventional
• Phase: Phase 4

Contacts and Locations

Study Locations

• Australia
  • Victoria
    • Ballarat, Victoria, Australia
      • Ballarat Health Service Psychiatric Services
    • Clayton, Victoria, Australia
      • Monash Medical Centre - Monash Health
    • Melbourne, Victoria, Australia
      • Alfred and Baker Medical Unit - Alfred Hospital
    • Melbourne, Victoria, Australia
      • Baker IDI Heart & Diabetes Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 63 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Aged 18-65 years.
• Capable of understanding and willing to provide signed and dated written, voluntary informed consent in advance of any protocol-specific procedures.
• Psychiatrist confirmed diagnosis of schizophrenia.
• Stabilised on clozapine or olanzapine for at least 6 weeks.
• 5% increase in body weight since commencement of clozapine or olanzapine.

Exclusion Criteria:

• Aged < 18 or > 65 years.
• On a Community Treatment Order (CTO).
• Comorbid mental health conditions including schizoaffective disorder, personality disorders, eating disorders, mental retardation, pervasive developmental disorder, delirium, dementia (ie, Mini Mental State Examination [MMSE] < 23), and amnesia.
• Concurrent treatment with two or more antipsychotics (including clozapine or olanzapine) at screening.
• Concomitant treatment with sedatives, tricyclic antidepressants, metformin, insulin or beta adrenergic blocking agents.
• Known or suspected hypersensitivity to moxonidine.
• Previous history of clozapine induced myocarditis.
• Pre-existing and/or current diagnosed heart disease.
• Comorbid medical conditions including medicated hypertension, bradycardia (heart rate < 50 beats/min), type 1 diabetes, epilepsy, bleeding disorders, alcohol/drug dependence, infectious blood diseases, and moderate-severe renal impairment.
• Clinically significant abnormalities on examination or laboratory testing, and clinically significant medical conditions not listed above that are serious and/or unstable.
• Pregnant or breastfeeding women.
• Women of childbearing potential (WOCP) who are not using medically accepted contraception (ie, intrauterine devices [IUDs], hormonal contraceptives [oral, depot, patch or injectable], and double barrier methods such as condoms or diaphragms with spermicidal gel or foam. Women who are postmenopausal (ie, amenorrhea for at least 12 consecutive months) or surgically sterile are not considered to be WOCP.
• Sexually active men with WOCP partners who are not using medically accepted contraception.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Olanzapine; Participants taking olanzapine at the time of recruitment will continue to take this medication as part of standard care for schizophrenia.	Drug: Moxonidine; Participants who are randomly assigned to the moxonidine/experimental group will be treated with moxonidine oral tablets for twelve weeks. Participants will begin their moxonidine treatment at 0.2mg dosage, which will be increased to 0.4mg over the first two weeks. At the end of the twelve weeks of treatment, participants will be withdrawn from moxonidine over a period of two weeks.; Other Names: Physiotens; Drug: Placebo; To examine the effects of moxonidine treatment, a placebo oral tablet will be used for comparison purposes. The duration and number of placebo tablets participants will be required to take will be the same as the amount required in the moxonidine group.
Other: Clozapine; Participants taking clozapine at the time of recruitment will continue to take this medication as part of standard care for schizophrenia.	Drug: Moxonidine; Participants who are randomly assigned to the moxonidine/experimental group will be treated with moxonidine oral tablets for twelve weeks. Participants will begin their moxonidine treatment at 0.2mg dosage, which will be increased to 0.4mg over the first two weeks. At the end of the twelve weeks of treatment, participants will be withdrawn from moxonidine over a period of two weeks.; Other Names: Physiotens; Drug: Placebo; To examine the effects of moxonidine treatment, a placebo oral tablet will be used for comparison purposes. The duration and number of placebo tablets participants will be required to take will be the same as the amount required in the moxonidine group.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To determine the association between sympathetic nervous system and metabolic abnormalities (eg, weight gain) observed with antipsychotic treatment.	To investigate the role of the sympathetic nervous system and it's association with the metabolic abnormalities that are frequently observed in patients with schizophrenia who are treated with antipsychotic medications; namely clozapine and olanzapine.	Baseline and following 12 weeks of moxonidine/placebo treatment.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in sympathetic nervous system activity.	We will explore whether treatment with the centrally acting sympatholytic agent, moxonidine, modifies sympathetic nervous system activity and hence, has a favourable influence on the downstream metabolic abnormalities seen in schizophrenic patients treated with antipsychotics.	Baseline and following 12 weeks of moxonidine/placebo treatment.

Collaborators and Investigators

• Sponsor: Baker Heart and Diabetes Institute
• Collaborators: The Alfred; Monash Medical Centre; Ballarat Health Services
• Investigators: Study Director: Gavin Lambert, Baker IDI Heart & Diabetes Institute; Principal Investigator: David Barton, Monash Medical Centre; Principal Investigator: Abdul Khalid, Ballarat Health Services

Study record dates

Study Major Dates

• Study Start: May 1, 2012

Study Registration Dates

• First Submitted: March 25, 2012
• First Submitted That Met QC Criteria: March 29, 2012
• First Posted (Estimate): March 30, 2012

Study Record Updates

• Last Update Posted (Actual): April 24, 2019
• Last Update Submitted That Met QC Criteria: April 23, 2019
• Last Verified: April 1, 2019

More Information

Terms related to this study

• Keywords: Schizophrenia; Sympathetic nervous system activation; Moxonidine; Cardiometabolic side effects of antipsychotics
• Additional Relevant MeSH Terms: Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders; Schizophrenia; Antihypertensive Agents; Moxonidine
• Other Study ID Numbers: 108/12; 1022794 (Other Grant/Funding Number: NHMRC)