- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02508662
Registry Study for Personalized Cancer Therapy
Objectives:
Primary Objectives:
To evaluate the anti-cancer activity of commercially available, targeted anti-cancer therapies used off-label for treatment in patients with advanced solid cancer with known genomic aberrations.
Secondary Objectives:
To determine outcomes of patients who were treated with matched targeted anti-cancer therapies based on known genomic aberrations.
To obtain treatment related adverse events in patients with advanced solid tumor who were treated with off -label targeted therapies.
To determine co-genomic aberrations that may contribute to treatment response or resistance mechanisms.
To determine feasibility of detecting the genomic alterations in plasma, and the genomic evolution of circulating biomarkers.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Treatment Assignment:
If you are found to be eligible to take part in this study, the study doctor will review the test results in your medical records that were previously performed as part of your routine care. The results of the testing may be helpful in managing your treatment and may also help the doctor to find effective off-label use of FDA approved therapies for the type of cancer you have.
After reviewing the screening tests and the molecular test results in your medical records, the study staff and your study doctor will work together to find an off-label use for an FDA approved therapy that is best for you. You may receive a single therapy or a combination of therapies. You and the study doctor will discuss this.
The study doctor or study staff will tell you which drug(s) you will be taking, the dose of the study drug(s), and how often you should take them. You will sign a separate consent form that explains in more detail how the study drug(s) are administered and the potential benefits and side effects of taking the study drug(s).
Study Visits:
While you are receiving treatment and during follow-up, you will have your routine, standard of care clinic visits and routine tests so that the doctor may check the status of the disease to learn if the therapy chosen to treat the disease is having any effect. Information from these routine visits will be collected and stored by the study staff. The timing of these visits will depend on the type of therapy you receive.
During every cycle of therapy (about every 3-4 weeks):
- You will have a physical exam.
- Blood (about 2 teaspoons) will be drawn for routine tests.
- If your doctor thinks it is needed, urine will be collected for routine tests.
- If your doctor thinks it is needed, you will have an EKG to check the health of your heart.
After even numbered cycles (2, 4, 6, and so on), or more often if the doctor thinks is it needed, you will have the same imaging scan(s) which were done during Screening to check the status of the disease.
This is an investigational study.
Up to 100 participants will be enrolled in this study. All will take part at MD Anderson.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Texas
-
Houston, Texas, United States, 77030
- University of Texas MD Anderson Cancer Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients with advanced or metastatic cancer that is refractory to standard therapy or that has relapsed after standard therapy or has no standard therapy that increases survival by at least three months.
- Patients with a potentially actionable genomic alteration.
- All prior treatment-related toxicities must be resolved to CTCAE (Version 4.0) < or = Grade 2 (except alopecia) at the time of screening.
- Patients willing to sign informed consent.
- Patients under the age of 18 years old are allowed as long as the safety profile of the drug is established in the pediatric population.
Exclusion Criteria:
- Any serious and/or unstable pre-existing medical disorder, psychiatric disorder, or other conditions that could interfere with subject's safety, obtaining informed consent or compliance to the study procedures, in the opinion of the Investigator.
- Have a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to planned treatment drug.
- Rapidly progressing leptomeningeal or brain metastases or spinal cord compression.
- Clinical trial (including targeted and/or non-targeted) other than registry study is available; patient is willing and eligible to enroll in such trial.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Advanced Cancer (Refractory) with Genomic Mutation
Participants with advanced cancer who have exhausted standard treatment option and have no potential clinical trial available, and who have potentially actionable alterations on genomic profiling.
|
Review of screening tests and molecular test results in participant's medical records.
Study staff and study doctor work together to find an off-label use for an FDA approved therapy that is best for participant.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Tumor Response
Time Frame: 8 weeks
|
Evaluation of tumor: the same imaging technique used during the initial evaluation or more sophisticated studies performed once after 2 cycles. Patients with measurable disease assessed by standard RECIST (Version 1.1). |
8 weeks
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Funda Meric-Bernstam, MD, M.D. Anderson Cancer Center
Publications and helpful links
Helpful Links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 2015-0300
- NCI-2015-01453 (Registry Identifier: NCI CTRP)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Solid Tumors
-
Incyte CorporationRecruitingA Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid TumorsAdvanced Solid Tumors | Solid Tumors | Metastatic Solid TumorsUnited States, Spain, United Kingdom, France, Italy, Denmark, Switzerland
-
National Cancer Institute (NCI)RecruitingSolid Tumor | Refractory Solid Tumors | Malignant Solid Tumors | Other Neoplasms Solid Tumors | Pediatric Solid TumorUnited States
-
Hoffmann-La RocheCompletedSolid Tumors, Advanced Solid TumorsUnited States
-
Esperance Pharmaceuticals IncCompletedAdvanced Solid Tumors | Solid TumorsUnited States
-
Incyte Biosciences Japan GKCompletedAdvanced Solid Tumors | Metastatic Solid TumorsJapan
-
Memorial Sloan Kettering Cancer CenterKyowa Hakko Kirin Pharma, Inc.CompletedAdvanced Solid Tumors | Metastatic Solid TumorsUnited States
-
Bristol-Myers SquibbCompletedAdvanced Solid Tumors | Metastatic Solid TumorsKorea, Republic of, Canada, Australia
-
Cancer Institute and Hospital, Chinese Academy...RecruitingRefractory Solid Tumors | Relapsed Solid TumorsChina
-
Genentech, Inc.RecruitingAdvanced Solid Tumors | Metastatic Solid TumorsCanada, Korea, Republic of, United States, Brazil, Australia, Argentina, Spain, New Zealand, Poland
-
AmgenCompletedCancer | Advanced Solid Tumors | Solid Tumors | Tumors | Advanced MalignancyUnited States, Australia
Clinical Trials on Review of Screening Tests and Molecular Test Results
-
University of MiamiNational Institute on Minority Health and Health Disparities (NIMHD)CompletedHepatitis C | ColoRectal Cancer | Human Immunodeficiency Virus | Human PapillomavirusUnited States
-
The First Affiliated Hospital of University of...RecruitingEndoscopic Retrograde CholangiopancreatographyChina
-
HaEmek Medical Center, IsraelUnknownIron Deficiency | ThalassemiaIsrael
-
Agency for Healthcare Research and Quality (AHRQ)CompletedCoronary Artery Disease | Hypertension | Diabetes Mellitus | Osteoporosis | HyperlipidemiaUnited States
-
Sidney Kimmel Cancer Center at Thomas Jefferson...National Cancer Institute (NCI)UnknownColorectal CancerUnited States
-
Hillel Yaffe Medical CenterUnknownANCA-related VasculitisIsrael
-
Moscow State University of Medicine and DentistryRecruitingIrritable Bowel Syndrome | Inflammatory Bowel Diseases | Healthy VolunteersRussian Federation
-
UCSF Benioff Children's Hospital OaklandNovartis PharmaceuticalsCompletedTHALASSEMIA MAJORUnited States
-
Jonathan BaghdadiCenters for Disease Control and PreventionRecruitingPneumonia, Viral | Pneumonia | Pneumonia, BacterialUnited States