Hunger, Satiety, and Metabolic Responses to High-fat Meals of Varying Fatty Acid Composition

This study evaluates the effects of dietary fatty acid composition from high fat meals on markers of hunger, satiety and metabolism.

Study Overview

• Status: Unknown
• Conditions: Body Weight Changes
• Intervention / Treatment: Other: MUFA-rich HF Meal; Other: PUFA-rich HF Meal; Other: SFA-rich HF Meal

• Study Type: Interventional
• Enrollment (Anticipated): 16
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Jada L Stevenson, PhD; Phone Number: 817-257-6310; Email: jada.stevenson@tcu.edu

Study Locations

• United States
  • Texas
    • Fort Worth, Texas, United States, 76102
      • Recruiting
      • Texas Christian University
      • Contact: Jada L Stevenson, PhD; Phone Number: 817-257-6310; Email: jada.stevenson@tcu.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• BMI of >18.5-24.9kg/m2
• Woman
• 18-40yrs of age

Exclusion Criteria:

• Evidence of weight loss or gain exceeding 5% of their body weight within the past 3 months.
• Plans to lose weight or begin a weight loss program between initiation of study and final testing.
• Plans to begin an exercise program or change current exercise routines between initiation of study and final testing.
• Is on a medically prescribed diet
• Does not consume breakfast regularly
• Rate less than 80% of foods offered in the buffet at 50mm or more on the 100mm VAS as palatable
• Medications that could influence appetite or sensory function
• Reports of metabolic or endocrine disease, gastrointestinal disorders, or history of medical or surgical events that could affect fat digestion and hormone signaling.
• Any chronic disease including type II diabetes, hypothyroidism, hyperthyroidism, cardiovascular disease, and cancer
• Any supplements that a subject begins taking between initiation of study and final testing.
• Anyone who is currently pregnant, lactating, or planning on becoming pregnant before the conclusion of this study.
• Anyone who has allergies to any of the components of the liquid meals
• Anyone who has donated blood in the last 20 days

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: MUFA-rich HF Meal; High-fat meal rich in monounsaturated fatty acids	Other: MUFA-rich HF Meal
Experimental: PUFA-rich HF Meal; High-fat meal rich in polyunsaturated fatty acids	Other: PUFA-rich HF Meal
Experimental: SFA-rich HF Meal; High-fat meal rich in saturated fatty acids	Other: SFA-rich HF Meal

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Peptide-YY	18 months

Secondary Outcome Measures

Outcome Measure	Time Frame
Visual Analog Scale	18 months

Collaborators and Investigators

• Sponsor: Texas Christian University
• Investigators: Principal Investigator: Jada L Stevenson, PhD, Texas Christian University

Study record dates

Study Major Dates

• Study Start: October 1, 2016
• Primary Completion (Anticipated): July 1, 2018
• Study Completion (Anticipated): July 1, 2018

Study Registration Dates

• First Submitted: November 8, 2016
• First Submitted That Met QC Criteria: November 15, 2016
• First Posted (Estimate): November 17, 2016

Study Record Updates

• Last Update Posted (Actual): July 26, 2018
• Last Update Submitted That Met QC Criteria: July 24, 2018
• Last Verified: July 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Body Weight; Body Weight Changes
• Other Study ID Numbers: CT2016JS1

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO