- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01799148
Air Pollution, Inflammation and Acute Coronary Syndrome (AIRACOS)
January 19, 2015 updated by: Alberto Domínguez Rodríguez, Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Impact of AIR Pollution on Inflammation, Oxidative Stress and 1-year Prognosis in Patients Hospitalized for Acute COronary Syndrome
The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of inflammatory molecules and oxidative stress.
2) To investigate whether the level of environmental exposure is an independent prognostic factor in terms of overall and cardiovascular mortality, myocardial infarction or unstable angina at 30 days, 6 and 12 months.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Observational
Enrollment (Actual)
307
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Santa Cruz de Tenerife
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La Laguna, Santa Cruz de Tenerife, Spain, E-38320
- Hospital Universitario de Canarias
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 85 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Cohort of consecutive patients admitted with diagnosis of aucte coronary, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission.
Also be determined inflammatory molecules and oxidative stress in admission.
During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events.
It also will quantify the exposure of air pollutant particles, in all patients included at 30 days, 6 and 12 months.
Description
Inclusion Criteria:
- Patients with acute coronary syndrome
Exclusion Criteria:
- Infectious process and / or local or systemic inflammation in the 15 days before admission.
- Thyrotoxicosis.
- Neoplasms - or any other disease that seriously compromise the prognosis of life and / or generate a systemic inflammatory response.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Particulate air pollutants
Cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission.
|
We will determined the average concentrations of different sizes of particulate matter from 1 day or up to 7 days prior to admission in patients with acute coronary syndrome.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.
Time Frame: 7 days
|
A single center, cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission.
Also be determined inflammatory molecules and oxidative stress in admission.
|
7 days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.
Time Frame: 1 year
|
During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events.
It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.
|
1 year
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome:
Time Frame: 1 year
|
During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events.
It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.
|
1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2011
Primary Completion (Actual)
July 1, 2014
Study Completion (Actual)
November 1, 2014
Study Registration Dates
First Submitted
February 23, 2013
First Submitted That Met QC Criteria
February 25, 2013
First Posted (Estimate)
February 26, 2013
Study Record Updates
Last Update Posted (Estimate)
January 21, 2015
Last Update Submitted That Met QC Criteria
January 19, 2015
Last Verified
January 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AIRACOS
- AIRACOS-CANARY ISLANDS (Other Identifier: Hospital Universitario de Canarias)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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