- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02474953
A Study to Compare the Pharmacokinetic Profile of a Proprietary Curcumin Forumulation to a Comparator Curcumin Product (15PCHB)
A Randomized, Double-blind, Crossover Study to Compare the Pharmacokinetic Profile of a Proprietary Curcumin Formulation to a Comparator Curcumin Product
Study Overview
Status
Conditions
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
Ontario
-
London, Ontario, Canada, N6A 5R8
- KGK Synergize Inc.
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Male and females 18-45 years of age
If female, subject is not of child bearing potential, which is defined as females who have had a hysterectomy or oophorectomy, bilateral tubal ligation or are post-menopausal (natural or surgically with > 1 year since last menstruation) OR
Females of childbearing potential must agree to use a medically approved method of birth control and have a negative urine pregnancy test result. Acceptable methods of birth control include:
- Hormonal contraceptives including oral contraceptives, hormone birth control patch (Ortho Evra), vaginal contraceptive ring (NuvaRing), injectable contraceptives (Depo-Provera, Lunelle), or hormone implant (Norplant System)
- Double-barrier method
- Non-hormonal intrauterine devices
- Vasectomy of partner
- BMI 18-29.9 kg/m2 (±1 kg/m2)
- Healthy as determined by laboratory results and medical history
- Agrees to maintain current level of physical activity throughout the study
- Agree to avoid using black or white pepper, turmeric, curcumin or curry in the preparation of food for 7 days prior to randomization and throughout the study period.
- Agree to avoid Indian and Thai cuisines for the period of the study
- Agree to avoid food with yellow dye #E100
- Agrees to avoid alcohol, caffeine 12 hours and grapefruit and grapefruit juice 48 hours prior to baseline and each subsequent clinic visit
- Agrees to consume only low polyphenols in the diet (nutritionists will counsel on high polyphenol fruits, vegetables to avoid, wine, beer, supplements, herbal extracts, and whole-grain based foods) 3 days prior to baseline and on test days (meal options and lists of foods to avoid will be provided to subjects by nutritionists)
- Has given voluntary, written, informed consent to participate in the study
Exclusion Criteria:
- BMI ≥ 30 kg/m2
- Women who are pregnant, breastfeeding, or planning to become pregnant during the course of the trial.
- Unstable medical conditions as determined by the Qualified Investigator
- Use of natural health products containing turmeric or curcumin within 7 days prior to randomization and during the course of the study
- Use of St Johns Wort 3 weeks prior to baseline and during the study
- Subjects who are smokers
- Subjects with current or history of gastrointestinal problems or disease
- Metabolic, endocrine, or chronic diseases
- Immunocompromised individuals such as subjects that have undergone organ transplantation or subjects diagnosed with human immunodeficiency virus (HIV)
- Clinically significant abnormal lab results at screening (e.g. AST and/or ALT > 2 x ULN, and/or bilirubin > 2 x ULN) will be assessed by the Qualified Investigator
- Subjects who have planned surgery during the course of the trial
- History of or current diagnosis of any cancer (except for successfully treated basal cell carcinoma) diagnosed less than 5 years prior to screening. Subjects with cancer in full remission more than 5 years of diagnosis are acceptable.
- History of gallbladder issues, hyperacidity, gastric/duodenal ulcers.
- Prior use of prescription H2 blocker, proton pump inhibitor or blood sugar-lowering agents
- Use of blood pressure medication
- Subjects on restrictive dietary regimens
- Blood donation in the last 2 months
- History of blood/bleeding disorders or taking prescription blood thinners or anti-platelet therapy
- Alcohol abuse (>2 standard alcoholic drinks per day) or drug abuse within the past 6 months
- Use of medical marijuana
- Clinically significant abnormal laboratory results at screening
- Participation in a clinical research trial within 30 days prior to randomization
- Allergy or sensitivity to study supplement ingredients or to any food or beverage provided during the study
- Individuals who are cognitively impaired and/or who are unable to give informed consent
- Any other condition which in the Investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Dosing Sequence 1
Proprietary Curcumin Formulation administered first, Unformulated Comparator Curcumin Product administered second
|
|
Experimental: Dosing Sequence 2
Unformulated Comparator Curcumin Product administered first, Proprietary Curcumin Formulation administered second
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Curcumin AUC
Time Frame: Time 0 to 48 hours
|
Area Under the Curve
|
Time 0 to 48 hours
|
Curcumin Cmax
Time Frame: Time 0 to 48 hours
|
Maximum Concentration
|
Time 0 to 48 hours
|
Curcumin Tmax
Time Frame: Time 0 to 48 hours
|
Time until maximum concentration
|
Time 0 to 48 hours
|
Other Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Incidence of adverse events
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Changes in blood CBC levels
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Changes in blood electrolyte levels
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Changes in blood creatinine levels
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Changes in blood AST levels
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Changes in blood ALT levels
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Changes in blood GGT levels
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Changes in blood bilirubin levels
Time Frame: Time 0 to 48 hours
|
Time 0 to 48 hours
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Peripheral Nervous System Agents
- Enzyme Inhibitors
- Analgesics
- Sensory System Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Antirheumatic Agents
- Antineoplastic Agents
- Curcumin
Other Study ID Numbers
- 15PCHB
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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