Fracture and Fall Prevention in Elderly With Osteoporosis

Osteoporosis is a prevalent health concern among older adults and is associated with an increased risk of falls that can cause fracture, injury or mortality. Identifying the factors related to falls occurring within this population is essential for the development of effective regimes for fall prevention. Studies have shown that muscle quality and good posture alignments are critical for balance control in older adults. People are diagnosed with osteoporosis often combining with muscles weakness, and increased spine kyphosis leading vertebral, fractures and poor balance control, even falls. Therefore, improving muscle quality, strengthening weak muscles and correcting postural alignment are essential elements for fracture and fall prevention in older adults with osteoporosis. The long-term objectives of this work are to prevent fracture and fall in older adults with osteoporosis by improving the function of degenerative muscles using exercise training.

Study Overview

• Status: Unknown
• Conditions: Osteoporosis
• Intervention / Treatment: Behavioral: personalized core muscle training program

• Study Type: Interventional
• Enrollment (Anticipated): 80
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan, 10055
    • Recruiting
    • Physical Therapy Center or the Orthopedic Center in the National Taiwan University Hospital
    • Contact: Weili Hsu, PhD; Phone Number: 886-2-3366-8127; Email: wlhsu@ntu.edu.tw

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

The inclusion criteria for osteopenia or osteoporosis group:

1. able to stand and walk for 5 minutes independently;
2. having normal or corrected to normal vision;
3. having age between > 50 years
4. with osteopenia (-2.5 < t-score < -1.0) or osteoporosis (t-score <-2.5).

The exclusion criteria for osteopenia or osteoporosis group:

1. being pregnant;
2. sensory-motor deficits;
3. inability of communication
4. lack of access to a telephone.

The inclusion criteria for control age-matched group:

1. able to stand and walk for 5 minutes independently;
2. having normal or corrected to normal vision;
3. having age between > 50 years
4. without osteopenia or osteoporosis (t-score > -1.0).

The exclusion criteria for control age-matched group:

1. being pregnant;
2. sensory-motor deficits;
3. inability of communication
4. lack of access to a telephone.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Exercise; Participants are allocated to the exercise group will commence the personalized core training exercise with EMG biofeedback based on their testing results in muscle quality.

Behavioral: personalized core muscle training program; Participants are allocated to the exercise group will commence the personalized core training exercise with EMG biofeedback based on their testing results in muscle quality. The program will run for 3 months with patients attending for one hour three times a week. The age-matched control group will maintain their usual daily life activities without any specific instruction. The exercise training will be run by an experienced physiotherapist, who will encourage patients individually to progress at their own pace.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Changes of torque demand to capacity ratio 6 months	Change from Baseline intorque demand to capacity ratio at 6 months
Changes of torque demand to capacity ratio at 3 months	Change from Baseline in torque demand to capacity ratio at 3 months
Change of torque demand to capacity ratio at 12months	Change from Baseline in torque demand to capacity ratio at 12 months

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital
• Investigators: Principal Investigator: Weili Hsu, PhD, National Taiwan University Hospital

Study record dates

Study Major Dates

• Study Start: January 1, 2010
• Primary Completion (Anticipated): December 1, 2015
• Study Completion (Anticipated): December 1, 2015

Study Registration Dates

• First Submitted: October 5, 2012
• First Submitted That Met QC Criteria: November 20, 2012
• First Posted (Estimate): November 27, 2012

Study Record Updates

• Last Update Posted (Estimate): November 27, 2012
• Last Update Submitted That Met QC Criteria: November 20, 2012
• Last Verified: November 1, 2012

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Metabolic Diseases; Musculoskeletal Diseases; Bone Diseases; Bone Diseases, Metabolic; Osteoporosis
• Other Study ID Numbers: 201003065R