- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01608373
The Effect of Intravenous Lidocaine and Intraperitoneal Lidocaine Irrigation on Pain After Laparoscopic Cholecystectomy
Comparison of Intravenous Lidocaine and Intraperitoneal Lidocaine Irrigation for Effective Pain Relief After Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-blind, Placebo-controlled Study
This prospective randomized study aims to comparison the effectiveness of intravenous lidocaine injection and intraperitoneam lidocaine irrigation on the relief of pain in patients undergoing laparoscopic cholecystectomy.
A total of 83 patients will be randomized into one of three groups (group C or group I or group P) based on Excel number generation.
Patients in group C will receive normal saline intravenous injection, and patients in group I will receive an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.
Patients in group P will receive intraperitoneal lidocaine irrigation with 3.5 mg/kg lidocaine and normal saline 100cc.
Visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (FPB) of a patient-controlled analgesia system will be recorded at 2, 4, 8, 12, 24, 48 hours postoperatively.
Study Overview
Status
Conditions
Study Type
Enrollment (Anticipated)
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
-
Seoul, Korea, Republic of
- Recruiting
- Hyun Kang
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Laparoscopic cholecystectomy
Exclusion Criteria:
- mental change
- allergy to local anesthetics
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Intravenous lidocaine injection group
Patients in Group I (intravenous lidocaine injection group) received an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.
|
Patients in Group I (intravenous lidocaine injection group) received an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr
Other Names:
|
Active Comparator: Intraperitoneal lidocaine irrigation group
Patients in Group P(intraperitoneal lidocaine irrigation group) receive a peritoneal lidocaine irrigation with 3.5mg/kg lidocaine and normal saline 100cc.
|
Patients in Group P(intraperitoneal lidocaine irrigation group) receive a peritoneal lidocaine irrigation with 3.5mg/kg lidocaine and normal saline 100cc.
50cc of irrigation fluid will be spread below diaphragm and 50cc of irrigation fluid will be spread around the gall bladder.
Other Names:
|
Placebo Comparator: Intravenous normal saline group
The patients in Group C (placebo control group) received normal saline intravenous injection
|
The patients in Group C (placebo control group) received normal saline intravenous injection
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Postoperative pain measuring using Visual analogue scale at postoperative 2hour
Time Frame: Post op 2 hour
|
Patients will be assessed for pain using a visual analogue pain scale (VAS). It is usually a horizontal line, 100 mm in length, anchored by word descriptors at each end; left side end which represents 0 is 'No pain', right side end with 100 is 'Very severe pain'. The patient marks on the line the point that they feel represents their perception of their current state. The VAS score is determined by measuring in millimeters from the left hand end of the line to the point that the patient marks. To check the severity of pain VAS will be measured at post op 2hour. |
Post op 2 hour
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Visual analogue scale 4hour
Time Frame: Post op 4 hour
|
Patients will be assessed for pain using a visual analogue pain scale (VAS). It is usually a horizontal line, 100 mm in length, anchored by word descriptors at each end; left side end which represents 0 is 'No pain', right side end with 100 is 'Very severe pain'. The patient marks on the line the point that they feel represents their perception of their current state. The VAS score is determined by measuring in millimeters from the left hand end of the line to the point that the patient marks. To check the severity of pain VAS will be measured at post op 4hour. |
Post op 4 hour
|
Visual analogue scale 8hour
Time Frame: Post op 8 hour
|
Patients will be assessed for pain using a visual analogue pain scale (VAS). It is usually a horizontal line, 100 mm in length, anchored by word descriptors at each end; left side end which represents 0 is 'No pain', right side end with 100 is 'Very severe pain'. The patient marks on the line the point that they feel represents their perception of their current state. The VAS score is determined by measuring in millimeters from the left hand end of the line to the point that the patient marks. To check the severity of pain VAS will be measured at post op 8hour. |
Post op 8 hour
|
Visual analogue scale 12 hour
Time Frame: Post op 12hour
|
Patients will be assessed for pain using a visual analogue pain scale (VAS). It is usually a horizontal line, 100 mm in length, anchored by word descriptors at each end; left side end which represents 0 is 'No pain', right side end with 100 is 'Very severe pain'. The patient marks on the line the point that they feel represents their perception of their current state. The VAS score is determined by measuring in millimeters from the left hand end of the line to the point that the patient marks. To check the severity of pain VAS will be measured at post op 12hour. |
Post op 12hour
|
visual analogue scale 24hour
Time Frame: Post op 24hour
|
Patients will be assessed for pain using a visual analogue pain scale (VAS). It is usually a horizontal line, 100 mm in length, anchored by word descriptors at each end; left side end which represents 0 is 'No pain', right side end with 100 is 'Very severe pain'. The patient marks on the line the point that they feel represents their perception of their current state. The VAS score is determined by measuring in millimeters from the left hand end of the line to the point that the patient marks. To check the severity of pain VAS will be measured at post op 24hour. |
Post op 24hour
|
Visual analogue scale 48 hour
Time Frame: Post op 48hour
|
Patients will be assessed for pain using a visual analogue pain scale (VAS). It is usually a horizontal line, 100 mm in length, anchored by word descriptors at each end; left side end which represents 0 is 'No pain', right side end with 100 is 'Very severe pain'. The patient marks on the line the point that they feel represents their perception of their current state. The VAS score is determined by measuring in millimeters from the left hand end of the line to the point that the patient marks. To check the severity of pain VAS will be measured at post op 48hour. |
Post op 48hour
|
Opioid consumption 2hour
Time Frame: Post op 2 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
In the case of persistent pain greater than a visual analogue scale (VAS) pain score of 30 mm, an additional 50 μg of fentanyl will be injected intra-venously by nursing staff until the pain was relieved to a level less than a VAS pain score of 30 mm.
