Multimodal Assessment of Sensory Processing and Brain Features in Patients With Chronic Orofacial Pain
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Chronic orofacial pain disorders may present localized in the mouth such as with persistent dentoalveolar pain disorder (PDAP) or widespread in the head/face/jaw such as with temporomandibular disorders (TMD). PDAP pain manifests in a tooth that usually underwent root canal treatment or in the site formally occupied by such tooth, while TMD pain is usually reported over the preauricular area, jaws and temples. These commonly comorbid disorders have a significant impact on the individual and society. Their mechanisms are poorly understood with evidence suggesting deficient pain modulation and abnormal brain features. PDAP and TMD patients, when compared to controls, have abnormal sensory/pain processing as well as brain structural and functional differences.
This proposal will investigate pain modulatory mechanisms and brain functional and structural characteristics using multiple MRI modalities in PDAP patients with and without TMD. All measures from patients will be compared to painfree controls. This knowledge will support better understanding of mechanisms involved in PDAP and will support development of mechanistic-based clinical treatments for the patients the investigators serve. Findings from these investigations will likely contribute to our understanding of other chronic pain conditions.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Minnesota
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Minneapolis, Minnesota, United States, 55455
- University of Minnesota School of Dentistry
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
Age- and handedness-matched painfree controls using frequency matching to maintain similar group averages:
- No self-report of persistent pain conditions for the last 6 months;
- No diagnosis of PDAP or TMD;
PDAP only:
- Fulfilling diagnostic criteria per Nixdorf et al., 20122
- Characteristic dentoalveolar PDAP pain cannot be increased by pressure provocation from jaw muscle trigger points (referred pain)
PDAP with TMD:
- Fulfilling diagnostic criteria for PDAP2 and chronic TMD myalgia per Schiffman et al. 20143
Exclusion Criteria:
Self-report:
- Chronic widespread pain
- Current use of opioids or other pain medications (e.g., ibuprofen/acetaminophen) that cannot be stopped <3 days prior to testing
- Conditions/diseases associated with altered pain perception: neurological (e.g., multiple sclerosis, trigeminal neuralgia) psychiatric disorders, diabetes, neoplasm and cardiovascular disorders
- Injury to hands
- Substance abuse
- MRI contraindications including pregnancy
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
PDAP only
Persistent dentoalveolar pain disorder patients who do not fit criteria for TMD.
Pressure pain threshold before/during conditioned pain modulation.
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Pressure algometry over thenar eminence, bilateral masseter muscles measured at baseline and during conditioned pain modulation
Other Names:
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PDAP + TMD
Persistent dentoalveolar pain disorder patients who also fit criteria for TMD.
Pressure pain threshold before/during conditioned pain modulation.
|
Pressure algometry over thenar eminence, bilateral masseter muscles measured at baseline and during conditioned pain modulation
Other Names:
|
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Painfree controls
Painfree subjects.
Pressure pain threshold before/during conditioned pain modulation.
|
Pressure algometry over thenar eminence, bilateral masseter muscles measured at baseline and during conditioned pain modulation
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Pressure pain threshold change before and during conditioned pain modulation
Time Frame: Baseline
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Pressure pain thresholds will be determined over the skin overlaying the masseter muscles bilaterally and over the right thenar eminence using a pressure algometer before and during the application of a concurrent noxious heat stimulus to the left forearm.
|
Baseline
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Estephan J Moana-Filho, DDS, MS, PhD, University of Minnesota
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pain
- Neurologic Manifestations
- Musculoskeletal Diseases
- Muscular Diseases
- Stomatognathic Diseases
- Tooth Diseases
- Jaw Diseases
- Craniomandibular Disorders
- Mandibular Diseases
- Myofascial Pain Syndromes
- Joint Diseases
- Temporomandibular Joint Disorders
- Temporomandibular Joint Dysfunction Syndrome
- Facial Pain
- Toothache
Other Study ID Numbers
- 1511M80706
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
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