- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01958229
Efficacy Study of Telbivudine in Chronic Hepatitis B Patients
A Multicenter Open-label, Observational Study of Telbivudine Treatment Outcome in Patients With Chronic B Virus Infection
Study Overview
Status
Detailed Description
This study will be multicenter, open-label and observational data collection of patients on telbivudine who meet baseline characteristics defined as the majority of patients seen in the clinic setting. Data collection will take place after enrollment, at Week 12, 24, 52, 76 and 104 for efficacy assessments. In patients who discontinue observational drug earlier, clinical information would be kept following for assessment as well.
Study purpose:
This study is designed to evaluate the efficacy of telbivudine in real-life clinical settings with the use of the Roadmap Concept in chronic hepatitis B treatment.
Objectives:
Primary:
To observe telbivudine's 2-year efficacy in real-world clinical setting of achieving HBV-DNA < 60 IU/ml and HBeAg seroconversion rate in patients with defined baseline characteristics and 24-week treatment PCR negativity as previously reported in GLOBE study's sub-analysis.
Secondary:
- To observe the treatment outcomes.
- To validate the result of super-responder trial.
- To validate the Roadmap Concept.
Population:
The study population will consist of a representative group of 500 chronic hepatitis B patients with detectable HBsAg for more than 6 months who need telbivudine therapy based on investigators' judgment in 16 medical centers located in Taiwan.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
-
Taipei City, Taiwan, 100
- National Taiwan University Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Male or female 18 to 65 years of age
Documented chronic hepatitis B defined by ALL of following:
- Clinical history compatible with compensated chronic hepatitis B
- Detectable serum hepatitis B surface antigen (HBsAg)> 6 months and at the screening visit.
Exclusion Criteria:
- Pregnant or nursing
- co-infection with hepatitis C virus (HCV) or HIV
- Clinical or imaging diagnosis of cirrhosis
- Evidence of decreased renal function of creatinine >(=)2x ULN
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
CHB patients without cirrhosis
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
PCR negativity
Time Frame: week 52
|
week 52
|
HBeAg seroconversion rate
Time Frame: week 52
|
week 52
|
PCR negativity
Time Frame: week 104
|
week 104
|
HBeAg seroconversion rate
Time Frame: week 104
|
week 104
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Rate of ALT normalization
Time Frame: week 52
|
week 52
|
Genotypic resistance
Time Frame: week 52
|
week 52
|
Rate of ALT normalization
Time Frame: week 104
|
week 104
|
Genotypic resistance
Time Frame: week 104
|
week 104
|
Collaborators and Investigators
Investigators
- Principal Investigator: Jia-Horng Kao, Professor, National Taiwan University Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Digestive System Diseases
- RNA Virus Infections
- Virus Diseases
- Infections
- Blood-Borne Infections
- Communicable Diseases
- Liver Diseases
- Hepatitis, Viral, Human
- Hepadnaviridae Infections
- DNA Virus Infections
- Enterovirus Infections
- Picornaviridae Infections
- Hepatitis B
- Hepatitis
- Hepatitis A
- Hepatitis B, Chronic
- Hepatitis, Chronic
Other Study ID Numbers
- 200910027M
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Chronic Hepatitis B
-
The Affiliated Nanjing Drum Tower Hospital of Nanjing...Gilead SciencesNot yet recruiting
-
Tongji HospitalGilead SciencesRecruiting
-
Jiangsu HengRui Medicine Co., Ltd.Unknown
-
Changhai HospitalCompleted
-
Tongji HospitalChia Tai Tianqing Pharmaceutical Group Co., Ltd.UnknownChronic Hepatitis b
-
Zhongshan Hospital Xiamen UniversityUnknownHealthy | Chronic Hepatitis B InfectionChina
-
Brii Biosciences LimitedVir Biotechnology, Inc.Active, not recruitingChronic Hepatitis B Virus InfectionSingapore, Thailand, Australia, China, Korea, Republic of
-
Nanfang Hospital of Southern Medical UniversityRecruiting
-
IlDong Pharmaceutical Co LtdRecruitingChronic Hepatitis bKorea, Republic of