And sum of delivery from PCA system and additional opioid fom immediately after operation to post op 2hour will be measured.
|
Post op 2 hour
|
Opioid consumption 4 hour
Time Frame: Post op 4 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
In the case of persistent pain greater than a visual analogue scale (VAS) pain score of 30 mm, an additional 50 μg of fentanyl will be injected intra-venously by nursing staff until the pain was relieved to a level less than a VAS pain score of 30 mm.
And sum of delivery from PCA system and additional opioid fom immediately after operation to post op 4hour will be measured.
|
Post op 4 hour
|
Opioid consumption 8 hour
Time Frame: Post op 8 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
In the case of persistent pain greater than a visual analogue scale (VAS) pain score of 30 mm, an additional 50 μg of fentanyl will be injected intra-venously by nursing staff until the pain was relieved to a level less than a VAS pain score of 30 mm.
And sum of delivery from PCA system and additional opioid fom immediately after operation to post op 8hour will be measured.
|
Post op 8 hour
|
Opioid consumption 12 hout
Time Frame: Post op 12 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
In the case of persistent pain greater than a visual analogue scale (VAS) pain score of 30 mm, an additional 50 μg of fentanyl will be injected intra-venously by nursing staff until the pain was relieved to a level less than a VAS pain score of 30 mm.
And sum of delivery from PCA system and additional opioid fom immediately after operation to post op 12hour will be measured.
|
Post op 12 hour
|
Opioid consumption 24 hour
Time Frame: Post op 24 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
In the case of persistent pain greater than a visual analogue scale (VAS) pain score of 30 mm, an additional 50 μg of fentanyl will be injected intra-venously by nursing staff until the pain was relieved to a level less than a VAS pain score of 30 mm.
And sum of delivery from PCA system and additional opioid fom immediately after operation to post op 24hour will be measured.
|
Post op 24 hour
|
Opioid consumption 48hour
Time Frame: Post op 48 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
In the case of persistent pain greater than a visual analogue scale (VAS) pain score of 30 mm, an additional 50 μg of fentanyl will be injected intra-venously by nursing staff until the pain was relieved to a level less than a VAS pain score of 30 mm.
And sum of delivery from PCA system and additional opioid fom immediately after operation to post op 48hour will be measured.
|
Post op 48 hour
|
FPB 2 hour
Time Frame: Post op 2 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
And total frequency of patient to push the button of the PCA machine (FPB) fom immediately after operation to post op 2 hour will be measured.
|
Post op 2 hour
|
FPB 4 hour
Time Frame: Post op 4 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
And total frequency of patient to push the button of the PCA machine (FPB) fom immediately after operation to post op 4 hour will be measured.
|
Post op 4 hour
|
FPB 8 hour
Time Frame: Post op 8 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
And total frequency of patient to push the button of the PCA machine (FPB) fom immediately after operation to post op 8 hour will be measured.
|
Post op 8 hour
|
FPB 12 hour
Time Frame: Post op 12 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
And total frequency of patient to push the button of the PCA machine (FPB) fom immediately after operation to post op 12 hour will be measured.
|
Post op 12 hour
|
FPB 24 hour
Time Frame: Post op 24hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
And total frequency of patient to push the button of the PCA machine (FPB) fom immediately after operation to post op 24 hour will be measured.
|
Post op 24hour
|
FPB 48 hour
Time Frame: Post op 48 hour
|
The patients will be taught to push the button of the PCA system, which delivered a bolus of drug, each time pain occurred.
And total frequency of patient to push the button of the PCA machine (FPB) fom immediately after operation to post op 48 hour will be measured.
|
Post op 48 hour
|
Collaborators and Investigators
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Postoperative Complications
- Pain
- Neurologic Manifestations
- Pain, Postoperative
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Anti-Arrhythmia Agents
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Sensory System Agents
- Anesthetics
- Membrane Transport Modulators
- Anesthetics, Local
- Voltage-Gated Sodium Channel Blockers
- Sodium Channel Blockers
- Lidocaine
Other Study ID Numbers
- ChungAngUH4
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