- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01765491
Comparison of Two Methods of Bowel Preparation for Colonoscopy in Hospitalized Patients
June 14, 2023 updated by: Bashar Attar MD, Cook County Health
Comparison of Morning-only With Split-dose Polyethylene Glycol for Colonoscopy Preparation in Hospitalized Patients: A Randomized Controlled Non-Inferiority Study
Morning-only colonoscopy preparation may improve efficiency by allowing same-day patient preparation and colonoscopy.
The aim of the investigators study is to compare the efficacy and tolerability of morning-only Polyethylene Glycol (PEG) to split-dose preparation in hospitalized patients undergoing colonoscopy.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
This is a single-center, prospective, endoscopist-blinded study in which hospitalized patients scheduled to undergo diagnostic colonoscopy were randomly assigned to receive one gallon of PEG either the morning of colonoscopy or as a split-dose (evening-morning).
The primary end point is efficacy of colonoscopy preparation measured by the Ottawa scale.
The investigators pre-specified a non-inferiority margin of 1.5 for the difference in Ottawa scale between arms.
Secondary end points are patient compliance and tolerance.
N: 120 hospitalized patients scheduled for diagnostic colonoscopy.
Study Type
Interventional
Enrollment (Actual)
120
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Illinois
-
Chicago, Illinois, United States, 60612
- John H Stroger Jr Hospital of Cook County
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Adult patients scheduled to undergo diagnostic colonoscopy during hospitalization
Exclusion Criteria:
- Critically ill/Intensive Care Unit patients
- Suspected bowel obstruction/perforation
- History of colon resection
- Patients with altered mental status/inability to provide informed consent
- Incarcerated patients
- Pregnant females
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Morning-only polyethylene glycol
One gallon of polyethylene glycol to be taken between 5am and 9am on the day of colonoscopy.
|
One gallon of polyethylene glycol to be taken between 5am and 9am on the day of colonoscopy
|
Active Comparator: Split-dose polyethylene glycol
Half gallon of polyethylene glycol to be taken between 7-9 pm on the day before colonoscopy and the remaining half between 7-9 am on the day of colonoscopy.
|
Half gallon of polyethylene glycol to be taken between 7-9 pm on the day before colonoscopy and the remaining half between 7-9 am on the day of colonoscopy
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
To compare the efficacy of colonoscopy preparation measured by the Ottawa scale
Time Frame: Day of procedure
|
Colonoscopy was performed by gastroenterology fellows under the supervision of attending physicians and both were blinded to the type of preparation taken by the study patients.
Bowel cleansing was evaluated by the Ottawa scale.
Scoring of each part of the colon (right, middle and left) was done separately and the total amount of fluid was noted.
The scores were then added to calculate the total score out of 14.
|
Day of procedure
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Patient compliance
Time Frame: Day of procedure
|
Before the patients were taken to the endoscopy suite, they completed a questionnaire, asking the amount of preparation that was taken to evaluate compliance.
|
Day of procedure
|
Patient tolerance
Time Frame: Same day
|
Before the patients were taken to the endoscopy suite, they completed a questionnaire to evaluate tolerance for taking the preparation.
Patients were asked about side-effects like nausea, vomiting, abdominal pain and bloating.
|
Same day
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Bashar Attar, MD, PhD, Cook County Health & Hospitals System
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2012
Primary Completion (Actual)
November 1, 2012
Study Completion (Actual)
December 1, 2012
Study Registration Dates
First Submitted
January 7, 2013
First Submitted That Met QC Criteria
January 8, 2013
First Posted (Estimated)
January 10, 2013
Study Record Updates
Last Update Posted (Estimated)
June 16, 2023
Last Update Submitted That Met QC Criteria
June 14, 2023
Last Verified
June 1, 2023
More Information
Terms related to this study
Other Study ID Numbers
- 11-206
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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