Study of Gemcitabine+Platinum Salt+Bevacizumab Combination for Metastatic Collecting Duct Carcinoma (GETUG-AFU 24) (BEVABEL)

Prospective Phase II Study of Gemcitabine Plus Platinum Salt in Combination With Bevacizumab (Avastin®) for Metastatic Collecting Duct Carcinoma

Open-label, non-randomized, multicenter, phase II, single arm non comparative trial evaluating toxicity and efficacy of gemcitabine plus platinum salt in combination with bevacizumab in first-line setting in metastatic collecting duct carcinoma.

Study Overview

• Status: Completed
• Conditions: Collecting Duct Carcinoma (Kidney)
• Intervention / Treatment: Drug: Bevacizumab

• Study Type: Interventional
• Enrollment (Actual): 36
• Phase: Phase 2

Contacts and Locations

Study Locations

• France
  • Angers, France, 49333
    • Institut de Cancérologie de l'Ouest-Site Paul Papin
  • Besançon, France, 25030
    • CHU Besançon
  • Bordeaux, France, 33075
    • Hopital Saint André
  • Caen, France, 14076
    • Centre Francois Baclesse
  • Créteil, France, 94000
    • Hopital Henri Mondor
  • Lille, France, 59020
    • Centre Oscar Lambret
  • Lyon, France, 69008
    • Centre Leon Berard
  • Marseille, France, 13273
    • Institut Paoli-Calmettes
  • Montpellier, France, 34298
    • ICM Val D'Aurelle
  • Nice, France, 06189
    • Centre Antoine Lacassagne
  • Paris, France, 75908
    • Hopital Europeen Georges Pompidou
  • Paris, France, 75010
    • Hôpital Saint-Louis
  • Rennes, France, 35064
    • Centre Eugène Marquis
  • Rennes, France, 35042
    • Centre Eugène Marquis
  • Saint Herblain, France, 44800
    • Institut de Cancérologie de l'Ouest - Site René Gauducheau
  • Strasbourg, France, 67091
    • CHU Strasbourg - Hôpital Civil
  • Toulouse, France, 31059
    • Institut Claudius Regaud
  • Tours, France, 37044
    • CHR Bretonneau
  • Villejuif, France, 94805
    • Gustave Roussy, Cancer Campus, Grand Paris

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. Patients should be aged ≥18 years at the inclusion,
2. Patients with histologically confirmed metastatic collecting duct carcinoma (medullary accepted),
3. Available tumor samples for centralized reading by anatomopathologist,
4. Patients with or without nephrectomy,
5. At least one measurable lesion as per response evaluation criteria in solid tumors version 1.1 (RECIST v1.1),
6. No prior chemotherapy nor anti-angiogenic drugs ; Prior adjuvant chemotherapy of localised disease admitted if it is stopped for more than 12 months at the inclusion date.,
7. No irradiation within 4 weeks before inclusion,
8. Absolute neutrophil counts (ANC) ≥1.5 x 10⁹/L,
9. Platelets ≥100 x 10⁹/L,
10. Hemoglobin ≥9 g/dL,
11. Hepatic function : AST and ALT ≤1.5 x ULN (≤4 x ULN in case of liver metastases); total bilirubin ≤1.5 x ULN; alkaline phosphatase <2 x ULN (≤4 x ULN in case of bone metastases),
12. Renal function : creatinine clearance ≥60 mL/min (MDRD calculation method) using cis-platin and >30 mL/min when using carboplatin,
13. Absence of proteinuria at baseline defined by <0.3 g of protein on urine sample or <0.5 g/24h on urine collection,
14. Prothrombin time (TP) or partial thromboplastin time (PTT) strictly less than 50% deviation from normal limits, of international normalized ratio (INR) strictly below 2, Note: The use of full-dose oral or parenteral anticoagulants as well as aspirin or clopidogrel is permitted as long as the INR or a PTT is within therapeutic limits (according to the medical standard of the institution) and the patient has been on a stable dose of anticoagulants for at least two weeks at the time of study enrolment. Prophylactic use of anticoagulants is allowed.
15. ECG with normal or clinically insignificant as per investigator's judgement sinus rhythm,
16. ECOG Performance Status: 0 - 2,
17. Estimated life expectancy ≥12 weeks,
18. Patients who have received the information sheet, dated and signed the informed consent form,
19. Patient of child-bearing potential (for female patient: study entry after a menstrual period and a negative pregnancy test) must agree to use two medically acceptable methods of contraception (one for the patient and one for the partner) during the study and for 6 months after the last study treatment intake.
20. Patients must be willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures,
21. Patients affiliated to the Social Security System,

Exclusion Criteria:

