- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03011086
Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis
Evaluation of Auto Antibodies in Oral Sub Mucous Fibrosis - a Clinico-pathological Study
The etiology of OSMF is considered to be multifactorial. However, Role of autoimmunity had been suggested as one of the factors but remains unproven.
The present study is undertaken to evaluate the presence of auto antibodies in OSMF patients to pave a way for new arena of treatment with the etiology of this persistent condition
Study Overview
Status
Conditions
Detailed Description
Oral submucous fibrosis (OSMF) is a potentially malignant disorder affecting any part of the oral cavity, sometimes pharynx associated with juxta epithelial fibrosis causing progressive trismus leading to dysphagia. It is mainly seen in the Asian countries with more prevalence in India.
Etiology of OSMF is considered to be multifactorial. However, it is strongly associated with the use of arecanut in various forms and also in combination with other compounding factors. Autoimmunity had been suggested as one of the factors yet unproven.
Few studies reveal that there is high incidence of Autoantibodies including antinuclear (ANA), Anti smooth muscle (SMA), Anti thyroid microsomal (TMA), and anti reticulin antibodies in OSMF patients. These findings have not been consistent in further studies which needs further more research in this.
A study concentrated on quantitation of circulating immune complexes (CIC) levels which was established in patients with oral cancer and oral precancerous lesions. The levels were compared with that in normal controls and chronic chewers of betel quid with no signs of any disease. Both patients with oral cancer and oral precancerous lesions had elevated CIC when compared to both the control groups. The most interesting observations were (a) the CIC levels in the chewing controls were significantly raised when compared to normal controls; and (b) the CIC levels in the patients with premalignant lesions were elevated almost to the same levels as in the oral cancer patients.
HLA-typing was carried on areca nut chewers. however, it was unable to demonstrate a specific pattern of HLA-antigen frequencies in chewers with or without the disease. It is not necessarily a HLA-associated susceptibility in Oral Submucous Fibrosis.
Due to less number of articles published on autoantibodies, this study is done to evaluate the presence of such auto antibodies in OSMF patients thereby paving way for new arena of treatment on par with the etiology of this persistent condition.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Telangana
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Hyderabad, Telangana, India, 500060
- Panineeya Institute of Dental Sciences
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients who are willing for the study.
- A positive history of chewing arecanut, and/or smoking tobacco and alcohol.
- Patients with clinical and histopathological features of oral submucous fibrosis.
- Patients with OSMF not under any treatment for the same
Exclusion Criteria:
- Unwilling patients who do not want to be part of the study.
- Patients with known autoimmune disorders.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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oral sub mucous fibrosis
patients suffering with oral sub mucous fibrosis due to gutka/pan chewing confirmed by clinical examination
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control group
patients having gutka/ pan chewing habit without oral sub mucous fibrosis in oral cavity
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Evaluation of auto antibodies in oral sub mucous fibrosis
Time Frame: one and half year
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The subjects in the study suffering from oral submucous fibrosis will be clinically evaluated and graded based on criteria given by Khanna et al classification.
All the subjects included in the study will also be subjected to serum analysis for presence of auto antibodies in their serum by Titerplane technique.
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one and half year
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Collaborators and Investigators
Investigators
- Principal Investigator: NALLAN CHAITANYA, MDS, Associate Professor
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PMVIDS/OMR/0016/2014
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Oral Submucous Fibrosis
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The Oxford Dental College, Hospital and Research...CompletedOral SubMucous Fibrosis
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Altamash Institute of Dental MedicineCompletedTumor | Pentoxifylline | Triamcinolone | Vitamin E | Oral Submucosa FibrosisPakistan
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Ziauddin UniversityNot yet recruitingOral Submucous FibrosisPakistan
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H.K.E.S's S.Nijalingappa Institute of Dental Science...Unknown
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Ziauddin UniversityCompletedOral Submucous FibrosisPakistan
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The Oxford Dental College, Hospital and Research...Credora Life Sciences, IndiaCompletedOral Submucous Fibrosis
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Government College of Dentistry, IndoreCompletedOral Submucous Fibrosis
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SVS Institute of Dental SciencesUnknownOral Submucous FibrosisIndia
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Sir Ganga Ram HospitalRecruiting
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The University of Hong KongNot yet recruitingOral Cancer | Oral Leukoplakia | Erosive Lichen Planus | Oral Submucous Fibrosis | Proliferative Verrucous Leukoplakia | Oral Erythroplakia