- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02272959
Attention Bias Modification Treatment (ABMT) for Anxiety Disorders in Youth Who do Not Respond to CBT
September 16, 2018 updated by: Yair Bar-Haim
Attention Bias Modification Treatment for Children With Anxiety Disorders Who do Not Respond to Cognitive Behavioral Therapy: A Randomized Controlled Trial
First-line psychosocial treatments for anxiety disorders in children are largely exposure-based cognitive behavioral therapies (CBTs).
Despite strong evidence supporting CBT's efficacy, for up to 50% of youth patients, symptoms of anxiety persist after a full course of treatment.
What are the treatment options for these youth?
Unfortunately, there is not a single empirical study in the youth anxiety treatment literature that has systematically examined treatment augmentation for youth who fail to respond to CBT.
Empirical efforts to address this issue are important because youth who do not respond to CBT continue to suffer emotional distress and impairment associated with anxiety disorders.
This study will address this gap via double-blind randomized controlled trial of Attention Bias Modification Treatment (ABMT) for anxious 10-18 year-olds who did not respond to standard CBT.
Attention biases in threat processing have been assigned a prominent role in the etiology and maintenance of anxiety disorders.
ABMT utilizes computer-based protocols to implicitly modify biased attentional patterns in anxious patients.
Here, participants will be CBT non-responders who will be assessed by using clinical interviews and parent- and self-rated questionnaires before and after eight sessions of ABMT or placebo control, and again at an eight-week follow-up.
We expect to see reduction in anxiety symptoms in the Attention Bias Modification Treatment (ABMT) group relative to the placebo control group.
We also expect the findings to inform pathways to treatments for anxious children who do not respond to current standard first-line therapy, and to provide initial information on mechanisms of ABMT efficacy.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
100
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Yair Bar-Haim, Prof.
- Phone Number: 972-3-6405465
- Email: yair1@post.tau.ac.il
Study Contact Backup
- Name: Marian Linetzky, M.A.
- Phone Number: 972-54-4947028
- Email: marian.linetzky@gmail.com
Study Locations
-
-
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Tel-Aviv, Israel
- Recruiting
- Tel-Aviv University
-
Principal Investigator:
- Yair Bar-Haim, PhD
-
Contact:
- Yair Bar-Haim, PhD
- Email: yair1@post.tau.ac.il
-
Contact:
- Marian Linetzky
- Email: marian.linetzky@gmail.com
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Sub-Investigator:
- Marian Linetzky
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
10 years to 18 years (Child, Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
To be included all youth must:
- have received a full course of CBT and were deemed treatment non-responders.
- they must still have a primary diagnosis of GAD, SOP, or SAD.
- if they have comorbid attention deficit hyperactivity disorder (ADHD) or depressive disorders, it must be treated with medication and stable.
- if they have tics or impulse control problems, those problems must be treated with medication and stable and cause minimal or no impairment.
Exclusion Criteria: To be excluded youth must:
- meet diagnostic criteria for Organic Mental Disorders, Psychotic Disorders, Pervasive Developmental Disorders, or Mental Retardation.
- show high likelihood of hurting themselves or others.
- have not been living with a primary caregiver who is legally able to give consent for the child's participation.
- be a victim of previously undisclosed abuse requiring investigation or ongoing supervision.
- be involved currently in another psychosocial treatment.
- have a serious vision problem that is not corrected with prescription lenses.
- have a physical disability that interferes with their ability to click a mouse button rapidly and repeatedly.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Attention Bias Modification treatment (ABMT)
Attention training via repeated trials of a dot-probe task intended to direct attention away from threat stimuli using threat and neutral stimuli.
|
Attention training using a computerized spatial attention task (dot-probe) modified to alter threat-related attention patterns using threat and neutral stimuli.
|
Placebo Comparator: Placebo Group
Attention training via repeated trials of a dot-probe task not intended to change threat-related attention patterns using only neutral stimuli.
|
Attention training using a computerized spatial attention task (dot-probe) not intended to alter threat-related attention patterns using only neutral stimuli.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The Pediatric Anxiety Rating Scale (PARS)
Time Frame: expected average time frame of 6 weeks.
|
The PARS assesses global anxiety severity across different anxiety disorders in youth.
|
expected average time frame of 6 weeks.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Anxiety Related Emotional Disorders - Child/Parent Version (SCARED-C/P)
Time Frame: expected average time frame of 6 weeks.
|
The SCARED is a 41-item self and parent-report instrument designed to assess anxiety in children and adolescents. Screen for Child |
expected average time frame of 6 weeks.
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2015
Primary Completion (Anticipated)
July 1, 2019
Study Completion (Anticipated)
July 1, 2019
Study Registration Dates
First Submitted
October 21, 2014
First Submitted That Met QC Criteria
October 22, 2014
First Posted (Estimate)
October 23, 2014
Study Record Updates
Last Update Posted (Actual)
September 18, 2018
Last Update Submitted That Met QC Criteria
September 16, 2018
Last Verified
September 1, 2018
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- loe140498ctil
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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