1. Treatment with any other investigational agent, or participation in another clinical trial within 28 days prior to enrolment,
2. Prior systemic treatment with chemotherapy or anti-angiogenic tyrosine kinase inhibitors such as axitinib, sunitinib, sorafenib, pazopanib, tivozanib, mTOR inhibitor (Temsirolimus or everolimus) and targeted VEGF drugs such as bevacizumab and VEGF trap,
3. Evidence of current spinal cord compression or leptomeningeal disease. Please note that patients with asymptomatic brain metastases are eligible,
4. Another histological type of renal cancer
5. Other malignancy within 3 years prior to inclusion (except basal cell carcinoma of the skin and/or in situ carcinoma of the cervix, and/or pT1/a bladder cancer),
6. Uncontrolled hypertension (≥160 mm Hg systolic and/or ≥90 mm Hg diastolic) while receiving medication,
7. Cardio-vascular disorders: congestive heart failure ≥ NYHA II, myocardial infarction or coronary artery bypass graft in the previous six months, ongoing severe or unstable angina,
8. LVEF value strictly less than 50%,
9. Current or recent (within 2 weeks of study enrolment) initiation of aspirin, clopidogrel), oral or parenteral anticoagulants or thrombolytic agents for therapeutic purposes,
10. History of clinically significant hemorrhagic or thromboembolic events in the past six months, or known inherited predisposition to bleeding or thrombosis or History of abdominal fistula, GI perforation, intra-abdominal abscess or active GI bleeding within 6 months prior to the first study treatment; History of haemoptysis ≥ grade 2 (defined as ≥2.5 mL bright red blood per episode) within 1 month of study enrolment,
11. Patients who underwent, according to the investigator, a significant surgery such as but not limited to , abdominal, thoracic or neurologic surgery within 28 days before the first treatment administration or patient with a wound that is not already healed at the first treatment administration or patients who underwent a minor surgical procedure including placement of a vascular access device, within 2 days of the first study treatment,
12. Patients with active gastro-duodenal ulcer,
13. Patients with untreated bone fracture,
14. Peripheral neuropathy grade ≥2 (Toxicity Criteria-(CTCAE) v4.0),
15. Patients with active infection requiring intravenous antibiotics at the time of first study treatment,
16. In the opinion of the investigator, any evidence of other severe or uncontrolled systemic disease (e.g. unstable or uncompensated respiratory, cardiac, hepatic or renal disease), or any other acute or chronic medical condition that would make the patient inappropriate with this study,
17. Immunocompromised patients, including known seropositivity for human immunodeficiency virus (HIV),
18. Known hypersensitivity to any component of the investigational drugs or excipients,
19. Pregnant or lactating women,
20. Person deprived of their liberty or under judicial protection (including guardianship),
21. Patients with significantly altered mental status prohibiting the understanding of the study or with psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule or any condition which, in the opinion of the investigator, would preclude participation in this trial. Those conditions should be discussed with the patient before registration in the trial.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: NA
• Interventional Model: SINGLE_GROUP
• Masking: NONE

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: 1; Patients will be treated for a maximum of 6 (21 days) chemotherapy cycles (Gemcitabine+platinum salt+bevacizumab)	Drug: Bevacizumab; Patients will be treated for a maximum of 6 (21days) chemotherapy cycles (Gemcitabine+platinum salt+bevacizumab). In case of disease control (complete, partial or stable disease) treatment with bevacizumab 15 mg/Kg monotherapy every 21 days will be continued until disease progression or until the end of the 24 months of follow-up.; Other Names: Avastin

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Composite endpoint : Objective response rate / Progression-free survival	The primary endpoint is composed of: the objective response rate (CR or PR) according to RECIST criteria (V1.1) on the basis of measurable lesions defined at baseline,; the progression-free survival (PFS) rate at 6 months , PFS is defined as the absence of disease progression or death	6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Progression-free survival (PFS)	Progression-free survival (PFS) will be calculated from the date of the first dose of treatment to the date of progression or death (whichever comes first), or last date with no progression	2 years max
The Overall Survival (OS)	The Overall Survival (OS) will be calculated from the date of the first dose of treatment to the date of death (whatever the cause) or the date of last follow-up	2 years max
The toxicity will be evaluated according to the NCI-CTC scale version 4.0		2 years max

Collaborators and Investigators

• Sponsor: UNICANCER
• Investigators: Principal Investigator: Constance THIBAULT, Dr, Hopital Europeen Georges-Pompidou; Study Chair: Marc-Olivier TIMSIT, Dr, Hopital Europeen Georges-Pompidou

Study record dates

Study Major Dates

• Study Start: December 1, 2014
• Primary Completion (ACTUAL): March 1, 2020
• Study Completion (ACTUAL): August 1, 2020

Study Registration Dates

• First Submitted: February 9, 2015
• First Submitted That Met QC Criteria: February 13, 2015
• First Posted (ESTIMATE): February 16, 2015

Study Record Updates

• Last Update Posted (ACTUAL): March 9, 2021
• Last Update Submitted That Met QC Criteria: March 4, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: Bevacizumab; Metastatic; Chemotherapy; Bellini
• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Kidney Diseases; Urologic Diseases; Adenocarcinoma; Neoplasms, Glandular and Epithelial; Kidney Neoplasms; Neoplasms, Ductal, Lobular, and Medullary; Carcinoma, Renal Cell; Carcinoma; Carcinoma, Ductal; Physiological Effects of Drugs; Antineoplastic Agents; Antineoplastic Agents, Immunological; Angiogenesis Inhibitors; Angiogenesis Modulating Agents; Growth Substances; Growth Inhibitors; Bevacizumab
• Other Study ID Numbers: UC-0160/1210; 2013-001179-19 (EUDRACT_NUMBER)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No