- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02164162
Efficacy of a Robotic-assisted Gait Training in Addition to a Conventional Physical Therapy in Parkinson's Disease
Interventional Double Blinded Randomized and Controlled Trial on the Efficacy of a Robotic-assisted Gait Training in Addition to a Conventional Physical Therapy in Parkinson's Disease
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Bergamo
-
Ciserano, Bergamo, Italy, 24040
- Recruiting
- Casa di Cura Habilita
-
Principal Investigator:
- Giovanni Taveggia, MD
-
Contact:
- Paola Sabattini, Coordinator
- Phone Number: 507 +390354815
- Email: paolasabattini@habilita.it
-
Sub-Investigator:
- Anna Furnari, MD
-
Sub-Investigator:
- Anna Furnari
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Parkinson's disease stage 2 to 3 (calculated in the "on phase") on the Hoehn and Yahr scale
- independent walking
- clinical-pharmacological stabilization until three months before the beginning of the study.
Exclusion Criteria:
- deficits of somatic sensation involving the legs
- vestibular disorders or paroxysmal vertigo
- other neurological, orthopedic or cardiovascular co-morbility
- severe posture abnormalities
- severe-moderate cognitive impairment (Minmental state ≤ 21)
- severe dyskinesia or "on-off"phases
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Experimental group
Participants received 12 sessions of robotic assisted body weight-supported treadmill training on the Lokomat. Training occurred approximately 3 days/ week for 4 weeks, and each training session on the Lokomat lasted 30 minutes. All sessions were supervised by a trained research therapist. All participants started with 40% body weight-support and an initial treadmill speed of 1.5 km/h. Body weight-support was used primarily to facilitate an increase in walking speed; therefore, progression of training across subsequent sessions was standardized by preferentially increasing speed and then unloading body weight-support. Speed was increased to a range of 2.2 to 2.5 km/h before body weight-support was decreased. There was an active attempt to enhance the level of training at each session. |
Patients allocated to the Experimental group performed a Robotic Assistested Gait Training by means of the Lokomat.
The Lokomat is robotic device set up as an exoskeleton on the lower limbs of the patient.
The system uses a dynamic body weight-support system to support he participant above a motorized treadmill synchronized with the Lokomat.
|
Active Comparator: Control group
Participants received 20 sessions of conventional physiotherapy.
Training occurred approximately 5 days/week for 4 weeks, and each training session lasted 1 hour .Patients allocated to the Control Group performed a general exercise program and a conventional gait training with a 5-minute rest between them.
The general exercise program consisted in cardiovascular warm-up exercises, muscle stretching exercises, active-assisted or active isometric and isotonic exercises for the main muscles of the trunk and limbs, relaxation exercises, coordination and dual task activities and balance exercises.
The conventional gait therapy was based on the proprioceptive neuromuscular facilitation concept (lasting 30 minutes), with rhythmic initiation, slow reversal, and agonistic reversal exercises applied to the pelvic region, each 10 minutes long.
|
Patients allocated to the Control Group performed a general exercise program and a conventional gait training.
The general exercise program consisted in cardiovascular warm-up exercises, muscle stretching exercises, active-assisted or active isometric and isotonic exercises for the main muscles of the trunk and limbs, relaxation exercises, coordination and dual task activities and balance exercises.
The conventional gait therapy was based on the proprioceptive neuromuscular facilitation (PNF) concept (lasting 30 minutes), with rhythmic initiation, slow reversal, and agonistic reversal exercises applied to the pelvic region, each 10 minutes long.
The same trained therapist treated all the patients in this group and standardized the duration of each part of the treatment.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Timed 6 meter walking test
Time Frame: 4 weeks
|
Timed 6-meter walking test evaluate the gait speed.
Individual walks without assistance 10 meters and the time is measured for the intermediate 6 meters to allow for acceleration and deceleration
|
4 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Movement Disorder Society-Unified Parkinson's Disease Rating Scale Disease rating scale motor sub-scores)
Time Frame: 4 weeks
|
a scale to assess the motor specific examination for Parkinson's Disease
|
4 weeks
|
Functional Independence Measure
Time Frame: 4 weeks
|
to assess daily activities functional autonomy
|
4 weeks
|
Barthel Index
Time Frame: 4 weeks
|
to assess the degree of disability
|
4 weeks
|
Tinetti Test
Time Frame: 4 weeks
|
to assess balance and gait ability and the falls risk
|
4 weeks
|
Parkinson's Disease Questionnaire -39 item
Time Frame: 4 weeks
|
to assess quality of life
|
4 weeks
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- RAR06
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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