- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01950962
Role Of Phospholipid Transfer Proteins (Pltp) On Endotoxemia Caused By Buccal Inflammation (TOXIB)
July 26, 2019 updated by: Centre Hospitalier Universitaire Dijon
ROLE OF PHOSPHOLIPID TRANSFER PROTEINS (PLTP) ON ENDOTOXEMIA CAUSED BY BUCCAL INFLAMMATION
This is a transversal double-centre study.
Patients will be recruited from outpatient consultations.
They will have buccal inflammation caused by periodontal disease (frequent oral infections, mostly with GRAM (-) bacteria).
Three groups of 80 patients, corresponding to slight, moderate and severe periodontal disease, will be formed according to the results of radiological and clinical examinations.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
242
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Dijon, France, 21000
- CHU Dijon
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
35 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Pre-Inclusion criteria:
- Persons aged from 35 to 80 years old
- Persons who have provided written informed consent
- Patients with periodontal disease whatever the severity with at least one molar or one premolar on the dental arch
- Possibility to examine the oral cavity (patient able to open mouth)
- Possibility to do an orthopantomogram (sitting position required and patient able to clench jaws)
- Patient able to understand French
- Patient who accepts to provide fasting blood sample within the five days following the initial consultation
DEFINITIVE INCLUSION CRITERIA
- Patient present for the fasting blood sample within five days following the initial consultation Patients will be matched for sex and, as much as possible, for age in the three groups and for the severity of the periodontal disease
Exclusion Criteria:
- Persons not covered by the national health insurance agency
- Patients with a high risk of infectious endocarditis who require prophylaxis for any medical act involving blood
- Patients who have taken at least once during the 8 days preceding the definitive inclusion an anti-inflammatory dose of NSAIDS and/or a salicylate (blood sample)
- Patients who have had long-term treatment (>6 months) with corticoids at a dose of at least 15 mg per day
- Patients on antibiotics less than 15 days before the blood sample
- Patients with oral inflammation requiring treatment with antibiotics or anti-inflammatory drugs during the pre-inclusion
- Scaling during the 24 hours before the blood sample
- History of oral cancer or cancer of the pharynx
- Active cancer (patient undergoing treatment or diagnosis within the previous 5 years)
- Iatrogenic, spontaneous or therapeutic immunodepression (patient on immunosuppressants or antiretrovirals),
Systemic or organ specific inflammatory syndrome not related to the periodontal disease
- proven bacterial, viral or fungal Infection either developing or being treated (urinary, prostate infection)
- Inflammatory cancer (solid tumour, malignant hemopathy)
- Pregnancy
- Impossibility to cooperate due to a psychiatric disease, dementia
- Patients unable to understand the protocol
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: slight periodontal disease
|
|
Other: moderate periodontal disease
|
|
Other: severe periodontal disease
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Score of severity of oral inflammation
Time Frame: up to 5 days
|
up to 5 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 14, 2010
Primary Completion (Actual)
June 12, 2014
Study Registration Dates
First Submitted
August 27, 2013
First Submitted That Met QC Criteria
September 23, 2013
First Posted (Estimate)
September 26, 2013
Study Record Updates
Last Update Posted (Actual)
July 30, 2019
Last Update Submitted That Met QC Criteria
July 26, 2019
Last Verified
July 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Lafon PHRC IR 2010
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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