- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01743716
Genetic and Neural Predictors of Adolescent Depression
Towards Identification of Genetic and Neural Predictors of Adolescent Depression
Study Overview
Status
Conditions
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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-
Massachusetts
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Belmont, Massachusetts, United States, 02478
- McLean Hospital
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Adult Cohort
A. MDD Mothers Cohort Inclusion Criteria:
- Current or past Major Depressive Disorder
- English as first language or English fluency
- Biological daughter who meets inclusion/exclusion criteria for High Risk Female Adolescent
B. Healthy Control Mothers Cohort Inclusion Criteria:
- No history of psychopathology
- English as first language or English fluency
- Biological daughter who meets inclusion/exclusion criteria for Healthy Female Adolescent
Adolescent Cohort
General Inclusion Criteria for Adolescent Cohorts:
- Female
- Ages 12-14
- English as first language or English fluency
- Right handed
General Exclusion Criteria for Adolescent Cohorts:
- Past or present diagnosis of Major Depressive Disorder
- Past or present diagnosis of any anxiety disorder
- Past or present diagnosis of Bipolar Disorder
- Past or present diagnosis of ADHD
- Presence of medical or neurological illness (head injury, loss of consciousness greater than 5 minutes, seizure)
- Current use of psychotropic medication
Presence of any contraindication for MRI:
- Cardiac pacemakers
- Metal clips on blood vessels (also called stents)
- Artificial heart valve, artificial arms, hands, legs, etc.
- Brain stimulator devices
- Implanted drug pumps
- Ear or eye implants
- Known metal fragments in eyes
- Exposure to metal filings or shrapnel (sheet metal workers, welders, and others)
- Other metallic surgical hardware in vital area
- Certain tattoos with metallic ink
- Certain IUDs containing metal
- Certain transdermal (skin) patches such as:
- NicoDerm (nicotine for tobacco dependence)
- Transderm Scop (scopolamine for motion sickness)
Ortho Evra (birth control)
- Positive urine pregnancy test
C. High Risk Female Adolescent Additional Inclusion Criterion:
• Biological daughter of participant in the MDD Mothers cohort
D. Healthy Female Adolescent Additional Inclusion Criterion:
• Biological daughter of participant in the Healthy Control Mothers cohort
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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MDD Mothers
Adult women with a history of major depressive disorder (MDD) and a healthy adolescent daughter between the ages of 12-14
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Healthy Control Mothers
Adult women with no history of psychopathology and an adolescent daughter between the ages of 12-14
|
High Risk Female Adolescents
Healthy female adolescents aged 12-14 with a mother in the MDD Mothers cohort
|
Healthy Female Adolescents
Healthy female adolescents aged 12-14 with a mother in the Healthy Control Mothers cohort.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Neurobiological Activity in Frontostriatal and Mesolimbic Regions
Time Frame: Baseline
|
Baseline
|
Depressive Symptoms
Time Frame: 6 months
|
6 months
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Diego A. Pizzagalli, PhD, McLean Hospital
- Principal Investigator: Randy P. Auerbach, PhD, McLean Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2012P002351
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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