- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01879007
Phase I Trial for Pharmacokinetic Characteristics of Factive 200mg Intravenous Formulation (Gemifloxacin 200mg) With Factive 320mg Tablet Formulation (Gemifloxacin 320mg)
June 13, 2013 updated by: LG Life Sciences
This study seeks to compare the pharmacokinetic characteristics of Factive 200mg Intravenous Formulation (Gemifloxacin 200mg) with those of Factive 320mg Tablet Formulation (Gemifloxacin 320mg) and to explore possibility of clinical use of the IV formulation.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
16
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Seoul, Korea, Republic of
- Asan Medical Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
19 years to 45 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Healthy Korean males between 19 and 45 years of age, weighing within 15% deviation of the ideal weight (CRC criteria) and residing in Korea (Appendix 4)
- Applicants judged eligible as subject based on health exams (interview, blood pressure, 12-lead ECG, physical exam, blood and urine tests, and other screening tests) conducted not more than three weeks prior to administration (those with two or less clinically significant results)
- Applicants who can take part in the whole process of clinical study
- Applicants who sufficiently received explanation on the purpose and content of clinical study, characteristics of the investigational products, etc., before participating in the study and gave written consent to participate in the study voluntarily
Exclusion Criteria:
- Applicants who exhibit symptoms suspected to be those of acute diseases prior to the start of the study
- Clinically significant kidney disease or liver disease
- Cardiovascular, respiratory, renal, endocrine system, hematology (hemorrhagic diathresis), digestive system (peptic ulcer), central nerve system, psychiatric disorder, or malignant tumors; chronic diseases that can influence the absorption, distribution, metabolism, or excretion of drugs
- Applicants who have been on an abnormal diet, which can influence the absorption, distribution, metabolism, or excretion of drugs
- Medical history of gastrointestinal resection except appendectomy
- Applicants testing positive for hepatitis B antigen, hepatitis C antibody, or HIV antibody;
- Clinically significant allergic diseases (excluding mild allergic rhinitis that does not require medication)
- Known history of hypersensitivity to drugs
- Known history of developing complications such as epilepsy or other convulsive diseases
- Excessive consumption of caffeine and alcohol or heavy smoker
- History of alcohol or drug abuse
- Applicants who cannot take the standard meals provided by ASAN Medical Center(AMC)
- Donation of whole or apheresis blood prior to the administration
- Participation in other clinical study as subjects prior to the administration
- Applicants who have taken prescription drugs prior to the administration or OTC(over-the-counter) drugs prior to the administration and for which such medications are judged by the principal investigator to have an influence on this study or on the safety of the subject
- Applicants who are highly likely to take other medication during the study
- Applicants who took medication that induces or inhibits drug-metabolizing enzymes such as barbiturates or consumed excessive amounts of alcohol less than 1 month prior to the administration
- Medical history of meningitis, encephalitis, or brain injury
- Difficulty in cooperating with researchers in proceeding with the study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: group 1
received one intravenous administration and one oral medication with interval of 1 week,
|
|
Experimental: group 2
received one oral administration and one intravenous medication with interval of 1 week
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
AUC
Time Frame: Up to 48 hr
|
Up to 48 hr
|
Cmax
Time Frame: Up to 48 hr
|
Up to 48 hr
|
Tmax
Time Frame: Up to 48 hr
|
Up to 48 hr
|
MRT
Time Frame: Up to 48 hr
|
Up to 48 hr
|
CL
Time Frame: Up to 48 hr
|
Up to 48 hr
|
Vss
Time Frame: Up to 48 hr
|
Up to 48 hr
|
F
Time Frame: Up to 48 hr
|
Up to 48 hr
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2006
Primary Completion (Actual)
March 1, 2006
Study Registration Dates
First Submitted
June 4, 2013
First Submitted That Met QC Criteria
June 13, 2013
First Posted (Estimate)
June 17, 2013
Study Record Updates
Last Update Posted (Estimate)
June 17, 2013
Last Update Submitted That Met QC Criteria
June 13, 2013
Last Verified
June 1, 2013
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LG-AACL006
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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