- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02136719
Bimanual Uterine Compression to Reduce Blood Loss and Prevent Postpartum Haemorrhage After Vaginal Delivery
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
the investigators conduct a prospective non- randomized study at Department of Obstetrics and Gynecology, Benha University Hospital, since April 2014 till May 2016, after approval of the study protocol by the Local Ethical Committee. A written informed consent is obtained from eligible women before induction or at early stage of labour.
Women with singleton pregnancies of more than 28 weeks' gestation who are admitted to hospital and candidates for vaginal delivery are eligible for the study .Gestational age more than 28 weeks the gestational age is determined based upon the date of the first day of last normal menstrual period and confirmed by ultrasound scan during the 1st trimester.
The patients (520) are divided into two groups, Group A (260) receive bimanual uterine compression immediately after delivery of the placenta for 5 minutes while Group B (260) receive no intervention.
The third stage of labour was managed as usual by clamping and cutting of umbilical cord, waiting for signs of placental separation and delivering the placenta by controlled cord traction.
Duration of the 3rd stage of labour is calculated. Patients are kept in labor room under observation for a period of 1 h.
Measurement of blood loss by a clean plastic lined absorbent drape placed under the woman's buttocks to collect all the blood lost after delivery of the baby and drainage of the amniotic fluid. The drape is changed as many times as needed. The woman stays on the drape or asked to wear a pad over the next 60 minutes. In the case of severe haemorrhage, the investigators follow the usual guidelines for management of postpartum haemorrhage, and the supplemental treatment registered. All drapes and pads are weighed on an electronic scale and the known dry weight of the linen is subtracted. As 1 ml of blood weighs close to 1 g, the balance in grams is assumed to be the total blood loss in ml.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
El Qualyobia
-
Banhā, El Qualyobia, Egypt, 13518
- Recruiting
- Benha univesity hospital and afhsa
-
Principal Investigator:
- ibrahim zweel, MD
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Gestational age more than 28 weeks the gestational age was determined based upon the date of the first day of last normal menstrual period and confirmed by ultrasound scan during the 1st trimester
Women at high risk for primary atonic postpartum hemorrhage
- Over distended uterus
- Large fetus
- Multiple fetuses
- Hydramnios
- Distension with clots accidental hemorrhage
- Exhausted myometrium
- Prolonged labor
- Oxytocin or prostaglandin stimulation
- Chorioamnionitis
- Previous uterine atony
- Placenta previa
- Marked anemia
Exclusion Criteria:
- Cervical tear
- extensive birth canal tear
- Postpartum hemorrhage
- Retained placenta
- Coagulopathy
- Chronic medical illness hepatic renal
- Pregnancy induced hypertension PIH
- Refusal to participate in the study
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Group A
bimanual uterine compression immediately after delivery of placenta for 5 minutes in 260 women
|
bimanual uterine compression immediately after delivery of placenta for 5 minutes
|
No Intervention: Group B
no intervention (260 women).
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Blood loss 500 ml or more after enrolment
Time Frame: 60 minutes after enrolment
|
estimating blood loss from vagina
|
60 minutes after enrolment
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Blood loss 1000 ml or more after enrolment
Time Frame: (up to 30 and 60 minutes) after enrolment
|
estimating blood loss by collecting it
|
(up to 30 and 60 minutes) after enrolment
|
Use of additional uterotonics or other procedures
Time Frame: 60 minutes
|
giving drugs IV
|
60 minutes
|
Blood transfusion
Time Frame: 60 minutes
|
giving how many units of PRBCS
|
60 minutes
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: ibrahim zweel, Department of Obstetrics and Gynecology,AFHSA
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- khalidkhader 2
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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