Developmental Language Difficulties: Behavioural and Electrophysiological Studies (LANGAGE)

Developmental Language Difficulties: Behavioural and Electrophysiological Studies of the Connections Between Spoken and Written Language and Specificity of These Disorders

This study will help to better characterize oral and written language disorders and determine if these disorders are continuous or not. The participants ( dyslexic and dysphasic patients and control adults) will carry out an auditory lexical decision task during which an electroencephalogram (EEG) will be recorded.

Study Overview

• Status: Completed
• Conditions: Dyslexia; Dysphasia
• Intervention / Treatment: Behavioral: auditory lexical decision task; Device: electroencephalogram

• Study Type: Observational
• Enrollment (Actual): 196

Contacts and Locations

Study Locations

• Belgium
  • Louvain-la-Neuve, Belgium, 1348
    • Université catholique de Louvain (IPSY)
• France
  • Lille, France, 59000
    • Hôpital Saint Vincent de Paul (GHICL)
  • Villeneuve d'Ascq, France, 59653
    • Université de Lille 3 Charles de Gaulle (URECA)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 8 years and older (ADULT, OLDER_ADULT, CHILD)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The study population consists of 3 groups. A group of volunteers (controls), a group of patients with oral language disorders, a group of patients with written language disorders.

Description

Inclusion Criteria (patients):

• Non-verbal intelligence quotient (IQ) less than 85 according to the Wechsler Intelligence Scale for Children (WISC) perceptual index
• Specific oral language disorders diagnosed by the multidisciplinary team (neurologist, psychologist, speech therapist): understanding language deficit, estimated by the test SCOTLAND (Lecocq, 1996) and / or vocabulary test (Dunn Thiébaud).
• Specific written language disorders (dyslexia) diagnosed by a multidisciplinary team according to a test that can objectify the late reading (Alouette) and locate deficits (EVALEC)
• Be affiliated to a social security regimen
• Have signed an informed consent or signed by the parents if the patient is minor
• Aged at least 8 years old

Inclusion Criteria (controls)

• Non-deficit (>85) non-verbal Wechsler Scale (codes and matrices)
• No specific oral language disorders
• No specific written language disorders (dyslexia)
• Be affiliated to a social security regimen
• Have signed an informed consent or signed by the parents if the patient is minor
• Aged at least 8 years old

Exclusion Criteria:

• Mother tongue other than French
• Non-verbal reasoning abilities below 85 measured by the WISC 4 (for patients only) and Non-verbal capacities of reasoning lower than the normal measured by the non-verbal scale of Wechsler (for controls only)
• Presence of pervasive developmental disorders
• No affiliation to a social security regimen
• Absence of signature of the informed consent
• Subject of less than 8 years

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Control adults; lexical tests and electroencephalogram (EEG).	Behavioral: auditory lexical decision task; Device: electroencephalogram
Dyslexic patients; lexical tests	Behavioral: auditory lexical decision task; Device: electroencephalogram
Dysphasic patients; lexical tests	Behavioral: auditory lexical decision task; Device: electroencephalogram

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Score Alouette reading test	In this test, the participant has to read in a loud voice a text, during three minutes. The final score takes into account the speed and the number of errors. For test performance, clinical groups will be compared with its controls.	at inclusion
Score EVALEC reading test	For test performance, clinical groups will be compared with its controls.	at inclusion
Score silence reading test	A group of letters will be presented and the participant has to say if this letters compose a known word. For test performance, clinical groups will be compared with its controls.	at inclusion
Score of reading comprehension test	For test performance, clinical groups will be compared with its controls.	at inclusion
Score of Khomsi	The objective of this group of different tests is to evaluate comprehension and production of oral language. For test performance, clinical groups will be compared with its controls.	at inclusion

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Measure of the electroencephalography power spectra	For test performance, clinical groups will be compared with its controls.	at inclusion
Correlation between electroencephalography power spectra and clinical outcome	For test performance, clinical groups will be compared with its controls.	at inclusion

Collaborators and Investigators

• Sponsor: Lille Catholic University
• Collaborators: Université Catholique de Louvain; Université de Lille 3
• Investigators: Study Director: Séverine Casalis, Université de Lille 3; Principal Investigator: Françoise Boidein, MD, Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL)

Study record dates

Study Major Dates

• Study Start: March 1, 2012
• Primary Completion (ACTUAL): March 1, 2015
• Study Completion (ACTUAL): June 1, 2016

Study Registration Dates

• First Submitted: August 16, 2016
• First Submitted That Met QC Criteria: August 16, 2016
• First Posted (ESTIMATE): August 19, 2016

Study Record Updates

• Last Update Posted (ESTIMATE): August 19, 2016
• Last Update Submitted That Met QC Criteria: August 16, 2016
• Last Verified: August 1, 2016

More Information

Terms related to this study

• Keywords: language disorders; developmental disorders of oral and written language
• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Neurodevelopmental Disorders; Language Disorders; Communication Disorders; Learning Disabilities; Speech Disorders; Dyslexia; Aphasia
• Other Study ID Numbers: RC-P0020

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO