Sequelae of Developmental Dysplasia of the Hip

Structural and Functional Sequelae of Developmental Dysplasia of the Hip

The aim of this study is to assess long term effects of developmental dysplasia of the hip (DDH) to overall health and quality of life later in life. We compare hip radiographs, hip symptoms, clinical examination, head asymmetry, dental examination and intraoral scans of 170 children and young adults treated for DDH in their childhood with age and sex matched controls.

Study Overview

• Status: Active, not recruiting
• Conditions: Hip Dysplasia; Developmental Dysplasia of the Hip

Detailed Description

Developmental dysplasia of the hip (DDH) is the most common musculoskeletal disorder in infancy. However there are few reports of long term effects of successfully treated DDH. Incidence of DDH in neonatal period is approximately 1-10/1000 depending on screening protocols used, the age of the infant during screening and which ultrasonographic findings are considered normal and which DDH. The prevalence of hip dysplasia in adult population is grossly 4 % when using Wibergs Centre-Edge (CE) ≤ 20° as definition of dysplasia. It is still unclear, what is the relation between adult acetabular dysplasia and developmental dysplasia in children. Hip dysplasia overall is a major contributing factor in hip osteoarthrosis and total hip replacement in young adults.

The aim of this study is to assess long term effects of developmental dysplasia of the hip to overall health and quality of life later in life. We compare hip radiographs, hip symptoms, clinical examination, head asymmetry, dental examination and intraoral scans of 170 children and young adults treated for DDH in their early childhood with age and sex matched controls.

• Study Type: Observational
• Enrollment (Estimated): 340

Contacts and Locations

Study Locations

• Finland
  • Oulu, Finland, 90100
    • University of Oulu; Oulu University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 10 years to 30 years (Child, Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

10-30 years old patientstreated for DDH in early childhood in Oulu University Hospital

Description

Inclusion Criteria for person treated for DDH:

• DDH has been diagnosed by clinical examination, ultrasound examination or by radiological examination and treatment begun before age of 1,5 years.
• Treated in Oulu University Hospital

Exclusion Criteria:

• neurological or developmental condition which can influence hip development such as cerebral palsy or spina bifida
• other significant congenital anomalies of musculoskeletal system such as club feet

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Treated for DDH in childhood; Subjects have had DDH in childhood. DDH has been diagnosed before age of 1,5 years and treated for.
Control; Age an sex matched controls of DDH patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Wibergs Centre-Edge Angle	angle degree	10 - 30 years after DDH has been treated

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The Copenhagen Hip and Groin Outcome Score (HAGOS)	score in numbers	10 - 30 years after DDH has been treated
Oral Heath Impact Profile	Oral Heath Impact Profile (OHIP-14) -questionaire to assess Oral Health-related Quality of Life	10 - 30 years after DDH has been treated
Occlusal asymmetries	Determined by dental examination and intraoral scan	10 - 30 years after DDH has been treated
Presence of facial asymmetry	Determined by 3D -photogrammetric images	10 - 30 years after DDH has been treated

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hip deformity	Determined by hip radiograph	10 - 30 years after DDH has been treated
Asymmetry in clinical hip examination	Determined by clinical hip examination	10 - 30 years after DDH has been treated

Collaborators and Investigators

• Sponsor: University of Oulu
• Investigators: Principal Investigator: Juhana Leppilahti, Professor, University of Oulu; Study Director: Marita Valkama, Ph.D., M.D, University of Oulu, Oulu University Hospital, MRC Oulu; Study Director: Virpi Harila, Ph.D., University of Oulu, MRC Oulu

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2016
• Primary Completion (Actual): December 1, 2022
• Study Completion (Estimated): December 1, 2026

Study Registration Dates

• First Submitted: April 20, 2015
• First Submitted That Met QC Criteria: April 27, 2015
• First Posted (Estimated): May 1, 2015

Study Record Updates

• Last Update Posted (Actual): November 29, 2023
• Last Update Submitted That Met QC Criteria: November 27, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: Developmental dysplasia of the hip; Hip dysplasia; Occlusal defect
• Additional Relevant MeSH Terms: Pathologic Processes; Wounds and Injuries; Congenital Abnormalities; Joint Diseases; Musculoskeletal Diseases; Hip Injuries; Musculoskeletal Abnormalities; Joint Dislocations; Hyperplasia; Hip Dislocation; Developmental Dysplasia of the Hip; Hip Dislocation, Congenital
• Other Study ID Numbers: EETTMK:94/2014

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No